Open Toed Shoes

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Open Toed Shoes

Open Toed Shoes

@ToedOpen

Couch potat

Los Angeles, CA Katılım Ekim 2022
665 Takip Edilen50 Takipçiler
Mike Bales 🫡🇺🇸
Another sketchy ‘proof of life’ pic from Mitch. Hey doctors and nurses — what’s wrong with this photo? When did they start posting room numbers on the inside and hang charts on the side of the bed?
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Open Toed Shoes
Open Toed Shoes@ToedOpen·
@Acyn Didn't know who you were before this Brad but welcome to the primary list.
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Acyn
Acyn@Acyn·
Sherman on Massie Amendment: If you care about not only our Middle East policy, but you care about the Democratic party's position with the American people, then you must vote no on this amendment. This is an attack on the Israeli people.
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Open Toed Shoes
Open Toed Shoes@ToedOpen·
@Realitytv__fan Colin's descriptor is "Kate Gosselin's Son" :D I guess that prepares him for the torture but they could've said former TV personality or something.
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Open Toed Shoes
Open Toed Shoes@ToedOpen·
@HousewivesHub Of course there’s a filming schedule. You think they show up at Nobu with cameras, crew and lighting unannounced?
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Bye Wig Hello Drama
Bye Wig Hello Drama@HousewivesHub·
Katie Ginella is sharing more about her experience filming The Real Housewives of Orange County. She revealed that production gives the cast a weekly filming schedule, which outlines who they’re filming with, what they’re doing, and where they’re going. Katie said production told her she would be taking Gina, Jen, and Emily to an Asian grocery store, so she assumed it would be somewhere like H Mart. However, when she arrived, she realized it was a Japanese grocery store. Katie said she told producers that she’s Korean, not Japanese, and didn’t feel comfortable pretending to be knowledgeable about Japanese culture. According to Katie, production brushed off her concerns and told her to “just make it work.” Katie said she didn’t want to walk into the store and act like she knew all about Japanese culture when she didn’t, adding that production gave her a lot of pushback over her concerns. Katie also revealed that production would sometimes tell her to say and do certain things during filming. She claimed producers even interrupted one scene to tell her to bring something up. Podcast: Pink Politics #RHOC
Bye Wig Hello Drama tweet media
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Open Toed Shoes
Open Toed Shoes@ToedOpen·
@epicberserker @Variety I agree with that but if he holds for the deal to close (supposedly sometime this Q) he'd get $4 per share more. I'm curious why he's leaving millions of dollars behind and if it implies anything about the deal?
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epicberserk3r
epicberserk3r@epicberserker·
@ToedOpen @Variety He just wanted to sell the whole time only reason why he bought warner Bros to acquire with his discovery at the time
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Variety
Variety@Variety·
David Zaslav has filed to sell another $59.5M worth of Warner Bros. Discovery stock: • The filing comes after the CEO disclosed plans to sell $114M worth of WBD stock in March • With the sale of Warner Bros. Discovery to Paramount, Zaslav's net worth is estimated to exceed $1 billion variety.com/2026/film/news…
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Open Toed Shoes@ToedOpen·
@Jay_1_7 They literally had to spell out that they made this all happen for her. I feel like it was a way to tell her to adjust your attitude without saying it.
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Ak
Ak@Jay_1_7·
This is soo weird from the producers , why mention KC in Aniya’s final date , always finding ways to just throw shade , hate this shit 🫩 #LoveislandUSA
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Political Polls
Political Polls@PpollingNumbers·
Bill Clinton chief strategist James Carville: "Bernie Sanders is the reason Donald Trump became president."
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Cory Booker
Cory Booker@CoryBooker·
I am stunned by Senator Graham's passing, and thinking back this morning about some of the work we did together. My prayers are with his family and all who cherished him. Rest in Peace.
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Open Toed Shoes@ToedOpen·
@loveislandusa Could we not let KC have his well-deserved redemption arc? He stayed true to himself and found love. None of the final four seem legit but I’m voting Brinity simply based on the fact that Bryce seems more decent than the rest of the men.
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ABC7 Eyewitness News
The Los Angeles Unified School District could run out of money within about a year and is showing severe signs of financial distress, according to county education authorities. The nation's second-largest school district, which serves more than half a million students, is facing possible insolvency. abc7ne.ws/PojTHl
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𝗠𝘂𝗵𝗲𝗲 ♛
𝗠𝘂𝗵𝗲𝗲 ♛@muheediva01·
Be Honest…How much rent were you paying in your very first apartment? I’m tryna see how cheap life used to be.
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Open Toed Shoes@ToedOpen·
@CNN He can ignore that like he’s ignored the actual assassination attempts.
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CNN
CNN@CNN·
Israel shared intelligence with the US that Iran had devised a new plan to assassinate President Donald Trump, two sources familiar with the matter told CNN. cnn.it/3Tt1APd
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Drop Site
Drop Site@DropSiteNews·
CNN says Michigan Senate candidate Abdul El-Sayed has launched a website that plays his opponent, U.S. Rep. Haley Stevens’, remarks about Israel on an endless loop. “Israel comes to me in my dreams,” Stevens says, over and over again. The website is linked below.
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Open Toed Shoes@ToedOpen·
@bryan_johnson You guys are doing it - you’re really going to find treatments for endometriosis
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Bryan Johnson
Bryan Johnson@bryan_johnson·
🚨Kate officially diagnosed with endometriosis > done without surgery > across three modalities: imaging, blood, and AI > all non-invasive > in 42 days For context, average time to diagnosis is 6.6 years. And, we found 2 other diagnoses at the same time. Over the past 6 weeks, we’ve sprinted to confirm or deny Kate’s suspected endometriosis. Endo is notoriously challenging to diagnose. It’s one of the most gnarly diseases and affects 15% of women. Men, to get you on the same page, having endo is akin to an alien growing in your guts and balls, self replicating, and glueing everything together. Causing you constant pain and discomfort. We got to work. > got an MRI > got a transvaginal ultrasound > both results came back negative At this point, Kate’s patient journey had followed the archetype precisely. Most women don’t get diagnosed for 7-10 years. For Kate, it’s been 7 years. And, like most women, her imaging came back clear even though now we know that she has endo. This is why diagnosis has traditionally happened via surgery. There has been no other way than to open her up and look inside. We wanted to avoid surgery so we went back to the drawing board. We searched the world over. On our second go, we did: > endo-specific ultrasound > an endo blood test > AI MRI > saliva test This was successful. We were able to confirm her endo via ultrasound, blood test, and MRI. Confirmed simultaneously by three unique modalities, as far as we know, a world-first approach. The extensive measurement allowed us to find additional things. Her ultrasound showed: > endometriosis > PMOS (formerly PCOS) (needs confirmation) > adenomyosis 30-40% of women have at least one of these conditions. That’s intimidating especially when the path to diagnosis is fraught with so many challenges. Phase I was getting a diagnosis. Phase II is curing endometriosis. We’ve already started working. If you’re a female with suspected endo, here’s what you can do to accelerate your diagnosis. — 1. Endo-Specific Ultrasound You want an endo-specific ultrasound. As we saw with Kate, a standard pelvic/transvaginal ultrasound failed to identify her endo. You want the ultrasound to be performed by a physician or sonographer specifically trained. They follow a special protocol to hunt for endometriosis by mapping the ovaries and uterus, and testing whether organs can slide freely, or are tethered by endometriosis lesions. It’s best timed just after ovulation, when a small amount of peritoneal fluid aids visualization. It can detect superficial endometriosis, lesions, and adenomyosis that general imaging misses. We went to Dr. Kacey Hamilton at Cedar Sinai. 2. AI MRI / MatricesAI Radiologists miss lesions in up to 60% of cases. We worked with @MatricesAI which leverages AI and a unique dataset to detect endometriosis lesions on pelvic MRI. This model is still new, its first pilot study with 200 participants began in April this year. Here is how you can work with them: They’re opening their diagnosis program at the Geneviève Institute to give early access to their AI model in a clinical trial. They will take you through a state-of-the-art clinical intake questionnaire. Help you advocate for your symptoms with your gynecologist, based on your intake or connect you to a new center where their AI is being piloted and the clinical trial conducted. 3. Blood test / HerResolve Kate had two small tubes of blood drawn for a test built by @Heranovalifesci. The test measures seven biological markers (three microRNAs, three proteins, and one hormone) and uses an AI model to help detect endo. It was highly accurate in its validation study at confirming endo and caught most cases that ultrasound and MRI had missed. Their technology has been validated in a peer reviewed study (298 women, 11 sites across US/Europe/Hong Kong, published in the Journal of Minimally Invasive Gynecology): specificity 97.5%, sensitivity 80%, with strong diagnostic performance (94.4%), demonstrating it was highly effective at distinguishing women with endometriosis from those without the disease. A positive result is a strong signal, since only 2.5% of women without endometriosis test positive, though final confirmation is still clinical. A negative is less conclusive, because the test misses about 20% of true cases. The test identified 61.5% of histologically confirmed cases that transvaginal ultrasound and/or MRI missed. # We did one more saliva based test and will report back on that when results are returned.
Bryan Johnson@bryan_johnson

