Untukx Kevin

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Untukx Kevin

Untukx Kevin

@UntukxK

Meneliti perilaku manusia di internet. Berita viral = bahan penelitian. Kadang lucu. Kadang tragis. Selalu menarik.

Katılım Ocak 2026
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Untukx Kevin
Untukx Kevin@UntukxK·
Kenangan paling berkesan apa yang kamu alami saat bermain Ask.fm? me : stalking crush waktu sma
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aii
aii@oeussia·
ketemu spesies cowo “sepakat” yang ga bener-bener sepakat dan hanya untuk membuat cewe diam di rl tu nguras energi bgt, klo emang gamau beradu argumen sekalian gausa ngomong aja, gausa ajak ngomong cewe juga, ga sopan ga ada adab
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George Ferman
George Ferman@Helios_Movement·
Study with 92 identical twins.
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George Ferman@Helios_Movement

Summertime = Hair growth maxing🦁 Why? Hair follicles have vitamin D receptors that are proven to help regulate the growth cycle. Now in case you have no clue what VDR and DBP are, give me 28 seconds to show you the basics. Let's start with vitamin D binding protein (DBP). DBP, also known as Gc-globulin (from “group-specific component”) is the primary carrier protein for vitamin D metabolites in the blood. It plays a central role not only in vitamin D transport but also in its bioavailability, activation and clearance. It’s a 58 kDa glycoprotein belonging to the albumin family (structurally related to albumin and alpha-fetoprotein) that’s produced mainly in the liver (also minor synthesis in other tissues like kidney and adipose) and its circulating concentration is quite high at ~4–8 μM. It binds multiple ligands with high affinity: -25(OH)D (calcidiol, the main circulating form): strongest affinity. -1,25(OH)₂D (calcitriol): lower affinity but still significant. -Vitamin D₂/D₃: weaker binding. -Actin (G-actin): a unique non-vitamin D role.DBP binds G-actin released during tissue injury or cell death → forms DBP-actin complexes → cleared by the liver. It basically prevents actin polymerization into harmful filaments that could obstruct microcirculation. This “actin clearance” role is critical in acute inflammation and tissue damage. Now DBP binds 85–90% of circulating 25(OH)D and 1,25(OH)₂D to prevent rapid clearance and protect them from degradation. The DBP-vitamin D complex has a long half-life of 2–3 weeks for 25(OH)D. Of course, only the free (unbound) fraction of 25(OH)D and 1,25(OH)₂D is biologically active and can enter cells to bind the vitamin D receptor (VDR). DBP acts as a reservoir, releasing vitamin D metabolites to target tissues whether that’s called kidney for activation by 1α-hydroxylase or immune cells for local immunomodulation. In the kidney for example, DBP-bound 25(OH)D is taken up via megalin and cubilin receptors (endocytosis), gets internalized and converted to 1,25(OH)₂D by CYP27B1. This is especially important in immune cells (macrophages, dendritic cells, T cells) that express CYP27B1 → produce local 1,25(OH)₂D for autocrine/paracrine immune regulation. Also, DBP itself has direct immunomodulatory effects and even modulates neutrophil and monocyte migration for example. If all these were too complicated, simply keep in mind that vitamin D3 metabolites, including 1,25(OH)2D3, are carried by serum vitamin D binding protein for now. Moving on to the vitamin D receptor. The Vitamin D Receptor (VDR) is a ligand-activated transcription factor that belongs to the steroid/thyroid hormone receptor superfamily. When bound to its active ligand (1,25-dihydroxyvitamin D / calcitriol), VDR directly regulates gene expression by binding to specific DNA sequences called vitamin D response elements (VDREs). This allows vitamin D to influence thousands of genes involved in things we discussed such as immune regulation, inflammation control, barrier function, cell growth, calcium homeostasis, and more. Now, in the inactive state (no ligand bound) VDR is primarily located in the cytoplasm, often associated with chaperone proteins that keep it stable and prevent premature activation. Upon ligand binding, VDR undergoes a conformational change, dissociates from chaperones, forms a heterodimer with the retinoid X receptor (RXR), translocates to the nucleus, and binds VDREs to regulate target genes. Some VDR is constitutively nuclear in certain cell types such as immune cells and keratinocytes. VDR is one of the most widely distributed nuclear receptors expressed in nearly every cell type in the human body. There’s particularly high expression in: Immune cells (the highest density is found here). Epithelial cells such as: -Intestinal epithelial cells (gut mucosa) -Keratinocytes (skin) -Alveolar epithelial cells (lung) -Renal tubular cells (kidney) -Bone cells -Neurons -Microglia -Muscle (skeletal and smooth) -Pancreas (beta cells) -Thyroid -Parathyroid -Adrenal glands -Adipose tissue -Liver -Cardiovascular endothelium And pretty much everywhere. So.......go and test your levels as a starting point. For more: fitandball.gumroad.com/l/bundlehelpds…

