Saurav Kumar

38 posts

Saurav Kumar

Saurav Kumar

@Saurav054

Post-Doc 🔬@FredHutch..Chemical Cancer biology..Cell migration.. Cancer Biology. Alum: @iiscbangalore

Seattle, WA Katılım Temmuz 2020
614 Takip Edilen217 Takipçiler
Saurav Kumar retweetledi
Fred Hutch Cancer Center
Fred Hutch Cancer Center@fredhutch·
In a study published today in @jclinicalinvest, @behnamnabet and collaborators describe how they used targeted protein degradation in mice to rapidly destroy lung and pancreas tumors caused by a variant of a commonly mutated, cancer-driving gene. bit.ly/42di54B
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Saurav Kumar
Saurav Kumar@Saurav054·
Excited to share our amazing work demonstrating that the degradation of KRAS G12V by dTAG induces antitumor immunity in a transgenic mouse model for lung cancer! jci.org/articles/view/…
Behnam Nabet@behnamnabet

Ready, set, degrade! So proud to share our work in @jclinicalinvest, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer. Link: jci.org/articles/view/… 🧵

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Abhishek Kumar
Abhishek Kumar@Abhishek_Mito·
@Saurav054 Exciting work. Congratulations Saurav and all the authors!🎊🎉
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Saurav Kumar retweetledi
nature
nature@Nature·
Nature research paper: Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF go.nature.com/4aA7Rfz
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Saurav Kumar retweetledi
Shinya Tsukiji Lab
Shinya Tsukiji Lab@TsukijiLab·
Excellent review by @Saurav054 and @behnamnabet highlighting recent innovative approaches for chemically controlled protein relocalization. Thanks for also mentioning our self-localizing ligand approach!
Behnam Nabet@behnamnabet

Are you interested in strategies to control the spatial localization of your favorite protein at will? In our review, @Saurav054 and I discuss the exciting development of chemical inducers of proximity to control subcellular protein localization. authors.elsevier.com/a/1ikNC3S7Zk9Z…

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Saurav Kumar retweetledi
Behnam Nabet
Behnam Nabet@behnamnabet·
Are you interested in strategies to control the spatial localization of your favorite protein at will? In our review, @Saurav054 and I discuss the exciting development of chemical inducers of proximity to control subcellular protein localization. authors.elsevier.com/a/1ikNC3S7Zk9Z…
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Saurav Kumar retweetledi
Behnam Nabet
Behnam Nabet@behnamnabet·
It was a pleasure to highlight the recent innovative studies from the labs of @SchreiberStuart and Matthew Meyerson (NICE approach), @StevenMBanik (TRAM approach), and @DanNomura (covalent recruiters of 14-3-3 proteins).
Behnam Nabet tweet media
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Saurav Kumar retweetledi
Alice Berger
Alice Berger@aliceb_phd·
The Berger lab is hiring! We have openings for post-docs and research techs right now! Feel free to apply or just reach out to chat. Our lab uses functional genomics to map cancer genotype to phenotype at scale. Come join us! Links in thread
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Saurav Kumar retweetledi
Biofactoid
Biofactoid@biofactoid·
Cas activates Inactive integrin. Inactive integrin activates Active Integrin. Cas activates Crk via binding. Crk activates Rac1 via binding. Rac1 acti... biofactoid.org/document/ac279…
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Saurav Kumar
Saurav Kumar@Saurav054·
My post-doc work is now online in #eLife. In this work, we show a two-step model for the initiation of integrin activation that starts with Cas clustering and phosphorylation. doi.org/10.7554/eLife.… @eLife
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Keşfet

@behnamnabet @UPMC @jclinicalinvest @fredhutch @kdlahry @Abhishek_Mito @RamrayB @GenesisDbg