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The Melton Lab
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The Melton Lab retweetledi
Looking forward to keynote talks from @HansClevers, @TheMeltonLab & @GVNlab @CellSymposia #CSStemCells22 #stemcells #LosAngeles #California @CedarsSinaiMed December 8–10, 2022 Register here hubs.li/Q01rNvCk0
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The Melton Lab retweetledi
G. Oliver @NU_Lymphatics (🇺🇸@NUFeinbergMed), C. Blanpain @CedricBlanpain (🇧🇪@ULBruxelles) & D. Melton @TheMeltonLab (🇺🇸@harvardstemcell) are the guest speakers in the #ISDB2021 session “𝗙𝗿𝗼𝗺 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁 𝘁𝗼 𝗱𝗶𝘀𝗲𝗮𝘀𝗲”
Join us in 🇵🇹👉 ISDB2021.com/registration
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The Melton Lab retweetledi
Using a CRISPR screen and single cell analyses we asked how do stem cell-derived islets (SC-islets) react to immunological pressure (allogeneic). Among the hits we identified CXCL10 depletion as a way to escape immune rejection of grafted #betacells.
cell.com/stem-cell-repo…
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The Melton Lab retweetledi
Take a look at the speaker line-up for #CSStemCells22, including keynotes @HansClevers, @TheMeltonLab & @GVNlab #stemcells #LosAngeles #California @CedarsSinaiMed hubs.li/Q01d-_NX0
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The Melton Lab retweetledi
Couldn’t ask for a better closure for my postdoc era. Was so great to attend and present at #ISSCR2022! Met so many old and new friends/colleagues. Some of which you see only in meetings like these every few years. Hope to see you all next year in Boston #ISSCR2023 @ISSCR
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The Melton Lab retweetledi
Cell maturation: Hallmarks, triggers, and manipulation
@TheMeltonLab @Harvard @JuanAlvarezDom @PennCDB @IRM_Upenn @CellCellPress #ISSCR2022 hubs.li/Q01dFNRR0
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The Melton Lab retweetledi
Tomorrow 6/16 at #ISSCR2022, excited to present 'Immunogenicity of stem-cell derived islets as defined be a whole-genome CRISPR screen'. In person or virtual.
1:45pm PDT/4:45pm EDT, at 'Stem Cell Bioengineering - enhancing cell function'.
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The Melton Lab retweetledi
Happy to share a pre-print of some work from my time in the @TheMeltonLab. First and foremost, many thanks to all the co-authors involved!! Now, for a brief outline of the findings..
bioRxiv@biorxivpreprint
Secreted cytokines provide local immune tolerance for human stem cell-derived islets biorxiv.org/cgi/content/sh… #bioRxiv
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Check out our latest pre-print entitled “Whole Genome CRISPR Screening of Stem Cell Derived Islets Reveals Gene Targets for Hypo-Immunogenicity”
Elad Sintov 🎗️@EladSintov
Glad and excited to share our online pre-print of a paper submitted for peer review in @CellStemCell. We report a whole genome CRISPR screen and transcriptomic profiling of immune challenged stem cell derived islet cells. See thread below ssrn.com/abstract=40815…
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The Melton Lab retweetledi
I’ve finally settled back home in Sydney, Australia with my family. I’d like to thank Doug and all my colleagues in the @TheMeltonLab for the wonderful years together. Hope to see you soon Down Under!
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The Melton Lab retweetledi
This is just one of many good things that might happen when you listen to the Stem Cell Report. Hear more from Doug Melton @TheMeltonLab & @naleite at bit.ly/3rqVhea & read their recent paper, bit.ly/3EkcXxp. @harvardstemcell @VertexPharma @ISSCR @martinperaJAX
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The Melton Lab retweetledi
⏰ Don't miss the opportunity to hear groundbreaking research & to network with this impressive line-up of past #ISSCR presidents at the #ISSCR2022 Annual Meeting 15-18 June in San Francisco. Register by 11:59 EDT 13 April for the best rates 👉 ow.ly/oLJM50IJcqW
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The Melton Lab retweetledi
Probably the last time together with these outstanding people and outstanding mentor. Thank you @TheMeltonLab
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The Melton Lab retweetledi
It was a pleasure to participate with @TheMeltonLab on the @stemcellreports podcast. Thank you for having me!
StemCellReports@stemcellreports
👏 Our new podcast is out! Learn about the latest research & potential clinical approaches using #stemcell-based treatments for type 1 #diabetes. 🎧 ow.ly/Xe6m50IxJlU Read 👉 bit.ly/3J1nCxI @martinperaJAX @TheMeltonLab @harvardstemcell @naleite @VertexPharma
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The Melton Lab retweetledi
👨🔬Hear abt Doug Melton's latest work developing #stemcell therapies for #diabetes @ our Jerusalem symposium. His pioneering work deriving insulin-producing beta islets cells from PSCs led to the 1st in-human clinical trial ow.ly/7FAe50Im00X
@HSCRB @harvardstemcell @Harvard
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The Melton Lab retweetledi
🔬Today in @stemcellreports, research from @naleite, Douglas Melton & colleagues has identified new ways to enhance the SC-beta cell survivability through genetic manipulation of the cells. Read on 👉 bit.ly/3CeeAeR. Image: The Foundry. @martinperaJAX @TheMeltonLab
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The Melton Lab retweetledi
The Melton Lab retweetledi
“The promising results we’ve seen with #stemcell-derived islet cells could deliver a life-changing therapy for people who suffer from the relentless life-long burden of #Type1diabetes," said Dr. Douglas Melton, co-director of @harvardstemcell Institute.
The National@TheNationalNews
Sheikh Mohamed bin Zayed, Crown Prince of Abu Dhabi, provides grant to Harvard Stem Cell Institute for diabetes research #Echobox=1644321341" target="_blank" rel="nofollow noopener">thenationalnews.com/uae/science/20…
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“Meet the Scientist: Douglas Melton” on vimeo.com/442134935/9f56… special thanks to @JDRF and @TheMeltonLab team! @HSCRB
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The Melton Lab retweetledi
Are your cells mature? Does it matter? In our latest @CellCellPress, we review Cell maturation: Hallmarks, triggers, and manipulation. We discuss a new framework, based on cell plasticity, to understand how cells become specialized.. @PennCDB @IRM_UPenn
authors.elsevier.com/c/1eNDXL7PXf0d…
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