Triptesh Kumar Roy

Nature research paper: Decarboxylative alkylation of alkenes go.nature.com/3QEvX3Y

@ChinmoyKHazra1 @ChandrikaGhos19 @Nature Thank you very much

@TripteshR @ChandrikaGhos19 @Nature Congratulations

Our work on decarboxylative alkylation of alkene is now online in @nature

@mato_mauro @g_laudadio @Nature We did not really try to see can we use it as a general electrophile to form organometallic species. But It can be a good idea to look in to that aspect.

@g_laudadio @TripteshR @Nature I also found this RAE OA to Zn fascinating. Is this a general way to access organometallics? Also, why do more reducing metals (Mg, Li..) fail ? Does the organometallic not form, or is it just that alkyl-Mg/Li is not active in this coupling? Huge congrats, amazing discovery!

@mato_mauro @g_laudadio @Nature Hi Mauro, thanks. Alkenyl-TT is easy to reduce. Even with zinc we can see slow reduction. Using metals with lower reduction potential (Mg/Li) is not so helpful in that way, also alkylzincs are more tolerating towards many functional groups, and suitable for transmetallation step.

Our alkene alkylation strategy has been featured in @cenmag! cen.acs.org/synthesis/alke…

@Teja_Chitrala Thank you Teja anna

Nice work, big congratulations Triptesh 🎉

@itsAD09 @Nature Thank you

@TripteshR @Nature Congrats🎉

@SayanRoy16 @Nature Thank you sayan da

@ArkaSinha14 @ritter_lab @Nature Thank you Arka

@TripteshR @ritter_lab @Nature Congratulations @TripteshR 🎉

@rachit4499 @Nature Thank you Rachit

@TripteshR @Nature Congratulations @TripteshR 🙌🎉

@WaskeShivam @Nature Thank you Shivam

@TripteshR @Nature Hearty Congratulations 🎉🎉

@i_am_mangish @ritter_lab @Nature Thank you Mangosh

@TripteshR @ritter_lab @Nature Congratulations 👏🎉

@i_am_mangish @ritter_lab @Nature Thank you Mangish

@g_laudadio @Nature But if you use Pd/Zn system Pd(0) or Pd(II) is less likely to hamper RAE. Zn is going to reduce RAE. So there is a high possibility of observing alkylzinc species in polar aprotic solvent.

@g_laudadio @Nature Hi Gabriele, I think when Ni/Zn system is used for general C(sp2)-C(sp3) XEC, it proceeds through radical pathway. Ni(I) reduces RAE at a much faster rate than metallic zinc. So probably alkyl radical (or alkyl-Ni, after ligation) is key there.

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New method for N-arylation of amines in DNA-encoded libraries! Using ruthenium-mediated pi-arene activation, aryl halides are activated, then undergo SNAr followed by photolysis to give the N-arylated DNA-conjugate. Out now in @J_A_C_S ! Open Access🔓 pubs.acs.org/doi/10.1021/ja…

@velang8 @karthick4347 @RamdassShridhar @SIVARAJc97 Congrats shridhar anna @RamdassShridhar and siva @SIVARAJc97

40th Annual Convocation @ VIT Vellore - 16Aug2025 3 PhD scholars graduated. Congratulations @karthick4347, @RamdassShridhar & @SIVARAJc97 !!! I wish you all the best for your future endeavors