Jeff Carrier

@chydorina Which test were you using for testing leaky gut? It wasn't just zonulin, right?

I get why you (and many other people) say that.... but...the gut is WAY downstream. Just 'fixing the gut' would lead to needing cycles of fixing the gut/gut dysfunction in all but the mildest patients. I healed leaky gut many times over the years (on paper with gut testing). Indeed, cyclical work on the gut has been part of my protocol now for years (its been ages since I noticed this pattern). The piece most people miss is that pathogens are competing with our body for minerals and nutrients. Whole body pathogen load tends to be crazily high in many of the sickest patients - they just are not reaping the benefit of food or supplements. The baseline biochemistry itself is struggling and as patients gets worse we actually start to see whole systems collapsing. So, you hit on what I would say the exact mistake I kept making was - thinking that I should focus on the gut. I am not saying all the gut stuff is not key - it is - and food intolerance/gut dysbiosis remains a major stumbling block. In many mild or recently sick patients, some lucky ones will get away with just focusing on the gut - but if the chronic illness is infection onset and includes PEM - the work tends to begin further upstream. Hope this helps.

@rudekyoni999 They're not

-Nicotine is a mitochondrial uncoupler -Increases testosterone and DHT Paired with aspirin and vitamin c cigarettes might actually be beneficial.

@hisugarfoxx @Clavicular0 This is dead on. He has created his own world, and he can create a new one

@Clavicular0 This is like going to the jungle and being upset there are too many wild animals. Look for women in other places besides the streets of Miami.

When I was in the hospital on life support a girl was begging Mitchell for my AMEX credit card (he said no). The consistent theme of girls trying to use me for money is brutal for a young guy trying to navigate a complex society. Hopefully I can find a good girl whos intent is to not to screw me over and take my money.

@SimmonsBart What's chauvanistic about this? If she enjoys doing it, then that's wonderful.

Every morning before sunrise, we get up together, brew a fresh pot of coffee, sit and talk, and read our Bibles. As I get ready for work, my wife begins her work with a grateful heart and bakes eight loaves of sourdough bread using a 100-year-old starter. The night before, she stretches and folds the dough by hand. This is our tradition—a simple, faithful rhythm that reminds us every day of God’s faithful provisions. She does it for our thirteen grandchildren, our dear friends, and the customers who count on her bread. Occasionally she makes a batch of buttermilk sourdough biscuits from my grandmother’s old recipe, and every warm bite feels like a blessing straight from the Lord. Some folks will read this and roll their eyes, calling it archaic or chauvinistic, but they don’t know my wife. She’s college-educated with a degree in accounting, a successful business owner, a seasoned bridge player, well-read, and she can still saddle her own horse and ride with the best of them. This is simply who we are—grateful, grounded, and blessed.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​ 2SRanch.com

@hatoff2you @jack_schroder_ I have a similar situation but because of MCAS. Have you tried IVs?

@jack_schroder_ There is no form of Vit C I can take, none. They all irritate, cramp or burn my gut. The only C-containing food I can consume is broccoli. Very frustrating when for decades C has been touted as so important.

Inflammation + infection depletes your vitamin C reserves — this is a big deal. You need vitamin C to recycle vitamin E, and you need vitamin E to prevent your cell + mitochondrial membranes from becoming oxidized. If you lack vitamin C, you shunt more homocysteine down the transsulfuration pathway to make more glutathione to compensate for the low vitamin C and oxidized vitamin E. This leads to undermethylation, leading to poor detoxifcation, dysregulation epigenetic programming, low melatonin, adrenaline, creatine, choline, and a lack of clearance of histamine, dopamine, and catecholamines. A lack of vitamin C leads to increased demand of CoQ10 + alpha-lipoic acid, which leads to bottlenecks in TCA cycle + ETC. If you lack vitamin C, you can't make BH4 properly, which means you can't make dopamine, serotonin, melatonin, or nitric oxide. It also means you can't make collagen, carnitine, or bile acids (tied to detoxification, fat/vitamin absorption, and antimicrobial effects). It means you can't recycle iron properly to be absorbed, nor for its role in inactivating cellular hypoxia/HIF-1a (even in presence of oxygen) You also can't govern the release/synthesis of POMC products (eg., alpha-MSH, endorphins), oxytocin, vasopressin, sex + steroid hormones, thyroid hormones, and growth hormone/IGF-1. I would suspect that most individuals who are surrounded by modern world stressors would do well with 250mg/day of vitamin C, 1-2x/day (on top of food intake + sufficient vitamin E, glycine, cysteine, protein in general). Optimize gut health + endotoxin + stressors load to ensure that vitamin C reserves stay sufficient and don't run suboptimal.

