pinotsislab

Right @StuartHameroff , microtubules could be the fastest to respond to field effects , e.g. once a memory is recalled, and balance out drift by being the first to reshape themselves so that they preserve the overall electric field after some neurons have dropped out.

Thanks Dimitris So the neural activity correlating with shifting mental representation comes from charge movements in cytoskeleton, like the charged C-termini tails with ions from each tubulin. ingentaconnect.com/content/imp/jc… And in your previous paper you showed that such activity sculpted information and memory into the cytoskeleton, e.g. in different neurons. In this paper @anirbanbandyo ‘s group showed functional communication among neurons mediated by cytoskeletal megahertz and gigahertz pubmed.ncbi.nlm.nih.gov/33881910/ So it’s possible representational drift is mediated through microtubules in different neurons (and glia?) oscillating and entangling in megahertz and gigahertz. Microtubules are the most likely site for memory encoding in the brain. pubmed.ncbi.nlm.nih.gov/22412364/ As Earl has been pointing out, it seems the brain has two modes. 1) A connectome-based computational modal mode, and 2) A distributed wave field-like, faster (?quantum) mode, possibly a collective time crystal. Maybe 2) is for consciousness, and 1) is for it to interface with the external world. And maybe we’re all like Steve Martin in his great film ‘The man with two brains’. @lndriscoll

@StuartHameroff Neural activity seems to be coordinated and constrained by the electric field arising from all charged structures in the cytoskeleton, including microtubules , and processes like mechanotransduction, resulting from cytoelectric coupling sciencedirect.com/science/articl…

@dimitrispp showed that electric fields carry info and have *little or no representational drift* Beyond dimension reduction: Stable electric fields emerge from and allow representational drift doi.org/10.1016/j.neur… #neuroscience

The geometry of neural dynamics along the cortical attractor landscape directly reflects changes in attention, as large-scale brain activity shifts across its hills and valleys depending on the state. nature.com/articles/s4146…

Congratulations Dimitris, Andre and Earl I think Predictive Coding/Recurrent Processing occurs at multiple scales including faster intracellular processing among mixed polarity networks of microtubules inside neuronal dendrites and soma (and ONLY there in all biology)! Here’s a paper we wrote in 1990 modeling information processing with error correction between two adjacent anti-parallel microtubules connected by microtubule-associated proteins (‘MAPs). ui.adsabs.harvard.edu/abs/1990PhyD..… They learned! Why else would dendrites and soma have networks of mixed polarity, interrupted microtubules in anti-parallel arrays? Is this how unicellular organisms use PC/RP? Is lower dimension actually slower frequency scales, e.g. through interference in faster microtubule oscillations?

@StuartHameroff What, in your opinion, are the best runners-up to Orch OR? (or best aspects of competing theories, etc) ... If you were to play devil's advocate and as a concession/further answer to critics.

New discovery! Spoiler alert: Neural dynamics are key. Evidence for predictive computations in a brain hierarchy during a visual search task doi.org/10.64898/2026.… Work led by @dimitrispp #neuroscience

Thanks @dimitrispp Will take a look. How does it jive with our microtubule time crystal? ingentaconnect.com/content/imp/jc…

Action potentials are fundamental but there is more going on in brain function. doi.org/10.3389/fnsys.… #neuroscience