Poy (Tossapol) Pholcharee
83 posts

Poy (Tossapol) Pholcharee
@TPholcharee
Postdoc at Wu Lab, Biochemistry Department, University of Illinois Urbana-Champaign

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”






Excited to share our new vaccine immunogen, designed through structure-guided methods, to prevent Plasmodium vivax. While the PvDBP antigen reduces parasite multiplication when used as a vaccine, it does not protect. PvDBP is also difficult to make. Could we make it better?



This immungen elicited a high-quality growth inhibitory response. We also showed that a first dose of this highly focused immunogen, followed by subsequent doses of the broader immunogen, PfRH5, was most effective. Read all about it here: biorxiv.org/cgi/content/sh…






Stoked to share our latest pre-print! Using cryo-EM, we determined the structure of the PfRCR complex, an essential protein complex required for red blood cell invasion by the deadliest form of malaria. 🧵 biorxiv.org/content/10.110…








Congratulations to Dr @TPholcharee! Pioneer of structural biology on important vaccine immunogens used to target the malaria parasites. We are very proud of him. A Poy-aneer!




