Wendy Gordon lab UMN

A lifetime of PCSK9 inhibitor treatment in one infusion.

New research published in @NatureBiotech from PICI researcher K. Christopher Garcia from @StanfordMed and collaborators introduces a new way to better understand how T cells recognize disease. Using a combination of high-throughput screening and AI-based modeling, the team mapped how individual T cell receptors respond to millions of peptides. Their approach helped identify potential disease-linked autoantigens connected to ankylosing spondylitis and acute anterior uveitis and could help accelerate future discoveries in immunotherapy and precision medicine. Read the study: nature.com/articles/s4158…

@Gymnastics_Now So exciting!

Midwest Gymnastics announced Wednesday that Jeff Graba has been hired to coach the club's optional and elite athletes, joining his twin brother Jess Graba, who is the owner and elite head coach of Midwest and has coached Suni Lee to the past two Olympic Games. Jeff and Auburn parted ways in April after he coached the Tigers for 16 seasons. (📸 of Jess & Jeff via Midwest Gymnastics)

A dividing cell videoed through a microscope. Hot tip: Don't mess around with myosin II paralogs if you don't want your cells to freak out. #CellBiology cell.com/cell-reports/f…

Protein/enzyme engineering has a severe bottleneck — and it's not in AI modeling or compute time. It's in actually building and testing protein variants. Proud to introduce our latest work, MIDAS: a way to go from primers to protein assays in mammalian cells in one day. 🧵

Notch signaling tunes the environmental responsiveness of intestinal ILC2s @SciImmunology science.org/doi/10.1126/sc… @nkg2d1 @theonlylabever @UofT 🇨🇦

Stunning! A protein cocktail designed by AI drastically increases fibroblast to skeletal muscle transdifferentiation efficiency from ~2% to ~20%😆 biorxiv.org/content/10.648…

Increased mRNA-lipid nanoparticle transfection per ng mRNA by concentrating cells @ubcmsl #fig0005" target="_blank" rel="nofollow noopener">sciencedirect.com/science/articl…

A highly efficient nonviral knock-in platform for NK cells, enabling plasmid-based genome editing with up to ∼90% knock-in efficiency and ∼100% recovery rupress.org/jem/article-ab… @JExpMed #Felices #Miller @UMNews

Engineering B cells to express fully customizable antibodies with enhanced Fc functions @NatureComms @KECKSchool_USC nature.com/articles/s4146…

A small piece in @NatureRevGenet highlighting our INSTALL technology: Immune-evasive DNA + recombinases for non-viral gene insertion. 🧬 nature.com/articles/s4157…

The physical landscape of CAR-T synapse hubs.li/Q04f56xq0 Impactful biophysics research from @BiophysJ (@BiophysicalSoc) @YaleCellBio

Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource go.nature.com/3Z1q0PM rdcu.be/feuEP

Antigen-stabilizable fluorescent nanobodies that become fluorescent upon binding intracellular targets enable background-free multicolor imaging and biosensing in living systems. @EinsteinMed @salkinstitute @animmerj nature.com/articles/s4159…

the new david baker's paper is a very good read if you are designing binders

🚨Prime editing breakthrough (April 29, 2026) Researchers at UMass Chan Medical School have developed “Prime Assembly”: a method to insert large DNA fragments (up to 11 kb) with high precision and without double-strand breaks in the genome. They use two pegRNAs plus linear donor templates that assemble inside the cell. It works in quiescent cells and has already been demonstrated by inserting full genes such as dystrophin and CARs. Prime Assembly (PA) perfectly complements their platform and PASSIGE technology for large insertions, opening the door to more indications (DMD, allogeneic CAR-T, etc.) with lower risk. Another step that reinforces why prime editing remains the most versatile gene-editing technology. Source: nature.com/articles/s4158…

Excited to share our work on ErbB receptors published today @CellCellPress! Using multicolor, photostable UCNPs, we perform long-term (>15 min) single-particle tracking of EGFR, HER2, and HER3, enabling direct visualization of dimerization in live cells. cell.com/cell/fulltext/…

Structural basis for ADAM17 activation by the iRhom1 pseudoprotease: Cell Reports cell.com/cell-reports/f…

Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.

@cancer_curious @arjunrajlab Haha I did that this week too :)

So I bought from Addgene , what I once submitted to Addgene 😅