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We've recently launched a global survey on the potential use of #TILs for future trial designs and use in daily practice. We would love to hear what you have to say 👇fd7.formdesk.com/BQA/TILs_TNBC_…
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TILs Working Group
254 posts
TILs Working Group
@TILsWorkGroup
We are interested in the immune infiltrate in Breast cancer and what it means for treatment and prevention.
All over the world Katılım Aralık 2017
109 Takip Edilen833 Takipçiler
TILs Working Group retweetledi
Such a privilege to be part of the international TIL Working Group @TILsWorkGroup and to collaborate with Dr. Salgado on NeoTIL. #SABCS @muschollings @stolaney1 @OncBrothers @LoiSher
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TILs Working Group retweetledi
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TILs Working Group retweetledi
Amazing presentation by Roberto Salgado from @TILsWorkGroup
TIL assessment of APHINITY using CASE45 AI model and manual TILs (great ICC)
Combining AI and manual assessment is a better prognostic biomarker than either one of them
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TILs Working Group retweetledi
TILs matter in HER2+ BC!
In ShortHER trial, mapping their spatial organization with AI assessing:
🔹Immune-tumor interaction
🔹Aggregates/TLS (Hotspots)
further refines prognosis beyond manual evaluation
PS2-08-11 at #Sabcs25 @UniPadova @iov_irccs @TILsWorkGroup
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TILs Working Group retweetledi
Tagging @TILsWorkGroup to amplify this great work
Sherene Loi, MD@LoiSher
✨✨hot off the press from the #loilab. We show here that pregnancy & breastfeeding is associated with increased T cells in the normal breast and protection against #tnbc #breastcancer moving the role of immunity from treatment to prevention. 👏👏Thanks to @FAndreMD @DrChoueiri @MyriamChalabi for the opportunity to present #ESMO25 @OncoAlert @myESMO @PeterMacRes @PeterMacCC @UniMelb thanks to our funders @BCRFcure @TheMarkFdn @NBCFAus @Nature Article is here: nature.com/articles/s4158…
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TILs Working Group retweetledi
✨✨hot off the press from the #loilab. We show here that pregnancy & breastfeeding is associated with increased T cells in the normal breast and protection against #tnbc #breastcancer moving the role of immunity from treatment to prevention.
👏👏Thanks to @FAndreMD @DrChoueiri @MyriamChalabi for the opportunity to present #ESMO25 @OncoAlert @myESMO
@PeterMacRes @PeterMacCC @UniMelb
thanks to our funders @BCRFcure @TheMarkFdn @NBCFAus
@Nature Article is here: nature.com/articles/s4158…
Jose Fernando Moura, PhD@FernandoOnco
Translational data shows that #breastfeeding helps personal immunity improving CD8+ T This work can help to understand better the immune system and breastfeeding mechanisms @LoiSher @OncoAlert #ESMO25 @FernandoOnco
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The EU-funded MSCA Doctoral Network “Spatial Crosstalk in Immune-Oncology” (SpaXio) is now officially recruiting 14 PhD students to decipher the metastasis-promoting microenvironment of colon and breast cancer. More info here: tilsinbreastcancer.org/wp-content/upl…
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TILs Working Group retweetledi
😎if #TIL had been the prespecified biomarker, pembrolizumab might well be approved for this indication. PD-L1 IHC has real technical limitations- patients deserve multiple validated ways to identified immune enriched tumors. #TILs are simple, free & readily available- wait 🤔is that the problem? @oncoalert @TILsWorkGroup #bcsm
Medical.watch@MedicalwatchHQ
💫🌟Association of potential biomarkers with clinical outcomes in metastatic TNBC treated with pembrolizumab or chemotherapy 👉 nature.com/articles/s4152… @JavierCortesMD @ProfAnthoG @ASCOPres @Prof_Nadia_H @LoiSher 🧬 KEYNOTE-119 exploratory biomarker analysis 🔹 TILs ≥5% → ↑ ORR, PFS, OS with pembrolizumab (not chemo) 🔹 T-cell–inflamed GEP → predictive of better ORR, PFS, OS 🔹 TMB ≥10 mut/Mb → trend toward longer OS 🔹 BRCA/HRD → no predictive association 🔹 TILs + GEP show independent predictive value → immune-inflamed tumors benefit most 🧠 Clinical insight: Immune-active biomarkers (TILs, TcellinfGEP, TMB) identify TNBC subsets deriving durable benefit from pembrolizumab. @myESMO @OncoAlert @ASCO @NatureCancer @BreastCancerRes #TNBC #BreastCancer #Immunotherapy #KEYNOTE119 #PDL1 #Biomarkers #OncoTwitter
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Study across 45 institutions shows AI validity in TIL quantification for melanoma. Reproducible with prognostic validity and open-source. @tznaung 👉 jamanetwork.com/journals/jaman…
#AIinPathology #Melanoma #ComputationalPathology
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TILs Working Group retweetledi
Some studies shows how we can reduce costs based on biomarkers
SHORT-HER 9 weeks of trastuzumab is ✅ based TILS 20% or more
@TILsWorkGroup @OncoAlert #oncoalertAF @JAMAOnc⤵️
jamanetwork.com/journals/jamao…
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📄 Pitfalls in ML-based TIL assessment
🔗 doi.org/10.1002/path.6…
📄 Spatial analyses of immune infiltration in cancer
🔗 doi.org/10.1002/path.6…
#ImmunoOncology #DigitalPathology #TILs
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🎉 Thrilled to share that 2 @JPathol papers from the TILs Working Group ranked in the Top 10% most-viewed in 2023!
👏 Huge thanks to all collaborators, @JPathol & our readers for your support.
📎 Links in comments ⬇️
#TopViewedArticle #TILsinBreastCancer #pathology
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TILs Working Group retweetledi
Great slide highlighting not only are TILs predictive of pCR...it also translates to being prognostic beyond pCR for good outcome and DFS.
Seems like we have a LOT of data on TILs now, why aren't they standardly provided on path reports???🧐
#SABCS24
@SABCSSanAntonio
@OncoAlert
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🤩🍾10th anniversary TILs-Working Group at @SABCSSanAntonio 2024 - everyone welcome! RSVP here: forms.office.com/Pages/Response…
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The largest TILs-Workshop done so far! More than 100 pathologist, residents in training and medical students learning how to score TILs. Organized by the Narayana Medical College, India. Who follows? 💪🏼
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Join us for the 2024 Peter Mac Breast Cancer Medical Oncology Education Day! 📅 On Friday, 11th October, dive into the latest in breast cancer care with experts at Peter Mac or via Zoom. Registrations: shorturl.at/fpr82 @PeterMacRes @PeterMacCC
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