Alina Ulezko Antonova

Excited to share one of my favorite PhD projects from @TheColonnaLab, now out in @ImmunityCP! Cross-tissue, age-spanning analysis reveals a PGD2-producing cluster and a cycling subset. Huge thanks to all collaborators, especially Dr. Eghtesady's team. cell.com/immunity/fullt…

What defines human pDC diversity? Our newest work led by @UlezkoAlina in @ImmunityCP uncovers a complex landscape shaped by age and tissue niche, including a cycling pDC subset that declines with age but persists in the BM & expands in malignant BPDCN. shorturl.at/99Zui

Check out our newest resource led by @jaeger_natalia and @UlezkoAlina describing the NK-ILC1 gradient in human tissues: rdcu.be/dM64F. The IEL contains true mature (PRDM1+) and immature (PRDM1-) EOMES-ILC1, while other tissues harbor ILC1-like NKs expressing ZNF683.

Highly variable ILC1 subtypes across human tissues: *abundant EOMES− PRDM1+ ILC1s in intestinal epithelium & few immature TCF7+PRDM1− ILC1s *widespread tissue-imprinted ZNF683+ EOMES+ NK cells @NatImmunol @TheColonnaLab @jaeger_natalia @UlezkoAlina nature.com/articles/s4159…

Our latest work reveals, through integrated transcriptomic and epigenomic analysis in human tissues, a novel cell type: RORγt+ DC-like (R-DC-like). Shoutout to first authors Alina and Silvia for their pivotal role in this collaboration with the Vermi Lab. pnas.org/doi/abs/10.107…