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Chuck
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Chuck retweetledi
Chuck retweetledi

Retatrutide phase 3 obesity trial just came out and the results are genuinely insane:
- 28.3% bodyweight lost on 12mg over 80 weeks
- 70.3 pounds on avg. or 31.9 kg
- 45.3% of patients hit 30%+ weight loss (this is bariatric surgery territory)
- 30.3% weight loss (85 lbs) at 104 weeks in higher-BMI patients
- 65.3% of 12mg patients dropped below the obesity BMI threshold
- 19% loss on 4mg over 80 weeks (47.2 lbs) with fewer dropouts than placebo (4.1% vs 4.9%)
- significant drops in blood pressure, triglycerides, non-HDL cholesterol, waist circumference, and hsCRP
- no cardiac or liver signals
Retatrutide is going to completely overshadow tirzepatide and semaglutide, and take the throne as the best-selling drug of all time.

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Current macros:
Protein: 250
Carbs: 350
Fat: 40
Total: 2,760 calories
Still losing fat on it, definitely not starving.
Disclosure because I think it's BS when people post their diet and talk about their results and don't say what else they're doing.
I'm on TRT 200mg of test weekly, 50mg of anavar daily and 2 iu of GH, +3mg of Retatrutide a week. The var is just temporary to preserve muscle while cutting.
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Against my better judgment, I decided to give quinoa another try. I'm a big fan of the macros, and figured maybe the last time I had it, it just wasn't made right. I ordered a salmon bowl for lunch and it had quinoa as its base.
Everything was excellent except the quinoa. Seriously, it's just not good. I forced myself to eat it all for the carbs, but otherwise I would have thrown it out.
Quinoa is just rice for sad people who hate life. Do people actually prefer this over rice taste wise, or is it all just for health reasons?
Also, diet update. I upped my carbs to 350 grams a day. Was stalling in the gym a little. Reta has made me have zero issues with jacking up my carbs. I have never been able to lose fat eating this many carbs. Hovering around 13% body fat, with an end goal of 8% just because I've never been single digit.

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@BowTiedHRT I stalled for a few weeks but once introduced MOTS-C, it kicked back on again and the lbs kept dropping
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Reta dosing, when you keep adding more mg per week and the scale stops moving.
You push the dose up. You get to the 6 or 8 mg a week level. Your protein macros are dialed in, you’re consuming enough carbs to keep your metabolism lit, and the fat loss has stalled out despite the increased Reta dosing.
The instinct here is to keep adding to the Reta dose. That’s usually a mistake, and it’s usually the point where we start feeling worse without losing anything for the trouble.
Don’t abandon the Reta: it’s doing some beautiful work behind the scenes. Pull the primary dose back a touch and bring in some Tirz alongside it. These two work exceedingly well together.
It’s not one replacing the other, it’s the two of them running in concert, and the combination tends to do what neither was doing on its own at your stalled-out dose.
Take your time finding the sweet spot with the addition of the Tirz. This is not a “load it up and see” situation.
Too much of the combination and your appetite goes, but it doesn’t stop there. Your libido goes with it and the world turns gray. Nobody is losing fat fast enough to make that trade worth it.
Start the Tirz low, give it room to tell you what it’s doing, and adjust slowly. It’s an N=1 from here. You’ll find your number.
You didn’t get fat overnight, and while GLPs are magic, there is a safe and sane way to use these compounds and I recommend keeping the weight loss to no more than 1.5lbs a week.
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Ok. Vulnerable post but here we are.
I just weighed in at 141.4 lbs.
Since Sept 2024 to today, May 15, 2026, I have lost 100lbs. It hurts to say that and share but I am going to share it because I worked so damn hard every week for over a year and a half to shed this weight. It did not happen overnight.
If it wasn’t for having this incredibly challenging goal in fighting @rondarousey I most definitely wouldn’t have reached this. I was pre-diabetic, had trouble simply walking in September 2024 and have been on the path to recovery to turn myself back into an athlete since then.
It was hard, SO damn hard.. there was so much to learn, too much to unpack here, ups, downs, plateaus, things I learned late I wish I learned earlier, trial by error but I did it.
Thank you to Ronda, who waited patiently while I lost this weight and giving me something to aim for.
There is still so much I need to learn and want to do in the health space and to continue transforming my body, but for today, I thank God, my husband and my family for sticking with and encouraging me the whole way.
I pray this encourages you wherever you are in your health journey.
Believe there is hope. Never give up.
Ok.. enough emo, I’ve got a fight tomorrow. We’ve worked so hard to get here. Tune in!!
@netflixsports
@netflix
@MostVpromotions

