Teijaro Lab

51 posts

Teijaro Lab

@Teijaro_Lab

Chronic viral infections, Chemical Immunology, and immuno-oncology @ScrippsResearch

La Jolla, San Diego Katılım Mart 2018

245 Takip Edilen385 Takipçiler

Teijaro Lab retweetledi

Waggoner Lab@LabWaggoner·4 Kas

Dysregulated ISG15 production and signaling during persistent LCMV infection drives lethal immune pathology, representing a therapeutic target during severe viral infections with pulmonary manifestations @J_Immunol @NamirShaabani @Teijaro_Lab doi.org/10.4049/jimmun…

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Teijaro Lab@Teijaro_Lab·24 Haz

@zakjerry1 @andyjminn @EJohnWherry @divijmathew @Isa57569543 @MdVeronika Thanks! I couldn’t find Veronika’s X name.

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Jerry Zak@zakjerry1·23 Haz

@Teijaro_Lab @andyjminn @EJohnWherry @divijmathew @Isa57569543 Also @MdVeronika

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Teijaro Lab@Teijaro_Lab·23 Haz

Congrats to everyone involved. @andyjminn, @EJohnWherry, @divijmathew, @zakjerry1 and @Isa57569543. Two great complimentary studies that hopefully will catalyze better treatments for patients in need soon! 👏

Science Magazine@ScienceMagazine

In two separate Science studies, researchers report that combining JAK inhibitors with checkpoint inhibitor immunotherapy enhances cancer patient response. Learn more ⬇️ 📄: scim.ag/7p1 📄: scim.ag/7p2 #SciencePerspective: scim.ag/7p0

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Teijaro Lab retweetledi

Nature Biotechnology@NatureBiotech·21 Haz

JAK inhibitors enhance anti–PD-1 immunotherapy by modulating T cell exhaustion and inflammatory signaling, as shown in preclinical models and clinical trials for non-small cell lung cancer and Hodgkin lymphoma.science.org/doi/10.1126/sc… science.org/doi/10.1126/sc… #NBThighlight

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Teijaro Lab@Teijaro_Lab·21 Haz

Proud of my two post-docs on their Science paper demonstrating JAK inhibitors can promote better anti-tumor responses in combination with checkpoint immunotherapy. Well done Jerry and Isa as well as all the authors! Special thanks to Dr. Veronika Bachanova for running the trial!

Scripps Research@scrippsresearch

A new @ScienceMagazine study led by Prof. John Teijaro, PhD, found that combining ruxolitinib, an approved drug, with checkpoint inhibitors supercharged T-cell responses. This could transform #cancer treatment, especially for tough-to-treat cancers. More: ow.ly/h7ol50SmP4I

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Teijaro Lab@Teijaro_Lab·8 Oca

nature.com/articles/s4158… Pleased to see this one in print. What a journey with the parker lab @_chrisgparker_! Great example of merging chemical biology and immunology to generate an exciting tool to probe the immune response. Congrats to everyone involved and all the hard work!!

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Teijaro Lab retweetledi

Chris Parker@_chrisgparker_·8 Oca

Excited to share the final version in @nchembio. Lots more mechanistic insights & characterization, including our inhibitors disrupt PPIs with mTOR components & induce lysosomal degradation of SLC15A4, & more. A promising target for autoimmune conditions. nature.com/articles/s4158…

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Teijaro Lab@Teijaro_Lab·4 Oca

Humbled to be a part of this newest venture with great colleagues Ben Cravatt, Chris Parker and Stuart Schreiber. Looking forward to what lies ahead!

FierceBiotech@FierceBiotech

Belharra Therapeutics is finally ready to rise out of stealth with $130 million in capital and a multi-year collaboration with Genentech. fiercebiotech.com/biotech/belhar…

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Teijaro Lab@Teijaro_Lab·8 Eki

Excited to share work with our lab and Parker lab @_chrisgparker_ on the development and characterization of the first Slc15a4 inhibitors. biorxiv.org/content/10.110…

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Teijaro Lab@Teijaro_Lab·29 Haz

Myeloid reprogramming by JAK inhibition enhances checkpoint blockade therapy biorxiv.org/content/10.110…

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Teijaro Lab retweetledi

Cell Chemical Biology@CellChemBiol·19 Mar

Check out the review by @_chrisgparker_ from @scrippsresearch on the integration #phenotypic #screening and #chemoproteomics, in particular using chemoproteomic-enabled libraries to streamline the #drug #discovery process dlvr.it/RvyymJ

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Teijaro Lab retweetledi

Scripps Research@scrippsresearch·16 Mar

Congratulations to @EOSaphire on being newly appointed as President and CEO @ljiresearch. A former graduate student and accomplished faculty member at Scripps Research, we wish her much success in her continued leadership in immunology and virology.

La Jolla Institute@ljiresearch

NEWS: Dr. Erica Ollmann Saphire appointed president and CEO of La Jolla Institute for Immunology bit.ly/3vFdLsb #SanDiego #LaJolla #immunology #health #biotech #biomedicine

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Teijaro Lab retweetledi

Nature Rev Immunol@NatRevImmunol·5 Mar

COVID-19 vaccines: modes of immune activation and future challenges dlvr.it/Rv2JRr

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Teijaro Lab@Teijaro_Lab·26 Ara

Merry Christmas and Happy Holidays from all of us in the Teijaro Lab!

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Teijaro Lab@Teijaro_Lab·21 Ağu

Great example of basic research at Scripps and the Calibr drug discovery engine coming together to advance medicines for human disease. Watch this space. Congrats to all involved!

Scripps Research@scrippsresearch

STING attack on #cancer! In work by @Teijaro_Lab & Lairson Lab, Scripps Research scientists discover a drug that can activate the immune-boosting protein STING. Efficacy against #melanoma shows its potential as a future #anticancer therapy scripps.edu/news-and-event… @ScienceMagazine

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Teijaro Lab@Teijaro_Lab·21 Ağu

@scrippsresearch @ScienceMagazine Perfect example of basic research at Scripps and Calibr’s drug discovery engine coming together to uncover and advance medicines for human diseases. Congrats to all involved!

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Scripps Research@scrippsresearch·20 Ağu

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Teijaro Lab@Teijaro_Lab·20 Ağu

Great day for the lab! Our collaborative work with Luke Larson's lab and Calibr came out today in Science! Congratulations to Vincent, Emily, Ying, and the whole team! We identified and characterized a novel, anti-tumor STING agonist, SR-717. Read it here: science.sciencemag.org/content/sci/36…