Suessmuth Lab

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Suessmuth Lab

Suessmuth Lab

@Suessmuth_Lab

#naturalproducts #peptides #synthesis #biosynthesis Run by members of the Biological Chemistry Department of @TUBerlin.

TU Berlin, Germany Katılım Temmuz 2020
359 Takip Edilen1.2K Takipçiler
Suessmuth Lab
Suessmuth Lab@Suessmuth_Lab·
We're happy to announce our paper about the structural elucidation of the antifungal lipopeptide AFC-BC11 from Burkholderia cepacia complex incl. insights into central steps of its biosynthesis published in @J_A_C_S ! Congratulations, @leizhong94 🥳 pubs.acs.org/doi/full/10.10…
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Suessmuth Lab
Suessmuth Lab@Suessmuth_Lab·
Congratulations, Margareta and Maik!! Happy to see this one published🥳
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Suessmuth Lab
Suessmuth Lab@Suessmuth_Lab·
By the way, this animation is intriguing!!!
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Suessmuth Lab
Suessmuth Lab@Suessmuth_Lab·
Sooooo cooool to see this one submitted!! Paenilamicin's story does not seem to find an end yet! Thank you, @wilsonlab2 and the entire team for this achievement!! Fingers are crossed!!🤞
WilsonLab@WilsonLab2

Our preprint reporting the structure and mechanism of the natural product translation inhibitors paenilamicins is out…completely novel binding site on the ribosome! dlvr.it/T7CNnf…great collaboration with ⁦@Suessmuth_Lab⁩ ⁦@shuramankin

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Suessmuth Lab
Suessmuth Lab@Suessmuth_Lab·
@WilsonLab2 @shuramankin Please, you do not have to apologize... we are so blessed to have you and your team working alongside us. You have put so much work, time and effort into the elucidation of paenilamicin's MOA! Thank you again from our side! Better long than none🤣
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WilsonLab
WilsonLab@WilsonLab2·
Lastly an apology to @Suessmuth_Lab for taking so long to get the structure out but nailing the MOA required some additional work! The efficiency of the paenilamicins is influenced by the modification on position 37 of the A-site tRNA => context-specific inhibitor @shuramankin
WilsonLab@WilsonLab2

Special credit to first authors @TimmKoller and Max Berger. Also thanks to @shuramankin for hosting Max in Chicago to complete some experiments for this project and to Bertrand Beckert from @DCI_EM for great cryoEM data as always.

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Suessmuth Lab
Suessmuth Lab@Suessmuth_Lab·
Great news! Our publication "Gene amplifications cause high-level resistance against albicidin in gram-negative bacteria" has been highlighted as paper of the month! Congratulations to Mareike and @SimoneKosol and everyone involved🥳 dghm.org/aktuelles/pape…
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Suessmuth Lab retweetledi
Maik Damm 🐍
Maik Damm 🐍@DammMaik·
And now its official by all laws (damn we Germans love bureaucracy), that I am Dr. about Snake Venoms! Long way from my A level about snake venoms, via the master thesis about snake venoms to my PhD time in the @Suessmuth_Lab at the @TUBerlin about... snake venoms 🤘🐍
Maik Damm 🐍 tweet media
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Suessmuth Lab
Suessmuth Lab@Suessmuth_Lab·
So happy to see this one out! If you are interested in a resistance mechanism mediated by the GyrI-like transcription regulator towards the peptide antibiotic albicidin, please find the article here: plos.io/3YsQV5N Congratulations to @SimoneKosol and everyone involved!
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Suessmuth Lab
Suessmuth Lab@Suessmuth_Lab·
You've finally made it @DammMaik! Huge congratulations to your successful PhD defense! We wish you all the best in your scientific career and good luck with your future endeavours!
Suessmuth Lab tweet mediaSuessmuth Lab tweet media
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Ariane Nunes Alves
Ariane Nunes Alves@anunesalves·
My colleague @TUBerlin, Maria Andrea Mroginski, has an open PhD position in #compchem. The candidate will perform QM/MM calculations on metalloenzymes. Previous experience with MD simulations, QM calculations or python are a plus. Pls RT! jobs.tu-berlin.de/stellenausschr…
Ariane Nunes Alves tweet media
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