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@BowTiedYukon I was almost a huge pussy this morning and skipped the gym because of all the shit I have to do for an event I'm catering tomorrow then I snapped out of it and did arms and assault bike for 2 hours.
Just felt like I had to confess that I thought about it.
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110 grams can be done in one meal

Peter Yang@petergyang
I think eating enough protein daily to grow muscle is harder than actually working out
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Retatrutide 1x/week vs split dosing benefits
Great question. How I see it…
Short answer: most benefits are through AUC (area under the curve/sustained exposure), not Cmax (peak concentrations).
Long answer:
- Lipids, fatty liver, visceral fat: AUC-driven. These are downstream of sustained exposure. Things like insulin sensitivity improvements, hepatic fat oxidation, adipose lipolysis. You need consistent receptor engagement over weeks-to-months, not peaks.
Cognitive/neuroprotective:
- AUC-driven too. GLP-1 activity in the CNS for neuroinflammation and BDNF effects appears to need exposure.
Cardiovascular (BP, inflammation):
- AUC-driven for the same reason - endothelial and inflammatory changes are slow adaptations.
From what I see the only Cmax-dominant effects are appetite suppression, acute GI side effects. I personally feel the skin sensitivity with bolus weekly dosing too. Almost everything else you actually want long-term lives in the AUC bucket.
Ryan Christensen@belief_engineer
@drmarlonperalta How would CMax vs. AUC impact the secondary benefits like cognitive, lipid, fatty liver, visceral fat, etc.?
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@Jackson_HCX @9mmsmg Yep! Ive learned to take an antihistamine pill before doing my morning MOTS-C pin to minimize the bump a day or 2 later
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@9mmsmg Reta / Klow / Mots-c is my core stack that I've run for 3.5 months now.
Awesome stack, really love Mots-c but I have to keep allergy pills on hand even with a low dose due to histamine reactions.
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I post a lot about Reta because it's absolutely amazing, but I'm also on the GLOW blend. This has been an absolute game changer in my life and training.
I have dealt with major tendinitis for years off and on in my elbows from heavy benching and pressing. It was somewhat unavoidable if I wanted to continue what I was doing and I'm too stubborn not to. Waking up every morning, I couldn't fully straighten my arms. I would have to sit there and slowly extend them over a period of ten minutes, while causing extreme pain. GLOW took this away. All my tendon pain is gone. My skin is tighter on my face, making me appear younger as well. On top of it, while the Norwood reaper hasn't claimed me, when I turned 40, you could tell my hair got a little thinner and a little pushed back in corners. I now have baby hairs growing and my hair is thicker. I also bounced back from a hernia repair much faster than I should have.
I'm going on vacation, but when I get back I'm likely switching to the KLOW stack. I'm also going to be adding MOTS-C after a bunch of people I trust recommended it to me.
After that, I'm unlikely to add anything else. Just finding what works.
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@BowTiedYukon Primo the GOAT, then hes like "why's your free testosterone twice the normal range"
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@AFitTrader Its literally the driving force that gets me through my workday
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Chuck retweetledi

No gym
No equipment
Moved from
This. To this in 2 months


Ølúwâ Êzê Flâvør 🤴@Oluwa_Flavor2
No gym No equipment Moved from This. To this in 2 months
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I've been on retatrutide for about three months now. My sweet spot dose is 3 mg per week. Any more than that and I simply can't eat and I'm burning muscle because of it. In those three months, the craziest part for me has been diet discipline. I have eaten the same exact meal, 4-6x per day (non training vs training days) every single day.
Shredded chicken, rice, Greek yogurt and a steamed vegetable. I'm eating that for breakfast at 6 am all the way through dinner. I stopped even caring what it tastes like and only add a little salt for electrolyte balance. No more hot sauce, no more trying to make it taste good. I simply don't care. It tastes like nothing. I'm not intentionally depriving myself of seasoning and flavor, I just can't be bothered.
I crave nothing food wise. The only time I've even strayed from my menu was when we went to Easter Brunch. I had a piece of baked stuffed chicken instead of plain chicken, a little salmon and some roasted potatoes. When we got home I didn't even have the urge to have a piece of the cheesecake we served.
I'm fine with cutting in general, but it's crazy how effective this is. I could see people using this effectively in bodybuilding contest prep.
Testosterone is still #1
HGH is still #2
But retatrutide comes in at 3rd place.
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