@WhiteHouse It will never cease to amaze me how much Trump openly hates America

TWO KINGS. 👑

@jsmacked @lporiginalg @avidseries Someone who acts the way he does does not deserve anyone following his requests. We all need to earn respect through having rational and honest perspectives. @avidseries constantly does that. No one else here has. No one should be interested in these emotionally charged responses

@TheeJeffC @lporiginalg @avidseries His video is public and you can watch it and criticize what's in it. But you didn't do that, you just claimed "bias!" as if that refutes anything. YOU are the bad actor and I'm not surprised he blocked you since clearly you refuse to engage with the content

This is garbage. Every data set you look at shows that political violence (especially that involving fatalities) has been mostly a rightwing problem over the past twenty years. (Property-directed political action is usually more of a problem on the left than the right.) This holds true even if you remove the problematic methodologies and assumptions (e.g., classifying Islamists and prison skinheads as rightwing) used in some of the studies conducted by ideologically-motivated organizations. More recent data show that this longer-term trend may be reversing as leftwing activity rises in volume and targeted lethality. Data from 2025 and later is still emerging and will provide a more complete picture. It's useful to remember that political violence is still a tiny percentage of all fatal violent crime. Racially and ethnically-motivated violence is far more common.

@rudekyoni999 Thats quite unhealthy. Our cell membranes are made of PUFAs in a 4:1 ratio of O6:O3. Raw seed oils, egg yolks, and seafood keep our detox, cell signaling, and cell membranes healthy

@TheeJeffC I’d avoid both as much as possible

btw that’s what omega 3 does to your mitochondria

@jsmacked @lporiginalg @avidseries His triggered response to me alone (when he also blocked me after this one gentle comment) indicates he is not a person of pragmatism and calamity, but rather is emotionally driven. We have to start calling bad actors out.

@TheeJeffC @lporiginalg @avidseries "You have a bias" is not a refutation of someone's point He linked his work, you can counter that work, but a blanket claim of bias isn't a counter. If it were then Hypocrite's video could be 3 seconds long with him saying "they're biased"

@Chesschick01 We?

I'm with Rand and Trump on this one. We need a Ballroom.

@adammocklerr This is as dumb as when people say its a left problem. Get off the internet, people.

Political violence is not a “both-sides” problem. It’s also not a fringe problem. It comes from the mainstream Right.

@holisticgrenade 34k people follow this kid. For those who do- why?

I'm convinced that the average anti-vaxxer mom who gets all of her information from her phone while sitting on the toilet knows more about nutrition and pharmaceutical products than the average doctor. This is because doctors don't learn anything about nutrition and all of their education on pharmaceutical products is actually just sales training.

@IsabellaMDeLuca Yes. This is a totally sane and rational take

Feminism is a scam designed to get women into the workforce so they could tax both parents and indoctrinate your kids at school.

@IsabellaMDeLuca You're an intensely broken person to make that conclusion from this data point. Waaaaaaay too online.

The crazier the world gets, the more I realize the importance of the nuclear family and its impact on society— which makes sense why the Left has used things like feminism to destroy it. They know that when a Mother is absent from the home she can’t raise her children. When she can’t raise her children, the internet and Government do.

@chydorina Thats money. Thanks.

