Sheldon L. Holder

@weldeiry This is an extraordinary accomplishemt!! Congratulations @weldeiry on your insight, vision, strong science, and persistence. The field, and the world, needs more people like you!

Pleased to see FDA accelerated approval for Dordaviprone (ONC201/TIC10) discovered in my lab 18 years ago & congratulations to all who contributed to basic science, translation, clinical testing & approval. onclive.com/view/fda-appro…

.#LegorretaCancerCenter @BrownMedicine grateful to @SheldonLHolder for impact in RI over yrs. He led Cancer Talk Cafe featuring discussions w/ community. Holder passed baton to @SheRiseRogersMD who will be leading Outreach as he moves to leadership in MI. linkedin.com/posts/wafike_l…

@weldeiry These findings may also indicate a difference in the drivers of disease in this population of patients.

PSMA-PET/CT identifies 'atypical' metastases in prostate cancer patients auntminnie.com/clinical-news/…

@tajiknia @weldeiry @BrownUCancer @TheNRMP Congratulations!

#Match2025 I am thrilled that I get to stay in #RhodeIsland for my training where my family and mentors are! Beyond grateful! @weldeiry Thank you for your support to all my mentors and my fiancé! @BrownUCancer @SheldonLHolder @TheNRMP

@CarikaElshae This is how breakthroughs are born!! Congratulations @CarikaElshae @CariGenetics

This is a dream come true 🥹🥹🥹 Ensuring the Caribbean is represented in global genomics is HERE. #Watchthisspace

Why does diversity in genetic research matter? Because it ensures equitable health outcomes for communities like ours in the Caribbean. Genetic research shapes everything from prevention to treatment, and we need to make sure no one is left behind. #HealthEquity #CaribbeanScience

A photograph of Malcolm X's mother, Louise Norton Little (1897-1989). Louise Little was a brilliant woman, speaking multiple languages, and for years, along with her husband Earl Little, a dedicated activist of Marcus Garvey's Pan-African Movement (Universal Negro Improvement Association and African Communities League). Louise Norton Little (1897-1989) was a Grenadian-born American activist and the mother of Malcolm X. Here are some key facts about her life. - Born in Grenada to a former slave from Nigeria and a Scotsman - Raised by her grandparents in Grenada - Immigrated to Canada in 1917 and joined the UNIA (Universal Negro Improvement Association) - Met her husband Earl Little at a UNIA meeting in Montreal and married in 1919 - Had eight children with Earl, including Malcolm X - Was a Garveyite activist who taught her children about black pride and self-reliance - Was committed to a mental institution for 24 years and released in 1963 with the help of her children - Lived with her family in Grand Rapids, Michigan, until her death in 1991 at the age of 94

4 years before Rosa Parks ignited the Montgomery Bus boycott by refusing to give up her seat in Alabama, there was PFC Sarah Keys from the Keyesville neighborhood of Washington, NC, who when traveling from Fort Dix in NJ back home to Washington, NC on August 1, 1951, was told to relinquish her seat to a white Marine and move to the back of the bus. Keys refused to move, thus the driver emptied the bus, directed the other passengers to another vehicle, and barred Keys from boarding it. When Keys asked why she shouldn’t ride the bus, she was arrested and spent 13 hours in a cell. Keys was eventually ordered to pay a $25 fine for disorderly conduct, was released, and put on a bus to her hometown. Her case was brought before the Interstate Commerce Commission with Dovey Johnson Roundtree as her lawyer and wasn’t settled until 1955. In Sarah Keys v. Carolina Coach Company, the ICC favored Keys, ruling the Interstate Commerce Act forbids segregation.

Great presentation by @BrownUPathoGP student Kimberly Meza @ksmeza about modulation of TRAIL death receptor DR5 in liver cancer through ASB3

Great presentation by @BrownUPathoGP PhD student Kim Meza @ksmeza, member of @SheldonLHolder lab #HolderLab at #LegorretaCancerCenter @BrownUCancer @BrownMedicine on collaborative studies with our #eldeirylab on targeting PIM1 kinase to sensitize RCC to TRAIL agonists. This could evolve as a future therapy for RCC.

@myheroistrane @CchristmColleen @belindafu @ralanshirley @SSawning @moniztracy1 @KRakszawski @BMcGillenMD @GIMaPreceptor @VipsMDMEd @EricLast3 @dhpomerantz @meggerber Lee Morgan. That's all you have to say.

#sundayjazz @CchristmColleen @SheldonLHolder @belindafu @ralanshirley @SSawning @moniztracy1 @KRakszawski @BMcGillenMD @GIMaPreceptor @VipsMDMEd @EricLast3 @dhpomerantz @meggerber #Jazz #Autumnvibes Follow #JazzForToday for daily moments of peace. m.youtube.com/watch?v=qJi03N…

Thankful to our #LegorretaCancerCenter administration and leaders for all the hard work of preparation and presentations to our EAB today. Also grateful for all the feedback we received from our advisors. Our work is intensifying as we strive for impact on our community and region. @BrownUCancer @BrownMedicine @BrownUniversity @ShiOnaCo @RoyJensenMD @DrPhilKantoff @weinerg @MarianaStern @Dr_R_Kurzrock @rwsobol @drdonsdizon @bcarneiro7 @LiangChengMD @SenduraiMani @CaraMath @Roxanne344 @insarkar @DrSGraff @SheldonLHolder @DawsonStemCell @slibutti @DrRobWinn @DrJoannSweasy @LeonidasPlatan1 @LauraStroudPhD

