Benjamin Thoreau

Happy to share this great collaboration about anti-fibroblast & anti-endothelial cell #autoantibodies in pulmonary arterial hypertension in patients with connective tissue diseases (CTD) | Rheumatology Oxford ⁦@InstitutCochin⁩ ⁦@mouthon_luc⁩ academic.oup.com/rheumatology/a…

Upadacitinib Versus Tofacitinib in Anti-MDA5-Positive Dermatomyositis With Interstitial Lung Disease: A Multi-Centre Cohort Study Emulating a Target Trial onlinelibrary.wiley.com/doi/10.1002/re…

In a phase 3 randomized trial involving 3208 children with Kawasaki disease, adding prednisolone to standard primary therapy did not reduce the incidence of coronary-artery lesions at 1 month. Full trial results and Research Summary: nejm.org/doi/full/10.10…

Blinatumomab & teclistamab may offer potential as rescue therapies for patients with treatment-refractory ASyS and SSc, but requiring controlled trials to confirm efficacy, durability and safety. #SSc #ASyS #CTD #ILD #citeas" target="_blank" rel="nofollow noopener">nature.com/articles/s4159…

Landscape of somatic mutations in a large cohort of Chinese patients with immune dysregulations acrjournals.onlinelibrary.wiley.com/doi/10.1002/ar…

Happy to share our new study "A Proof of Concept for the Use of Lung Ultrasound in the Diagnostic Approach of Pulmonary Hypertension" published in CHEST Pulmonary @pulmotension @SPLF_SocPneumo @InsermU999 @HTaPFrance chestpulmonary.org/article/S2949-…

Blinatumomab in Combined Immune Thrombocytopenia and Antiphospholipid Syndrome | New England Journal of Medicine nejm.org/doi/full/10.10…

ELISA testing revealed anti-CD146 autoantibodies were more prevalent in patients with systemic sclerosis than controls. Anti-CD146 autoantibodies were also associated with occupational dust exposure ACR Open Rheumatology acrjournals.onlinelibrary.wiley.com/doi/10.1002/ac…

Eosinophilic myocarditis ahajrnls.org/3Zii2BM

Very important data!

Whole exome sequencing study identified 7 rare/novel RELA variants in patients with a broad range of immune diseases. RELA may be a contributing factor in cases of complex autoimmunity Arthritis & Rheumatology doi.org/10.1002/art.70…

MMF is commonly used to treat fibrotic subsets of SSc but uncommonly used in limited cutaneous SSc. This analysis showed patients with limited cutaneous SSc treated with MMF had reduced need for escalation of vasoactive or vasodilator therapy, suggesting a possible vascular-protective effect of MMF AC&R doi.org/10.1002/acr.70…

Review of IL-1 family cytokines in inflammation and immunity - including, IL-1, IL-18, IL-33, IL-36, IL-37, IL-38, IL-1Ra, etc. Full read -- Good Reference!! buff.ly/jmT18rl

EBV and SLE: causal or concurrence? Read our Jan 2026 editorial bit.ly/49hm6I4

A new Science #Immunology study finds that juvenile #axolotls can regenerate their #thymus from scratch after complete removal, which could inform future therapeutics for aging or immune-compromised patients. scim.ag/4pih6Zw

TriNetX retrospective cohort study of 1402 propensity matched Systemic Sclerosis pts on vs off SGLT2 inhib (2013-2025) & found SGLT2i significantly lowered all-cause mortality (HR 0.54), stroke (HR 0.64), & hospitalizations (HR 0.76), moreso in SSc without Hx of CHF (HR 0.62) buff.ly/hTp9gGF

Randomized phase 2 trial of pirfenidone (PFD) or placebo along with MMF in SSc-ILD: doi.org/10.1002/acr2.7… • no statistically or clinically significant difference in FVC% improvement from baseline • mean time to ≥3% improvement in FVC% was numerically shorter with MMF+PFD • MMF+PFD assoc. with better improvement in PROMIS-29 physical function • AEs, including serious AEs, more common with MMF+PFD • low recruitment limited statistical power

Is fibroblast proliferation important in pulmonary fibrosis? Finally an answer - great paper by the super team of Christopher Molina,Tatsuya Tsukui, and Dean Sheppard #זScienceMatters #CureIPF jci.org/articles/view/…

We're glad to share this article published in @Hemasphere_EHA showing that mutations in IDH (IDH1/2) can act as drivers of inflammation. onlinelibrary.wiley.com/doi/10.1002/he…