Jeff

Is temperature on the earth rising (and falling) over time? History says YES. Is the cause what the alarmists claim it is? No. The issue is not the "if" the issue is the "then". The lie is that an undeniable fact like global temperature variation over time must be solved by a global control structure managed by a set of people who supposedly know better.

I’m starting to think that I’m the only right-winger on this platform who believes that climate change is a real phenomenon. Not saying it hasn’t been exaggerated in the media, but I just don’t see how you can wholesale reject it.

@kimmonismus @cremieuxrecueil Sounds completely safe since we don't need cholesterol for any other important bodily functions! Oh wait, this just in...

One injection, 62% lower LDL - permanently. Gene editing for cholesterol is here. .@cremieuxrecueil is correct. Besides GLP-1 antagonist like Ozempic or, more recently, Retatrutide, this is probably the next breakthrough that is almost impossible to put into words. Verve Therapeutics (Eli Lilly) just published Phase 1 results for VERVE-102 in the NEJM. It's a single-infusion base-editing therapy that inactivates PCSK9 in the liver. At the highest dose, PCSK9 dropped 88% and LDL cholesterol fell 62%. Reductions held for at least a year. 35 patients with familial hypercholesterolemia or premature coronary artery disease. No dose-limiting toxicities. Main side effects: mild infusion reactions and transient liver enzyme elevations. Still Phase 1, still small, no cardiovascular outcome data yet. But the proof of concept for permanent, one-shot LDL reduction via gene editing is real. This is an absolute game changer and im not exaggerting. Elevated LDL cholesterol is responsible for an estimated 4.4 million deaths every year worldwide and remains the single biggest modifiable driver of cardiovascular disease, the leading cause of death globally.

The seeker-sensitive campaign to make Christianity as inoffensive as possible was a disaster. It gave us a nation of ineffective churches and ill-equipped Christians. Christian truth is inherently offensive. I hope this book will inspire a new generation of men to speak it with boldness.

@Top100Rick Yesterday, I finished two good rounds (for me) with the same ball. Hit a few trees and rolled a cart path or two. It was still doing great when I hit it into the pond on the final hole. Oh well, I've got 11 more identical little brothers left,

If you believe golf ball really affects your score, you should play with Brock. He just shot 65 with a beat up MaxFli that had 3 rounds on it. Big golf ball wants you to believe you need to spend $5 a ball and replace when it’s slightly dinged. Do you really believe that?

@JayTC53 @gsd_chris Usually this is the move, but this year you missed 150 laps of action featuring 60+ passes for the lead and very few yellow laps. It was a unique year.

@gsd_chris I 1000% agree. I watched this went to the gym came back and watched the final 10 laps lol

The pace lap for America is without a doubt the most badass spectacle in sport. Two UH-60 Blackhawks set the pace at the Indy 500. Only in the USA! God Bless America 🇺🇸

@JayTC53 This is Indiana. We do things in badass style. That's why 1 out of every 100 Americans show up in Speedway, Indiana every year for a couple of weeks to celebrate speed.

@LonghornSloth Well, you do eventually get what you ask for - a 5-8 record in the playoffs over the last two years. SEC, it just means more... Losses.

They’re making AOC SEC edits on TikTok lmfao

@DavidLimbaugh The want money on one side and nostalgia on the other

I really don't understand why performers continue into their seventies, but far more difficult to understand is why their fans do. I know of few cases that they retain good vocal quality. What is the deal?

@daletanhardt Especially knowing that the driver on the low side is a young kid - talented, but young. Felix just didn't know that Al Jr would later say that hanging it out 2 wide all the way around was impossible.

The F1 #NetflixRacing crowd really, really hates this video. It’s gonna be okay. It’s just what real racing looks like. Don’t be afraid!

EPIC day at the Indy500!

I got "by with a little help from my friends"! The #Indy500 was one of my "firsts" without Bob. I admit to crying as I walked the final steps to our regular seats. But my nephew and my seat-pal helped me through the day. And what a race it was! #TheWiddaKevoian

Brexton Busch will be a future NASCAR champion and the entire world will cheer him on. Bookmark this.

