Tim Lohoff

93 posts

Tim Lohoff

@Tim_Lohoff

Life Science Venture Capitalist @ForbionLifeSci | Ph.D. in Stem Cell Biology & Medicine from @Cambridge_Uni @ReikLab

Munich, Bavaria Katılım Şubat 2017

444 Takip Edilen268 Takipçiler

Tim Lohoff retweetledi

Ruslan Rust@rust_ruslan·8 Nis

New preprint! 🚨@KeckMedicineUSC @uzh_irem We started with the simple question: What happens when we transplant stem cells into a mouse model of #stroke, and what are the interactions between graft and host? Took us only 5 yrs to find out😀: biorxiv.org/content/10.110… 1/10 🧵

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Tim Lohoff@Tim_Lohoff·20 Mar

@BowTiedBiotech @zhaoweiasu Have a look at the original publications and as I said, stay tuned and watch out for the space!

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BowTiedBiotech 🧪🔬🧬@BowTiedBiotech·20 Mar

@Tim_Lohoff @zhaoweiasu How does one define an endogenous target site? Do you still need to include a promoter into the payload with this system? Or can land under control of WT promoter?

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BowTiedBiotech 🧪🔬🧬@BowTiedBiotech·16 Mar

🧬 🇩🇪Full Gene Insertion: we have been watching this one - was not aware of the rename - Seamless Tx! Congrats! #biotech endpts.com/german-biotech…

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Tim Lohoff@Tim_Lohoff·20 Mar

@BowTiedBiotech @zhaoweiasu Seamless can program recombinases to almost any endogenous target site, without the need for a prior installed landing pad. The site-specific recombinases can ultimately catalyze inversions, insertions, excisions, and exchange reactions. Stay tuned!

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BowTiedBiotech 🧪🔬🧬@BowTiedBiotech·20 Mar

@Tim_Lohoff @zhaoweiasu But still limited by safe harbor landing/integration?

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Tim Lohoff@Tim_Lohoff·18 Mar

@BowTiedBiotech @zhaoweiasu Just to clarify, Seamless is using recombinase-based gene editing, not retrotransposons, even more versatile 💪🏼

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BowTiedBiotech 🧪🔬🧬@BowTiedBiotech·16 Mar

@zhaoweiasu I have many questions about retrotransposon specificity - it would seem to me they limited to landing within safe harbours which comes with risk...

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Tim Lohoff@Tim_Lohoff·27 Oca

@luketgharland @wellcometrust @SCICambridge Great news and well deserved!!! 🥳

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Luke TG Harland@luketgharland·27 Oca

It’s official! I’m delighted to share that I’ve received a 5-year Early Career Award from the @wellcometrust to study the role of developmental history in settings of molecular convergence @SCICambridge (wellcome.org/grant-funding/…) 1/3

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Tim Lohoff retweetledi

Reik Lab@ReikLab·12 Oca

New preprint! 🥳 biorxiv.org/content/10.110… Led by @AledJohnParry & @ChristelKrueger we asked why #DNAmethylation and oxidation often target overlapping genomic regions at the exit of #pluripotency. Great collaboration with @Tim_Lohoff, @StevenWingett & @stefanschoenfe1. 🧵👇

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Tim Lohoff@Tim_Lohoff·29 Eyl

@shazanfar @GenomeBiology @RArgelaguet @ReikLab @SCICambridge @Cambridge_Uni @BabrahamInst Thanks, Shila 😊

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Shila Ghazanfar@shazanfar·29 Eyl

@Tim_Lohoff @GenomeBiology @RArgelaguet @ReikLab @SCICambridge @Cambridge_Uni @BabrahamInst Wonderful news!! Congratulations 🥳🥳🥳

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Tim Lohoff@Tim_Lohoff·29 Eyl

Happy to see another piece of my PhD work published in @GenomeBiology! 🥳 Amazing collaboration with @RArgelaguet and Stephen Clark 💪#DreamTeam Big thanks to everybody involved @ReikLab @SCICambridge @Cambridge_Uni @BabrahamInst! Finally, check out the great tweetorial below 👇:

