Frank Paul Mora

@vineettiruvadi Gas has higher failure rate and higher maintenance. An electric generator is not technically challenging. It may take a while to charge.

What's better in an apocalypse?

The inside of a heart muscle cell photographed with an electron microscope. The powerhouses/overlords of the cell, mitochondria, are shown in pink. The repeating structures are the basic units of contraction that drive each heart beat (i.e., sarcomeres). #CellBiology

Circadian disruption (night shifts, LAN, social jetlag) ↑ breast cancer risk up to 78%. Chronotherapy (timing chemo/immuno to circadian phase) improves efficacy & reduces toxicity. Time matters in oncology. sciencedirect.com/science/articl…

Incredible …granzyme in from aged T cells causes age associated cognitive decline should we give #campath for aging ?? (bad joke) cell.com/immunity/fullt…

@vineettiruvadi Metabolites.

What type of dynamics research is not being properly/adequately supported by current funding mechanisms?

For #FluorescenceFriday, the work that motivated my move to Germany! I join the @erturklab to help develop novel approaches to neutralize and eliminate residual viral proteins commonly observed in #LongCovid patients, particularly in the brain. Keep an eye out for our work!🧠💪🔬

@erturklab You can learn more about the cutting-edge techniques we are using to address this and other questions relevant to human disease in the preprints below: biorxiv.org/content/10.648… biorxiv.org/content/10.110… biorxiv.org/content/10.648…

Metameric lighting (visually identical, different spectrum): blue-enriched = cooling effect (0.7°C higher tolerance), red-enriched = warming effect. Spectral tuning can shift comfort range ±0.5°C → 5-11% HVAC energy savings. Light as non-visual thermostat sciencedirect.com/science/articl…

@MarcoFoster_ Netanyahu disapproved because he wanted the U.S. to destroy Iran. But now we have a fool for a president.

President Obama on Iran: “We pulled it off without firing a missile. We got 97% of their enriched uranium out. There’s no dispute that it worked and we didn’t have to kill a whole bunch of people or shut down the Strait of Hormuz”

@_K_Stiles AI might be effective in cheating but it may also be a boon to learning in that it can provide outlines of works but also expand less understood sections.

“AI is making ‘A’ grades easier to come by, a new study shows — and making them less useful to employers trying to size up college graduates.”

@kadamssl Cognitive bias implies conditioned. Assumptions are not intentionally hurtful but do so anyway. Younger males are more adept at acting on assumptions.

“Healthcare professionals exhibit the same levels of implicit bias as the general population…Cognitive biases have been associated with 28% of diagnostic errors. The harms fall disproportionately along lines of race, gender & other marginalized identities.” Well worth a read 👇

Time-restricted feeding (TRF) quadruples cross-tissue coordination of mitochondrial gene rhythms in mice (22 tissues). Coq10b emerges as top marker. Nutrient timing synchronizes mitochondria across organs – not just what you eat, but when. sciencedirect.com/science/articl…

@kadamssl I think women are forced to have the highest character where character is doing the right thing with little thought of the personal cost.

@InTime_49 When I say I slept 3 hours a night for a long time…I am not exaggerating. She has my respect, too!

This 📸 was taken at her kindergarten graduation. I was a single mom in the thick of my uni undergrad. Now this teeny tiny is graduating at the top of her class and has her pick of some of the country’s best programs. Mom just submitted her PhD application 🎓 Never give up.

Beautiful work, amazing. @mattlark ovid.com/10.1126/scienc…

Adding an adaptive “braking” mechanism makes brain simulations more realistic and better able to capture how changes in excitability shape brain rhythms. doi.org/10.1371/journa… #neuroscience

@heniek_htw Blood quality, oxygenation and delivery depends on systemic vascular/endothelial homeostasis. Also systemic but somewhat heterogeneous are ECMs which along with vasculature support cells but ECMs undergo fibrotic stiffening with age.

Decoding Human Longevity: Genetic and Molecular Insights from Accelerated to Successful Ageing sciencedirect.com/science/articl…

@_K_Stiles It's possible now for AI to ask leading questions to determine student understanding. This would be part of the the educational ideal of individualized education. Learners would use AI to explicate more, areas of incomplete understanding and AI would never tire of repeating.

#AItutors “Even if we can assume that a kid actually wants to engage with the [EdTech] product, there’s no way that the technology can figure out what’s going on in the mind of a young kid who’s grappling with something and trying to make sense of a concept that is new to them. This is the whole skill and art of teaching. So, you know, it’s doomed to fail,” says founder of Cognitive Resonance @BenjaminJRiley. From the article by @HKorbey posted by @DavidPBLRoss 👇🏻

Hypertrophic cardiomyopathy (HCM) has long been framed as a “sarcomere disease” — MYH7, MYBPC3, TNNT2, TNNI3, and other rare pathogenic variants explaining a major fraction of familial cases. But this new medRxiv preprint argues that HCM is also a polygenic disease, especially in patients without identifiable sarcomere mutations. In a GWAS discovery cohort of 2,284 HCM cases and 4,525 controls, Lopes et al. identified three genome-wide significant loci: BAG3, FHOD3, and PPP1R3A, with PPP1R3A proposed as a novel HCM locus. They then meta-analysed their data with recent large HCM GWAS datasets, identifying 70 unique loci, including four additional novel loci: MYPN, YWHAE, NOS1AP, and OBSCN. The most clinically interesting part is the polygenic risk score (PRS). Using lead variants from the meta-analysis, the authors built an HCM PRS and tested it in 411,213 UK Biobank participants. The PRS was strongly associated with HCM diagnosis: HR 1.88 per SD increase, and HR 3.19 for the top 5% vs lower 95%. Even among people without diagnosed HCM, higher PRS correlated with subtle imaging traits: greater maximal LV wall thickness and higher LV ejection fraction. This suggests that common variants may shape the myocardial phenotype long before clinical disease is recognized. The key stratification: sarcomere-negative HCM. In 1,756 HCM cases with outcome data, sarcomere-negative patients in the top 20% of PRS had increased risk of sudden cardiac death or equivalent events: HR 2.72, 95% CI 1.03–7.17. This is important because sarcomere-negative HCM is often clinically frustrating: fewer clear Mendelian answers, more heterogeneous phenotype, and uncertain risk architecture. A PRS may help reclassify part of this “genotype-elusive” space as common-variant-driven myocardial disease. Biologically, the novel loci are plausible. MYPN and OBSCN encode sarcomere/Z-disc-associated proteins; NOS1AP links to electrophysiology/QT biology; YWHAE is connected to cardiac sodium-channel regulation. Caveats: this is a preprint, not peer-reviewed; cohorts were mainly European ancestry; and partial UK Biobank overlap may inflate PRS performance. Independent replication is essential. Still, the message is clear: HCM genetics is no longer simply “rare sarcomere variant: yes/no.” It is becoming a spectrum: monogenic, oligogenic, and polygenic myocardial hypertrophy. Reference: Hypertrophic cardiomyopathy: a genome wide association meta-analysis and polygenic risk score. medRxiv. DOI: 10.64898/2026.05.05.26352435.

Aged circulating cytotoxic T cells are drivers of age-related cognitive decline. Removal of aged T cells, or their secreted factor granzyme K, rescues cognition in mice @ImmunityCP @VilledaLab @UCSF cell.com/immunity/fullt…