VDG Lab @ EPFL

Our paper is now out! Cell damage regulates expression of lipid-modifying enzymes via alternative transcription. @SARSCoV2 exploits this to boost Spike #acylation #palmitoylation and generate more infectious #virions! @FS_Mesquita @AbramiLaurence nature.com/articles/s4146…

A fantastic collaborative effort! Congrats to all involved! @FS_Mesquita @AbramiLaurence @MaurineLinder10 @ShernazBamji @chembioBryan and Gisou van der Goot! @NatRevMCB

Late publicity! Check our last review regarding the wonderful world of S-#acylation aka #Palmitoylation. A comprehensive overview of the field and our take on the interplay between this #lipid #PTM and #immunity #metabolism #cancer and #brain. rdcu.be/dEk2w

Now Online Mechanisms and functions of protein S-acylation dlvr.it/T2l8H8

💡Viewpoint💡 💫S-acylation: an orchestrator of the life cycle & function of membrane proteins💫 ✍️By @FS_Mesquita, F. Gisou van der Goot et al from @EPFL_en ➡️buff.ly/3TJsBMF #deacylation #ERassociateddegradation #palmitoylation #proteinturnover #Sacylation #OpenAccess

Big thanks to all our collaborators and everyone from the @VDGLab @Trono_Lab @ACCESS_Unige. Learn more about the details of how cell damage caused by #viruses #toxins or #colitis regulates protein #acylation #palmitoylation, check it out!

Our paper is now out! Cell damage regulates expression of lipid-modifying enzymes via alternative transcription. @SARSCoV2 exploits this to boost Spike #acylation #palmitoylation and generate more infectious #virions! @FS_Mesquita @AbramiLaurence nature.com/articles/s4146…

Delighted to share our take on the only reversible lipid PTM--S-acylation as a major regulator of protein dynamics and function and its implications in health and disease in @JCellBiol . @gvdgoot Thanks so much. Proud! Highlights in thread (1/7) rupress.org/jcb/article/22…

Review: S-acylation is one of the most frequent posttranslational modifications that regulates diverse cellular processes. @MUmairanwar1 and @gvdgoot @EPFL_en discuss the complexity and disease implications of this highly regulated reversible lipidation. bit.ly/3ta9gsE

Finally, we show that #viruses produced by Long-ZDHHC20-expressing cells have enhanced infectivity. More details in the manuscript!

The N-terminal extension of ZDHHC20 prevents the protein from leaving the ER, extends its half-life, and enhances its #Spike modifying capacity by more than 35 times!

#SARS2 #Lipidation Chapter2. How #SARSCoV2 boosts Host #Palmitoylation to promote infectivity! #Infection shifts transcription of ZDHHC20 palmitoyltransferase to increase #Spike Palmitoylation and produce more infectious #virus Stay tuned for Chapter3 biorxiv.org/content/10.110…

Is there more than transcriptional programs to drive cell identity? Here with @GioeleLaManno we discuss the lipotype hypothesis nature.com/articles/s4158…

ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains cell.com/developmental-…

This was really a nice journey … thank you @MUmairanwar1 , @oxyquips and @AbramiLaurence for taking us this far…

Thanks to all involved, in particular @oxyquips @AbramiLaurence @gvdgoot @Gio_Dangel0. @VDGLab we have to celebrate. 2/2

How are membrane nanodomains formed? Delighted to share our preprint where we show that plasma membrane compartmentalization is controlled by rapid lipid composition remodeling at the ER-Golgi contact sites. (1/4) biorxiv.org/content/10.110…

Great team effort that characterizes the #viral #lipid composition and shows that host #lipidation is required for #SARS-CoV2 infectivity! @Gio_Dangel0 @matteodp @labriataphd @Trono_Lab @EnyaQing @FS_Mesquita @AbramiLaurence

Our work is out! We are happy to share how #Palmitoylation controls #SARSCoV2 (#Covid19) #membrane #Cholesterol organization, and promotes #infection cell.com/developmental-…