pinotsislab

Our work was featured among the most popular stories Physics World published in 2025 physicsworld.com/a/winning-the-…

Thanks @StuartHameroff This is in my project wishlist. Just extend my models for electric fields generated from neurons to models for fields from microtubules, the math is similar, see e.g. link.aps.org/accepted/10.11…

@djeucharist @StuartHameroff The aggregate electric field generated by them that also feeds back to them sciencedirect.com/science/articl…

@StuartHameroff For the Orch OR Orchestra who is the conductor?

I disagree that action potentials are the fundamental mode in consciousness. They may just report conscious results from end-integration/orchestration, e.g. Orch OR among layer 5 pyramidal neuron soma with their huge arrays of mixed polarity microtubules. As the articles show, the brain uses photons and electromagnetic oscillations at multiple frequencies. How does the brain, and life in general transcend and integrate over spatiotemporal scale??? Microtubule time crystals engage in terahertz, gigahertz, megahertz, kilohertz and hertz (EEG). ingentaconnect.com/content/imp/jc… These oscillations can be entangled and coherent across brain regions and support consciousness in the Orch OR theory. Terahertz: photons in EEG (Murugan) and microtubules (Craddock, Tuszynski) Gigahertz and megahertz inter neuronal signaling journals.physiology.org/doi/full/10.11… Kilohertz (Neuralink) Hertz Isolated microtubules oscillate at 39 hertz pmc.ncbi.nlm.nih.gov/articles/PMC10…

In #depression, electric fields diverging from the activity of neurons that generate them may signal a loss of coordinated control—much like an orchestra in which musicians gradually drift out of alignment with the conductor academic.oup.com/cercor/article…

Action potentials are fundamental but there is more going on in brain function. doi.org/10.3389/fnsys.… #neuroscience

@kanair Is this a good ref? frontiersin.org/journals/psych…

@dimitrispp This might work as a method to identify an NTIC core in the brain.

Thinking about defining Koopman NTIC.

I still love studying consciousness, but I'm now more interested in abstract and mathematical ideas. It may be becoming a bit different from most research, and not many people like it. But sometimes I meet someone thinking similar things, and that makes me happy.

The dynamics of neurons, fields and their interactions shift in depression - w/ @HelenMayberg @crozSciTech @sankar_alagapan Tanya Nauvel Parisa Sarikhani academic.oup.com/cercor/article…

RT @BastosLabNeuro: Teaser for the MaDeLaNe summer school, June 1-3, 2026, at Vanderbilt: youtube.com/watch?v=vjxJ2W… Video credit: Alex Maier…

Phds&postdocs: join us for a summer school June 1-3 at Vanderbilt Univ. on Multi-Area, high-Density, Laminar Neurophysiology (MaDeLaNe). Get hands-on training from experts on advanced methods for analyzing neural data! No registration cost! Apply here: madelane.bastoslabvu.com

Work by Ghose and @dimitrispp on quantum effects in the brain is of the most-read physics stories of 2025! physicsworld.com/a/winning-the-… #neuroscience

Noise inside neurons may follow the same rules as quantum systems prognosis-innovation.com/quantum-brain-…

Changes in Intrinsic Activity of the Primary Somatosensory Cortex Causally Explain Differences in Emotion Perception in Autism @CityStGeorges @CityUniHealth onlinelibrary.wiley.com/doi/10.1002/au…

They also act at the molecular level to tune the brain. Work by @dimitrispp Pinotsis, D.A., Fridman, G., and Miller, E.K. (2023) Cytoelectric Coupling: Electric fields sculpt neural activity and “tune” the brain’s infrastructure. Progress in Neurobiology, doi.org/10.1016/j.pneu…

Here's a metaphor. Cognition is sand on a vibrating speaker. The sound waves of musical notes create patterns in the sand. In the cortex, brain waves are the vibrations, neurons are the sand, and your conscious thoughts are the patterns that emerge. #neuroscience

@SebastianSeung Consider this: Cortical neurons spike only intermittently. Around 15–20 Hz in short bursts. And astrocytes are roughly 30% of cells. They don’t spike, but they still propagate electrical influences. By contrast, electrical influences are present in every cell, all the time.

This result quietly shifts how we should think about neural variability. If ephaptic coupling matters, then variability isn’t just noise, it’s a signature of a shared extracellular field participating in computation. Small geometric differences (spacing, alignment, conductivity) can produce large functional effects via phase coupling. In that sense, “noise” may be the shadow of missing geometric degrees of freedom.

Right, cytoelectric coupling suggests that neural computation is guided by cytoskeleton fields that depend on the morphology of microtubules, proteins, filaments and other structures that determines the anisotropy etc you mentioned.

Really elegant work. What strikes me is that once ephaptic coupling matters, the extracellular space effectively becomes part of the system’s state. From that view, trial-to-trial variability looks less like noise and more like sensitivity to unmodeled field geometry (spacing, curvature, anisotropy). Do you see this implying that neural computation is underdetermined unless those geometric field constraints are made explicit?