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Tim Lohoff@Tim_Lohoff·1 Ağu

Great work @rust_ruslan and team! 🙌🐭

Ruslan Rust@rust_ruslan

Preprint 🚨 How does immune suppression alter the molecular 🧬 and anatomical 🧠 roadmap of #stroke pathology? We detect distinct changes in different pharmacological and genetic immunodeficient models of stroked mice 🐭⚡️💉 Read more here: biorxiv.org/content/10.110… 🧵👇🏽 1/11

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Tim Lohoff@Tim_Lohoff·14 Nis

@felix_lansing Congrats and best of luck 🥳

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Felix Lansing@felix_lansing·14 Nis

I'm looking forward for our journey!

RecTech@RecTech_Dresden

Yesterday we founded RecTech GmbH (i. Gr.)! This is a big step forward on the way to develop designer recombinases for clinical applications. All of it wouldn't be possible without such a great team @BuchholzLab_TUD. Looking forward to the exciting times ahead!

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Tim Lohoff@Tim_Lohoff·25 Şub

@JTaubenschmid @CellStemCell Congrats Jasmin et al. 🥳 Great to see the final product!

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JasminSTowers@JTaubenschmid·24 Şub

Happy to see this out in @CellStemCell! 8C-like cells capture the human zygotic genome activation program in vitro. Details here 👉 cell.com/cell-stem-cell…

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Tim Lohoff@Tim_Lohoff·20 Oca

Wow 🤯 Congratulations @felix_lansing and team 🎉 Amazing work. Looking forward to following the path of designer-recombinases towards the clinic 🩸💪🏼 Keep the exciting work up! 🍀 Check out the great tweetorial below 👇

Felix Lansing@felix_lansing

Our work just got published in @NatureComms. We developed a dual designer-recombinase system that efficiently corrects a 140 kb inversion frequently found in patients with severe Hemophilia A. 1/11 @BuchholzLab_TUD @TakebeLab @tudresden_de @Medizin_TUD rdcu.be/cFmeD

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Tim Lohoff retweetledi

Yodai Takei@yodai_takei·30 Eyl

Our work is out in @ScienceMagazine! Using integrated spatial genomics technology, we have extensively investigated the single-cell nuclear architecture across cell types in the mouse brain cortex with a great team @LongCai_Lab @gc_yuan @swzheng29 #seqFISH science.org/doi/10.1126/sc…

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Tim Lohoff retweetledi

Shila Ghazanfar@shazanfar·13 Eyl

Incredibly happy to share that our work, co-led with @Tim_Lohoff is now available online at @NatureBiotech 🎉 Feeling very grateful to everyone who was involved in this project 🙏 Explore the data here: marionilab.cruk.cam.ac.uk/SpatialMouseAt…

Nature Biotechnology@NatureBiotech

Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis go.nature.com/3DRM6rY

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Reik Lab@ReikLab·7 Eyl

Paper alert! 🎉 By combining SeqFISH and scRNA-seq data we've generated a spatially-resolved map of cell types and gene expression in the early mouse embryo. doi.org/10.1038/s41587…

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Tim Lohoff@Tim_Lohoff·12 Eyl

@RichTyser @shazanfar Thanks for all your help! 💪 #TeamWork

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Richard Tyser@RichTyser·8 Eyl

Congrats @Tim_Lohoff and @shazanfar!

Reik Lab@ReikLab

Paper alert! 🎉 By combining SeqFISH and scRNA-seq data we've generated a spatially-resolved map of cell types and gene expression in the early mouse embryo. doi.org/10.1038/s41587…

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Tim Lohoff@Tim_Lohoff·12 Eyl

@felix_lansing @ReikLab Thanks Felix 🙏

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Felix Lansing@felix_lansing·8 Eyl

@ReikLab Congrats to you @Tim_Lohoff and the team!

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Tim Lohoff retweetledi

Cai Lab@LongCai_Lab·7 Eyl

Our work "Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis" is now out at @NatureBiotech ! Congratulations to all the authors! nature.com/articles/s4158… #seqfish #spatial #singlecell #transcriptomics

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Tim Lohoff retweetledi