On this day in 1835, a mob of white citizens and a hundred yoke of oxen pulled a Black school to a swamp outside the town of Canaan, New Hampshire and fired cannons to the boarding homes of the black students. —On August 10, 1835, nearly 500 white men destroyed the Noyes Academy in Canaan, New Hampshire, using 100 oxen to pull the schoolhouse off its foundation and drag it a mile down the road. Noyes Academy was a new integrated school (the second in the country) founded by abolitionists with 28 white and 14 Black students. The African American students, who came from all over the Northeast, traveled long distances in the face of adversity to get to the school. Students included future leaders of note such as Henry Highland Garnet and Alexander Crummell. Noyes Academy was a new integrated school (the second in the country) founded by abolitionists. The African American students, who came from all over the Northeast, traveled long distances in the face of adversity to get to the school. Students included future leaders of note such as Henry Highland Garnet and Alexander Crummell. After destroying the school, the mob fired cannons into the homes where the African American students were boarding and threatened the students. Shots were exchanged which created a distraction for the Black students to escape out of town. Despite attempts to repair and reopen the school, the structure was burnt to the ground three years later.

Great strategic research planning session with scientific and clinical leaders at #LegorretaCancerCenter at @BrownUniversity @BrownMedicine @BrownUCancer @BrownUnivHealth @carenewengland @HasbroChildrens There is something magical and that is great to see when a senior leadership group works intensively together for many months to shape a future vision at a place like Brown University. It takes a special group to work cohesively together across disciplines with a common mission and vision. Honored to facilitate the pursuit of research excellence to serve our communities in Rhode Island and beyond. Research and innovation bring hope for better days with less burden from cancer here and elsewhere. @ShiOnaCo @rwsobol @bcarneiro7 @LiangChengMD @insarkar @SeanLawler20 @DawsonStemCell @drdonsdizon @CaraMath @SheldonLHolder @Roxanne344 @SenduraiMani @DrSGraff @LauraStroudPhD

@ksmeza Great job @ksmeza!! You have proved a great experience for these high school students.

Just completed teaching my Bench to Bedside; Translational Cancer Biology for Targeted Therapies course with 22 motivated high schoolers! These topics caught the eye of my 2024 cohort! They learn molecular biology approaches in lab and learn how to design a relevant hypothesis!

@weldeiry @Oncotarget @OncotargetJrnl Congratulations @weldeiry and @Oncotarget @OncotargetJrnl!!

I am pleased to join @Oncotarget @OncotargetJrnl as an Editor-in-Chief this June, 2024. This is a great journal that was started in 2010. The journal has published impactful research over the years by leaders in the field. The journal is indexed in PubMed, PMC, and MEDLINE and has its own digital archive. Oncotarget follows the guidelines based on the recommendations of the Committee on Publication Ethics (COPE). The journal conducts author interviews and promotes published research through press releases. oncotarget.com/archive/ oncotarget.com/article/101/pd… oncotarget.com/videos/intervi… oncotarget.com/news/pr/ I’d like to invite my colleagues to submit manuscripts and would particularly encourage translational research, progress in precision oncology, therapy for cancer’s hallmarks, drug resistance, plasticity, epigenetics, microbiome, environmental carcinogenesis, intersection of behavior and biology of cancer, cancer immunotherapy, functional precision medicine, molecular imaging, theranostics, stem cells, liquid biopsy and tumor heterogeneity. Problems such as CNS primary or metastatic cancers, blood brain barrier research, viruses and cancer, cell cycle and cell death, biomarkers (predictive, prognostic, and pharmacodynamic), pro-drugs, nanotherapeutics, drug metabolism, novel omics, tumor dormancy and early detection are of interest. Technology enabling of progress using AI, statistics and novel clinical trial designs, new devices for diagnostics and therapeutics, single cell profiling, 3-D visualization of TME, single molecule visualization. We welcome clinical case reports, case series, commentaries, reviews, clinical trial results, and Meeting Reports. Please feel free to reach out to me directly if you have any questions or manuscripts we might consider. I hope you will have a positive experience in sharing your contributions of new knowledge and/or expertise in an efficient manner with Oncotarget. I look forward to having positive impact in this new role working with Mikhail Blagosklonny, MD, PhD (Misha) @Blagosklonny and Andrei Gudkov, PhD at @RoswellPark I previously served as the founding Editor-in-Chief of Cancer Biology and Therapy for 18 years from 2001-2019. tandfonline.com/toc/kcbt20/1/1… x.com/weldeiry/statu… @BrownMedicine @BrownUniversity @BrownUCancer @WIN_Consortium #LegorretaCancerCenter #eldeirylab @AmericanCancer @ACSCANRI @OncoAlert @oncodaily @AACI_Cancer @theNCI

@KemiDoll Congratulations!! A well deserved promotion. Your representation and work is making a difference!

Great to have physician-scientist and thoracic medical oncologist Dr. Tao Zou @TaoZou2 visiting the #LegorretaCancerCenter @BrownUCancer from @DanaFarber @BrighamWomens to speak about innate immune sensing pathways as cancer therapeutic targets. @ShiOnaCo @bcarneiro7 @JerryAzzoli @HinaKhanMD @rwsobol @SenduraiMani @SheldonLHolder @DawsonStemCell @drdonsdizon @DrSGraff @BrownMedicine @BrownUniversity @LifespanHlthSys

BioQuest just completed the reference genome of the Grooved Brain Coral in Bermuda, marking a Caribbean first! 🧬🇧🇲 This groundbreaking achievement was made possible through collaboration with #CariGenetics #BioQuest #MarineConservation #BermudaScience

@trinalfletcher Congratulations!