ScienceStanley

🎙️ "Me and my wife lost our three youngest kids to undiagnosed disease...and we wanted to make sure as much as we can, that other families, other kids don't end up in the same situation" Hear the story behind the founding of the @WilhelmFound from co-founder Mikk Cederroth

@gajesh Am doing some stuff mobilizing apple silicon to support research into rare genetic disease w/ some great groups like @WilhelmFound ... any chance you'd ever be down to have a chat? 🍎

Wake the world's sleeping compute. Look at the Mac nearest to you. What's it doing? Probably nothing. There are 100M+ Macs with Apple Silicon out there. Apple quietly made them *really* good at inference. A $3k Mac runs a 60B model at 30 watts. Most sit idle most of the day. Meanwhile every AI API call passes through three layers of margin before reaching the hardware. We call this the Inference Tax. We got curious: what happens if you connect idle Macs directly to inference demand? This is Darkbloom. Private inference network for idle Macs. darkbloom [dot] dev -- paper + code open. Reply for invite + free credits ↓

@manumish @biohub @finkd Would love to have a chat. 💜 Lead AI for a CZI family project: wilhelmfoundation.org Very excited about using ESM models to accelerate de-novo protein design for rare/poly-chronic conditions. 🧬

We're training AI to cure every disease. I lead AI Infrastructure at @biohub — Priscilla Chan & Mark Zuckerberg (@finkd) 's frontier AI Science lab, running one of the largest AI GPU clusters in science. We're hiring. Engineering + technical leadership. If you love AI, GPUs, and hard problems that actually matter — this is your moment. I'm the hiring manager. DMs open. JDs 👇 linkedin.com/posts/manumi_h…

@GabriCorso @boltz_bio Ohhhhhhhh Boltz team in Cali is beautiful! Lemme know if we could ever get you out to speak/jam at UCLA... ...so exciting, this weekend we'll actually be using Boltz to live design an auto-immune binder at the SAIRS conference: bruinai.org/sairs/

Over the next week, I’ll be in the US presenting some of the exciting work the Boltz team has been doing, with stops in Boston, San Diego, and New York! 🧬

DeSci is too niche. Between the Sapien Fund, global collaborations at the @Sei_FND and work across areas like longevity, DePIN, and sovereign nations, the category has evolved beyond pure 'DeSci'. We're expanding into something bigger: "Science & Innovation." I’ll be leading the way and I can’t wait to see what emerges in 2026. More in my latest 👉 seifdn.org/blog/innovatio…

@AdamDraper Kinda quaint to remember 'the tech doesn't work' being anything people cared about at scale. 😅

I’m old enough to remember Clinkle raising $25m as a Seed Round and the Venture world freaking out. 2025 is making Clinkle look like small peanuts. 🥜 So many Clinkles out there right now.

@AdamDraper 🤯

Sci-Fi

Wonderful paper from a wonderful team of scientists! Congrats @quantumgeometer, Luke and Daniel!

@AdamDraper We will be telling our grandkids what cancer was. 💜

Just committed an investment to another cancer cure. It's about time we solved that problem I think.

@dr_alphalyrae This roooooooooocks!

Odyssey, a family of multimodal protein language models for sequence and structure generation, protein editing and design biorxiv.org/content/10.110…

@gwei_sha Such a badass. Always grateful I'll be able to say I knew DeSci Legend Eleanor Davies when she was just getting off the blocks. 😜

first triathlon, first place. world championship next. solid

Waaaa phages are responsible for telomerases too? What can’t they do?

New systems-immunology methods are quantifying immune “health” across populations. By tracking patient data, @TsangLab and collaborators are revealing how the immune system adapts and signals disease. Read more in @techreview. bit.ly/46MGShO

@eperlste aka this is about the worst take in the universe... and setting a note to return to this tweet in 2 years when rare disease omic data has been used to cure cancer and extend human life span.

@eperlste The aggregate dataset of rare-disease omics is probably the most valuable thing on planet earth.

“Rare disease cures are good for patients, but not for anyone else” This has to be one of the worst takes I’ve ever seen from TradBio. Why? Two main reasons TradBio gets ultra-rare completely wrong: 1) The value of ultra-rare cures is not commercial sales of single drug product per se, but the regulatory, clinical trial ops and manufacturing learnings that generalize across diseases and will allow US biopharma to complete with Chinese 996. The first individualized medicine milasen opened up a path for countless others. 2) A ultra-rare drug company with an approved product would be a profitable mega-efficient “baby biotech” yet TradBio doesn’t give a shit about a $10M a year drug. But a portfolio of profitable baby biotechs would be a money printer in the long run.

@QuantumBioDAO @QuantumBioOrg Happy birthday to one of the coolest dudes, and most knowledgable protein wizards! <3 A particularly crazy year to have been a human on the planet earth, but this crazy ride made much better by sharing it with you my friend. <3 Thanks so much for existing!

Happy birthday to Brian, one of the brilliant scientists at @QuantumBioOrg advancing the frontier of quantum biology. We’re lucky to have you in the ecosystem! Here’s to another year of pushing science forward. 🎉

@AdamDraper @takeonGravity Not sure if more impressed with the suit or the stache. 🫡

This was a life achievement for me this week. 📕32 years ago I read my first Iron Man Comic 🎬17 years ago I watched Iron Man 📜8 years ago we created the Iron Man investment thesis 💰7 years ago we invested in @takeonGravity 🚀Today I go to fly a jetpack Life is awesome.

Best few days ever. <3 Cannot thank the @WilhelmFound and enough for making something like this happen for Undiagnosed patients. youtube.com/watch?v=7LllEc…

@paulkhls @paulinapaiz02

I‘m hiring a Chief of Staff - the co-pilot in the DeSci starship // must be globally mobile, remote, cracked, in it for the science We‘re about to shift from Raptor 1 to 2 👨‍🚀 Email paul@bio.xyz with full application or referral intro - 100,000 BIO for successful referrals

@THalamandaris @QuantumBioDAO @jamessinka @BioProtocol @QuantumBioOrg @ClariceDAiello @LodesaniA @keerkat_ I tried to pull him over for a campus visit, but schedule was tight. Next time would be so fun to all hang at the UCLA Venture Bat Cave.

@ScienceStanley @QuantumBioDAO @jamessinka @BioProtocol @QuantumBioOrg @ClariceDAiello @LodesaniA @keerkat_ Very cool and fun to see James there too. Thanks for sharing.

@jamessinka from @BioProtocol dropped by the @QuantumBioOrg LA lab today. Got the grand tour, hung out in the lab, and checked out the latest instruments being built. DeSci is in motion! 🚀 @ClariceDAiello @LodesaniA @ScienceStanley @keerkat_