@TheeJeffC x.com/algekalipso/st…

Yesterday's article showing how Ambien/a z-drug ( benzodiazepine type sedative) negatively affects glymphatic clearance needs to be addressed and the potential consequences need to be carefully deconstructed especially in light of how common their use is in MECFS LongCovid and other chronic illnesses. Its not fearmongering. I do think there is a major issue here and improper use might be one of the most dangerous things we can do in terms of our long-term cognitive health. Its not just glymphatic clearance that is being negatively affected. Benzo-type sedatives also affect brain wave patterns. Studies from way back in the 60s showed that they increased beta waves. Its a paradoxical effect - we feel like we are less anxious when we are on them but our brains are actually in fight-flight. This recent paper on the negative effects of Ambien (which will likely apply to more benzodiazepine type drugs) on glymphatic clearance is a major issue especially in MECFS. Pretty much the only intervention we know of that can help reduce the severity of PEM crashes from developing when used in moderation and very infrequently has potentially disastrous consequences if used improperly long-term. And this is not even taking into consideration the potential for serious adverse consequences of withdrawal and how difficult it is for people who have been on them for prolonged period to stop. I was put on benzos (both Clonazepam and Lorazepam) for over a decade, with full physician oversight and was told that I would likely always need to be on them (I started prior to my second bout of MECFS). The reason was constant sympathetic nervous system overactivation (c-PTSD). Tapering and getting off of them took years in my case. I am now at a place where I can use lorazepam infrequently and do so for major crash inducing activities - but I try very hard to keep my use lower than a few times a month. I would think this issue would be getting WAY more attention than it does - I guess we are all just too afraid to discuss it (let alone think about it) given that it is considered the only option my many people for PEM crashes and sleep. The risk:benefit however is very seriously on the side of risk - especially when used daily for long periods of time. The bottom line here is that we just dont know how risky this medication might be in terms of long-term cognitive decline - but the literature is stacking up that the risk might be very considerable. Sleep dysfunction and glymphatic clearance are among the biggest potential issues in MECFS that make recovery difficult. Without proper sleep we cannot heal. Many of us use these medications for sleep as MCAS and histamine and mast cell dysfunction directly affects our circadian rhythms and increases insomnia and its the only thing that helps. I know many of us would be seriously hooped if we didnt have access to benzodiazapines. Finding alternatives is of paramount importance and should be one of the very top clinical priorities in MECFS and LongCovid research. We should not be forced into taking a drug that can lead to cognitive decline and dementia (the potential ultimate consequence of dysfunctional glymphatic clearance as is suggested by much of the literature) to help us sleep and help control the severity of PEM. That this is literally the only option that is available and it is potentially this damaging when used long-term and continuously is frankly completely unacceptable. Like using chemo to treat cancer, how much unnecessary damage are we doing to ourselves - under the guise of 'treatment'. I know this issue will be very scary for people to think about and i apologize as I know this will be triggering for a lot of people because there really are no good options. But, it is too important to sweep it under the rug and we do need to discuss it. How can we use benzo-type drugs are safely as possible given the potential consequences for glymphatic clearance and long-term cognitive decline should be a big conversation. Is there any safety margin or dose or is their use keeping us stuck in chronic illness and decline. x.com/chydorina/stat…

@St_Equanimity @HistoryBoomer @amazingnature @itsme_urstruly Thanks a lot!

@TheeJeffC @HistoryBoomer I enjoy @AMAZINGNATURE and Wholesome Side of X @itsme_urstruly, among others.

Most folks in America, left and right, are not evil. Most folks on Twitter are deranged.

@AllieBullivant @JoelWBerry They think people being subjected to an array of ideas and having opinions challenged is liberalism, i guess. I returned to college as a non-trad and the only political influence on campus was pro Trump

@JoelWBerry I’m a public school teacher. English & Government. I do NOT agree with this guy. Nor do I advocate for political violence. My students just spent 4 weeks learning about MLK Jr and constructive non-violence. Don’t paint all public school teachers as ignorant, faux-activist shits.

It’s likely that the majority of public school teachers you leave your kids with all day agree with this guy

@JoelWBerry Even though this has been proven false, what are you trying to accomplish with that, prevent all conservatives from putting their kids in school? The education gap is bad enough as it is

@rudekyoni999 Dis you read this paper? Anything of note in there?

coke a day,keeps the doctor away? a 82 yo diabetic women with severe abdominal pain, had not passed stools for a few days came to the hospital. CT scan shows a large fecaloma(dehydrated stool). - 2L of Coke is given - “resulting in a significant reduction in the size of the faceloma -“return of bowl function” Coke is effective treatment for constipation and dehydration, I personally aim for 1L a day.