Seegar Lab

Structural basis for ADAM17 activation by the iRhom1 pseudoprotease: Cell Reports cell.com/cell-reports/f…

Congratulations to all involved! Structural insights into the activation and inhibition of the ADAM17–iRhom2 complex | PNAS pnas.org/doi/10.1073/pn…

Congratulations to folks that made this work come together. biorxiv.org/content/10.110…

@WRgordonlab @BlacklowLab Well deserved- congratulations

@BlacklowLab Congrats Steve!!!!!

Congrats, Steve!

Online now! Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors by Andrew N. Dates, Stephen C. Blacklow, and colleagues at @harvardmed @HMS_BCMP @DanaFarber dlvr.it/T5NScW #chembiol

Calling incoming PhDs! We're searching for a postdoctoral fellow passionate about uncovering mechanistic mysteries related to human disease at the molecular level. #ResearchOpportunity #ScienceJobs Apply now: jobs.uc.edu/job/Cincinnati…

🔬 Join our growing lab! We're searching for a postdoctoral fellow passionate about uncovering mechanistic mysteries related to human disease at the molecular level. #ResearchOpportunity #ScienceJobs Apply now: nature.com/naturecareers/…

Please RT (or RX?). My lab is looking for a postdoctoral fellow with expertise in cryo-EM to solve the structure of the RAC activator VAV3 in complex with binding proteins. Please email me if interested.

Congrats to Alex on his Notch paper published in Science Signaling! Special thanks to our fantastic team - Emily, Lena, Drew, Julia and collaborators. Click here to read the paper. science.org/doi/10.1126/sc…

Congrats to Colin with a special thanks to Emily and Khal!

Randy J. Read et al.: AlphaFold and the future of structural biology @Cambridge_Uni @AucklandUni @uwanews @UniofOxford @ActaCrystD @IUCr #AlphaFold #ProteinStructurePrediction #Crystallography doi.org/10.1107/S20597…

Congratulations to @HMS_BCMP faculty member Karen Adelmen for her election to the American Academy of Arts and Sciences!  @AdelmanLab @harvardmed

Our paper is out @ScienceAdvances! Check out how a single line of inner hair cells within the mammalian cochlea🐚 forms. Congrats to the fantastic @roecon91 @ShaharTaiber & Olga Loza. See the thread below. science.org/doi/10.1126/sc…

We have a Research Assistant position open in the Thompson Lab! We are looking for hard working individuals who are not afraid to learn new and diverse research techniques. Please see application links below. Fellow scientists please RT to spread the word!

Thanks to the folks @uofcincy for hosting a fun visit. Great to talk RNA regulation with @SeegarLab @catmak23 @igal_ifergan @TheLuolab @vestkat @IkegamiLab and others in the @biologyUC and @CincyChildrens - infectious enthusiasm in the grad students and faculty!

AlphaFold predictions: great hypotheses but no match for experiment biorxiv.org/content/10.110…

Structural Basis for Selective Proteolysis of ADAM10 Substrates at Membrane-Proximal Sites biorxiv.org/cgi/content/sh…

Our department is hiring! We have a collegial and supportive environment for junior faculty here. Please feel free to DM me if you have any questions! Assistant/Associate Professor, Structural Biology & Cryo-EM, Department of Molecular Genetics jobs.uc.edu/s/TCtrz8

BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

Congratulations to the @KovallRhett Lab and first author, Dr. Ellie Gagliani for their recent publication on understanding the mechanisms that drive Notch target gene dysregulation. pubmed.ncbi.nlm.nih.gov/35951645/