DRMP
423 posts

DRMP
@DRMP2025
Assistant Prof @nyugrossman @Perlmutter_CC | Somatic mosaicism in cancer & aging 💻🔬 Opinions my own. Also at: https://t.co/au1Q3tFHF7
New York, USA Katılım Temmuz 2018
467 Takip Edilen1.3K Takipçiler
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Excited to share our paper out today in @ScienceMagazine! We directed high-content, single-cell genetic screens to ask how a disordered adapter protein orchestrates the complex process of T cell activation. (1/4)
science.org/doi/10.1126/sc…
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We're in this week's Nature! We propose a model of how a cell learns by running an evolutionary algorithm: exploring different gene-regulatory combinations and using feedback responses to stabilize those combinations that reduce stress levels.
Full text: nature.com/articles/s4158…

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Only half of esophageal adenocarcinomas (EACs) are associated with background Barrett esophagus (BE). New integrated epidemiological & molecular data from @RFitzgerald_lab reinforces commonalities between the two reiterating that BE is universal precancer.
nature.com/articles/s4159…

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Excited to share our latest work. Applying advanced single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune lymphocytes. [1/n] rdcu.be/fdqbr
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latest from the lab --> how we used whole genome passenger somatic mutation patterns 🧬 to trace the origins of never-smoker lung adenocarcinoma (LUAD) to cells of the proximal lung 🫁 @NatureGenet nature.com/articles/s4158… 1/🧵

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Honored to be part of the 2025 class of #PackardFellows ✨ and deeply grateful to the Packard Foundation for supporting bold science that advances knowledge and real-world impact 🌎🧬🙏 packard.org/2025fellows

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@DRMP2025 Wonderful news… congrats Mia & Petljak lab!! 🚀
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Big, beautiful trees!!
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
biorxiv.org/content/10.110…

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@AACR Seeing friends and gushing about our shared love for DNA 🤓🧬😃🤟@TimCoorens @imartincorena @ivazquezgarcia #AACR25

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Some trully trainee led science! @Elsa2Bernard @oriol_pich Maria Zagorulya - our work is done here!
Read how CH can influence solid tumor progression & treatment response ⬇️
@NEJM with the one & only @CharlesSwanton
@MSKCancerCenter @TheCrick
Oriol Pich@oriol_pich
🚨Thrilled to share our latest work: “Tumor-Infiltrating Clonal Hematopoiesis” @NEJM - we investigated how age-related blood mutations impact cancer when they infiltrate tumors, with @Elsa2Bernard Maria Zagorulya, @PapaemmanuilLab @CharlesSwanton + more nejm.org/doi/full/10.10…
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Excited to share our exploration @naturemethods into new horizons opening up in the era of low cost sequencing!
🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD
🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA
Check out thread 👇
Alexandre Pellan Cheng@AlexandrePCheng
What happens when sequencing costs go ⏬ ? Imagination and new opportunities go ⏫ @landau_lab Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the @UltimaGenomics platform 🧵👇 Lets goooo!! rdcu.be/ehkUb
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🚨OPEN POSTDOC
POSITION in our brand new lab space by Madison Sq NYC ! 🌆🧬🔬
Do experiments, learn computation, and uncover drivers of a major mutational process affecting >50% of cancers, driving therapy resistance & impacting immunotherapy responses👇
#apobec" target="_blank" rel="nofollow noopener">med.nyu.edu/research/postd…
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