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YAPPINGFESS
YAPPINGFESS@yappingfess·
YAP! STOP!!! GW UDAH MUAK!! STOP! STOP! STOP!
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Wimar.X
Wimar.X@DefiWimar·
🚨 BREAKING 🇺🇸 TRUMP WILL MAKE AN URGENT ANNOUNCEMENT TODAY AT 4 PM ET! HE NEVER SPEAKS ON WEEKENDS UNLESS SOMETHING SERIOUS IS HAPPENING. THIS DOES NOT LOOK GOOD FOR MARKETS...
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Curious Minds
Curious Minds@CuriousMindsHub·
How To Learn Faster:
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BitcoinSapiens ⚡️
BitcoinSapiens ⚡️@BitcoinSapiens·
100 YEARS WE’VE BEEN WAITING FOR THIS YEAR 2026 IS A ONCE-IN-A-LIFETIME OPPORTUNITY
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BANG TANI
BANG TANI@petanirumah·
Kamu tahu nggak kalau ChatGPT sekarang bisa membaca garis tangan. Caranya dengan upload photo telapak tangan kamu ke ChatGPT kemudian masukin Prompt. Nah ini hasil garis tangan Bang Tani Yang mau Prompt cek di bawah ya
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Nicholas Fabiano, MD
Nicholas Fabiano, MD@NTFabiano·
Egg intake is associated with a lower risk of Alzheimer’s dementia.
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keritingrambut 𐂂
keritingrambut 𐂂@bgkiting·
Siapa yang baru sadar kalau: 1,2,3 Mei: Libur (Hari Buruh) 14 Mei: Libur (Waisak) 15 Mei: Libur (Cuti Bersama Waisak) 16,17 Mei: Libur (Sabtu & Minggu) 27 Mei: Libur (Hari Raya Idul Adha) 28,29 Mei: Libur (Cuti Idul Adha) 30,31 Mei: Libur (Sabtu & Minggu)
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Curious Minds
Curious Minds@CuriousMindsHub·
Write by hand. Write by hand. Write by hand. Write by hand. Because your brain learns better that way.
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プロ患者社長(ステIVがんサバイバー)
私のステージ4の癌を克服したレシピ ① 気合い ② 間欠的断食+ケトン食 ③ 運動(スクワット+腹筋) ④ サプリ(5-ALA) このレシピを友人に伝えると、同じく3ヶ月の抗がん剤治療でほぼ癌が無くなりました。 特に②は、病院から反対されるので、科学的エビデンスを探していましたが、最近断食もケトン食もたくさんエビデンスが出てきているようです。 ↓(ケトン食で母親の癌を治した専門家) youtu.be/KVXnVe8eOkM?si…
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Prabowo Subianto
Prabowo Subianto@prabowo·
14. Anggaran perjalanan dinas: Rp. 20 T per tahun. Ini pemborosan. Harus dicoret. Jika saya presiden, tidak boleh pejabat RI plesiran ke LN.
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Koezuma
Koezuma@Koezuma2·
@_auracabal Modal 15$ dan 1 minggu jadi segini. Alhamdulillah
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student
student@_auracabal·
Note, gua mulai uji coba bot polymarket start dari $7 (scroll aja postingan gua). Sekarang portofolio $35 berarti udah x5 ya? uji coba bot engga berhenti sampai disini aja, akan gua terusin sampai tanggal 22 April (Tepat sebulan dari pertamakali gua mulai uji coba bot dengan $7 aja). Apa hasil akhirnya akan bagus? sejauh ini udah 5x atau profit 400% sih. *disclaimer, -Gua engga jual bot, tapi gua akan dengan senang hati kirim bot nya ke kalian bagi yang udah support gua dengan donasi besar (dalam jumlah tertentu) sebagai tanda berterima kasih nya gua. -Gua cuma orang miskin/ orang susah (gua serius) -Gua bukan lulusan IT atau programmer. -Gua bukan penasihat keuangan. -Gua mau buktiin apakah orang luar yang pada ngebuild bot polymarket itu hanya marketing aja atau memang plot twist nya bisa di implementasikan. -Gua tidak sama sekali mempromosikan / mereferalkan polymarket. -Polymarket itu judi, ilegal (dibeberapa negara) dan highrisk.
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Untukx Kevin
Untukx Kevin@UntukxK·
@hoteliercrypto Bli semenjak kaya dan makmur bales dm kami yg ada di tweets, sedangkan dm balasannya lama 😭, jujur kangen sama bli dulu ketika masih jamannya laper dan followersnya dikit sering reply kami
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Hoteliercrypto
Hoteliercrypto@hoteliercrypto·
Total Subscriber saya ini 11.220 dari 99.032 follower 12% saja ga ada. Sisanya kemana ya? Padahal DM selalu dijawab kecuali endorse. Endorse Exchange, Endorse Koin, endorse P2P, Endorse berbayar pasti saya ga jawab. Kenapa kalian ga dm saya? Terimakasih sudah subs. *angka diatas hanyalah harapan belaka. 🤭
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Hoteliercrypto
Hoteliercrypto@hoteliercrypto·
Bagi yang punya usaha Money Changer mendekat lewat DM boleh, saya mau ketemu. 🤟🏻🤟🏻🤟🏻🤟🏻
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