Stephen Banse

The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background 👉"Our results demonstrate the importance of assessing health and lifespan across genetic backgrounds in the effort to identify reproducible anti-aging interventions, with data underscoring how personalized treatments might be required to optimize health benefits." @StephenBanse, @granex | @AgingJrnl aging-us.com/article/205743…

@alperakay_ Ummm... isn't this just like the system that @TroyMcDiarmid et al published (PMID: 30361258)? And wasn't that work presented at the 2017 worm meeting, well before they submitted a provisional patent?

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So much damage is being done by archaic restrictions on the number of citations allowed in papers. Come on, it's all online anyway, lets find ways to solve this (people get offended, and important references are lost for no reason)

I’m happy to share TARDIS! High-throughput, library transgenesis for multicellular systems! Where we make C.elegans (genetically) bigger on the inside! (biorxiv.org/content/10.110…). 🧵

Latest from the CITP (and our lab) in @AgingCell: Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes onlinelibrary.wiley.com/doi/10.1111/ac…

we're recruiting for postdocs! see ad here: kr-colab.github.io/recruiting

New preprint: Sexually Antagonistic Selection on Genetic Variation is Rare in Humans. Giant analysis led by @katjakasimatis in collaboration with Abin Abraham in Tony Capra’s lab. With @pastramimachine and @petrelharp. biorxiv.org/content/10.110…

Caenorhabditis Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes micropublication.org/journals/biolo…

Preprint long time coming: Full chromosome-level genome assembly for the highly polymorphic nematode Caenorhabditis remanei. Our third—and hopefully final—version for this species. Lots of structural comparison with C. elegans too. Amazing work by @attrna. biorxiv.org/content/10.110…

Latest pub from the Caenorhabditis Intervention Testing Program (CITP) aka Driscoll/Lithgow/Phillips labs: Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions @StephenBanse link.springer.com/article/10.100…

Check out our new manuscript if you are interested in the genomic organization of repetitive elements! with @attrna "Degradation of the repetitive genomic landscape in a close relative of C. elegans" biorxiv.org/content/10.110…

Our latest preprint: An open source microfluidic sorter for Caenorhabditis nematodes. biorxiv.org/content/10.110… See @benblueAK super amazing 3D Game of Thrones style device animation here: youtube.com/watch?v=O-ZICJ…

Automated Lifespan Determination Across Caenorhabditis Strains and Species Reveals Assay-Specific Effects of Chemical Interventions biorxiv.org/cgi/content/sh… #bioRxiv

Please check this out and share with good candidates. I've got to say, it is a very exciting time to be in our lab. We basically feel that we can do almost anything in terms of genetics, genomics, and technology. Lots of important scientific questions to focus on.

New finding from Coleman-Hulbert et al.: Caenorhabditis Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes #micropublish #celegans #aging micropublication.org/journals/biolo…

Patterns of putative gene loss suggest rampant developmental system drift in nematodes dlvr.it/R47XwV

A terrific new theory preprint with @katjakasimatis and @petrelharp: Limits to Genomic Divergence Under Sexually Antagonistic Selection. Addresses a number of unacknowledged challenges using genomic differences b/w males and fems to infer sexual conflict. biorxiv.org/content/10.110…

Now out in print: A large close relative of C. elegans is slow-developing but not long-lived. Latest in the saga of the new fig-dwelling species, C. inopinata, led by @weird_worms. They live bigger and slower, but not longer. bmcevolbiol.biomedcentral.com/articles/10.11…

Now officially early online at G3: Environmental and evolutionary drivers of the modular gene regulatory network underlying phenotypic plasticity for stress resistance in the nematode Caenorhabditis remanei. g3journal.org/content/early/…

Our latest preprint. Led by graduate student Heather Archer.