Sam Jeans

Four brain health IPT projects. All funded by the community. All targeting different mechanisms behind neurodegeneration. Here's where each one stands today. ⬇️

We are live on our Q1 2026 Townhall - a lot of updates, outlook, and more. Join us now! Feel free to share your questions as well and we will answer them all.

Thank you for attending our Q1 2026 Townhall. You can watch the recording if you missed it. Here is what we announced: 💊 Congition is live! Brain Health Supplements. 📱 Cortex App is live! Brain Health Index with NEURON Rewards. Visit: cerebrumdao.com

We're getting ready for the next Townhall. Cortex. Cognition. CerebrAI. IPTs. Exciting results in the pipeline. There's a lot to unpack. Join us by RSVP'ing below. 👇 luma.com/wr0xdcjs

Cognition is live! 🚀 We have been building this for some time – a dedicated platform for brain health products selected by the Cerebrum DAO community. Percepta is there, as many of you expected. But we also have a few additions we think you will like. cognition.cerebrumdao.com

We are very excited to say Phase 0 of our Cortex app is imminent! ⚡ Current sign-ups will be sent instructions in the next few days. You can join the 1,000+ who have already signed up for early access here: cerebrumdao.com/cortex-app Stay tuned for more release information.

We got to a place with heart health where you can measure it, understand risk, and intervene. That took decades of research and commitment. Brain health is more complex. We're still early. But we will get there. That's what we're here for. The next frontier in human health.

Cortex is coming. Your brain changes every day, but most people have no way to track it. Let's change that.

Current anti-inflammatory drugs suppress the immune system. That's a problem when you're treating diseases that take years to progress – you can't keep someone immunosuppressed indefinitely. Our compounds can work differently by blocking the link between chronic inflammation and mitochondrial dysfunction. Currently investigating 15 new drug candidates as we head towards new milestones this year.

The @Neuron_Percepta trial is fully decentralized. How it works: → Participants recruited remotely, products shipped directly to them → Wearable sensors track sleep, HRV, and activity continuously → At-home blood collection for P-tau 217 biomarker tracking → Cognitive assessments administered through dedicated trial software The result is a depth of data that conventional trial structures simply can't match, paired with the ability to reach participants wherever they are. View the project and track the results @molecule_DeSci: discovery.molecule.xyz/labs/cerebrum

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‼️The Cognition Store launches imminently. Brain health science backed by community capital, validated through research, available to all.

Inside our @Neuron_Percepta trial. We're tracking p-Tau 217 through at-home blood collection, running neurocognitive assessments, and integrating wearable monitoring for sleep, HRV, and activity. All within a 6-month, double-blind, decentralized, randomized placebo-controlled design with IRB approval secured

@bryan_johnson RHR/HRV really isn't that useful in isolation for everybody. After a week of cycling every day, my HRV approaches 40 with a HRV of 150+. But I still generally sleep terribly, as per my data. Low HR can be a localised response due to metabolic depression in some.

My heart rate before bed last night: 38 bpm In the 99.9th percentile. The 40 hour social media fast dropped it by around 10%. Seems social media could be a 10% tax on my nervous system. RHR is the most important marker I track. It's a tell-all of health and habits. This single number reveals stress, food, screens, fitness, relationships and more. Show me your RHR and I'll see your soul. Lowing your RHR before bed is the #1 thing you can do to improve your health. A low RHR will boost sleep quality. High quality sleep: > Mental acuity up 15% > Insulin sensitivity + glucose control better by 25% > Self control up by 20% > Mood enhanced by 15–30% > Physical performance improvement by 10% > Lower injury risk by 20–60% My suggestions for you: + final meal four hours before bed + screens off one hour before bed + read a book 10 min before bed + in bed at the same time every single night Master these and then you can add on more layers to get even better.

We set out to find compounds that improve protein printing accuracy. We found something we didn't expect. Our initial two compounds don't act directly on the translation machinery. They improve protein fidelity through an indirect pathway, meaning there are new interactions we haven't fully mapped that control how accurately your cells build proteins. This enriches the potential of the Transfidelity project.

DeSci is still out there delivering outcomes. Important category of Web3 where outcomes are anchored to real milestones.

The news is out. This will be a 6-month double-blind, decentralized, randomized control trial funded by token-holders. A powerful moment in DeSci's potential to pursue clinical research with support from the community. Find the token here: molecule.xyz/ipts/claw

Your cells build proteins using machines called ribosomes. They're accurate – but not perfect. About one in every 10,000 amino acids exhibits errors. With age, those systems weaken while the error rate rises. Misfolded proteins accumulate. This is translation fidelity – the accuracy with which your cells produce proteins. It declines as you age.

‼️ Major announcement: Our Percepta human trial has received IRB approval. This will be a 6-month, double-blinded, decentralized, randomized controlled trial crowded-funded by IP tokens – a world’s first and huge milestone. We are very grateful to everyone who has supported the project. Updates via @Neuron_Percepta