Examining Kate’s 1% She has suspected endometriosis. This affects at least 1 in 10 women, likely more. Here she’s getting an ultrasound. Historically you needed surgery just to diagnose it (incisions are made in the abdomen). We're doing a non-invasive route. Typically women live with endometriosis for 7-10 years before being diagnosed. It’s the leading reason women aged 30 to 34 get hysterectomies (permanent surgery to entirely remove the uterus). This condition is where endometrial-like tissue starts growing outside the uterus, in ovaries, bowel, bladder, even the diaphragm. This tissue inflames, scars, and glues organs together. Our first step is to find out if @_katetolo has it. Initial measurements we’re doing: + trans vaginal ultrasound + pelvic MRI w and w/o contrast + hormonal labs All during the early part of her cycle to get the clearest picture. During her ultrasound, a slim probe, about the width of two fingers, 10-12 inches long (although only a small portion is inserted) is covered with a protective sheath and lubricant and gently inserted into the vagina (patient has to empty their bladder first). This creates real-time images of the uterus, ovaries, and surrounding pelvic structures. While inserted, the probe is turned 90 degrees to evaluate all the various structures, angles and views. There is no radiation exposure. The technician is looking for scarring, ovarian cysts, adhesions, and for organs that are fused together with tissue. This ultrasound can confirm endometriosis but it cannot rule it out. What endo does to the body: + 90% report pelvic pain + 50% report severe fatigue + 26% report infertility. However many sources cite 30 to 50 percent. + 50% experience pain during sex. + Many have pain with ovulation, bowel movements, and urination + Severe bloating called “endo belly” where the abdomen visibly distends There are a handful of theories about why endometriosis develops but the honest answer is no one is quite sure. We’ll keep you posted on her results.

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