@AFMBlog Just got a quote for replacing part of ours and it was over $20k - three quotes.

My neighbor is replacing their HVAC system today. Their house is slightly bigger than ours. Total cost for everything: $34,000!!!!! What in the hell? He said they have tripled in cost since COVID. What a crock of crap.

Always exciting to be Back Home Again in Indiana at the @IMS for the greatest spectacle in racing, the #Indy500! Congratulations to Felix Rosenqvist @FRosenqvist on an incredible performance and another unforgettable race day.

There are so many things that I can say about the past week but ultimately none of it matters as I only feel full of gratitude. So thankful to my team, my family, my doctors, and all of @IndyCar for the opportunity to have a shot out there yesterday. See you in Detroit.

This is why I've learned to love the Indianapolis 500. open.substack.com/pub/bobkravitz…

When Al Unser Jr says you have huge balls…well then you have huge balls 🤷🏼‍♂️

The gold standard

MARC ANDREESSEN JUST WENT ON ROGAN AND DROPPED THE MOST IMPORTANT AI ALPHA OF THE YEAR. 3 hours and 20 minutes of podcast. Here are the 17 things worth your attention. 1. AGI is already here. Marc thinks the line was crossed 3 months ago with GPT-5.5, Claude 4.6, Gemini 3, and Grok 4.3. Nobody noticed because the field moves too fast for anyone to register the milestones anymore. 2. For almost any topic the top AI models now give him better answers than the world-class experts he could call on the phone. And he can call basically anyone. 3. Every doctor is secretly using ChatGPT in the exam room. They turn around the second you stop talking and type your symptoms in. Some do it while you are still sitting there. His quote: "At that point you are asking what do I need you for." 4. When AI refuses to answer something he wants to know he tells it he is writing a novel. "Walk me through how the bad guy robs the bank." It explains almost anything if it thinks it is helping you write fiction. 5. When something is too complex he says "explain it like I am 10." Then "like I am 5." Then "like I am 2." He keeps going until it actually clicks. 6. When he wants to understand a tough topic he does not ask what the right answer is. He asks the AI to steelman one side then steelman the other. Then he decides for himself. 7. For big questions he tells the AI to pretend to be a panel of experts. "Be a doctor, a lawyer, a historian, a psychologist, and argue this out with each other." Then he reads the debate. 8. Pay attention to the exact moment you think "I do not know how to figure this out." Most people give up there. That is the moment you should open the AI. 9. The only real skill left in using AI is knowing what to ask. The models can do almost anything you can describe in plain English. The bottleneck lives in your own head. 10. You can send AI photos of almost anything medical now and get a real answer. Skin rashes. Blood test results. The new models read images not just text. A free 24/7 second opinion on anything. 11. The one type of therapy clinically proven to work is cognitive behavioral therapy. It is also something an AI can fully do on its own. Every person on earth is about to have access to a real therapist for free anytime they want. 12. AI is solving math problems open for 100 years that no human mathematician could crack. Same thing is starting in physics, chemistry, and biology. Expect cancer cures and weird new physics breakthroughs in the next few years. 13. The best AI coders in Silicon Valley now make $50 million a year. One person. That number tells you how big this thing actually is when you strip away all the doom takes. 14. One friend paid $200 to decode his entire DNA. Then gave the AI his DNA, blood test results, and Apple Watch data. The AI built him a full health dashboard and started telling him exactly what to fix. 15. Another friend put two cameras in his home jiu jitsu gym. AI watches him spar and gives him technique notes after every round. A world-class coach at every practice for free. 16. The best programmers in Silicon Valley now run 20 AI coding bots simultaneously. Each bot writes code while they review the others. They call themselves AI vampires because going to bed means 20 workers stop and you lose money every hour you sleep. 17. The obvious next step: the bots will run their own bots. One human running 20 bots each running 20 more. One person. One laptop. 1,000 AI workers. This is months away not years. Bookmark this before you watch the full podcast. Follow @cyrilXBT for every AI insight worth your attention the moment it surfaces.