Min WU

this isn’t an abstract concept; your heartbeat is a stable limit cycle sciencedirect.com/science/articl…

An interesting phenomenon in dynamical systems is the limit cycle. A limit cycle is an isolated periodic trajectory, often taking form as a self-sustaining oscillation, where a system’s state follows a closed path and repeatedly returns to the same values.

@alec_helbling dynamical systems have so many more cool properties if you go from strict periodicity to allowing for things that are only kind of periodic en.wikipedia.org/wiki/Attractor

💥 🚀 New preprint! 🎉🥳 How do hundreds of organelles organize themselves into near-perfect patterns inside a cell, without a blueprint? We dive deep into how basal bodies (BBs) self-organize in MCCs - and how actin actively tunes their dynamics into order 🍪 🧵👇 (1/17)

Beautiful spatial pattern and scale-independent separation of organelles that eventually give rise to cilia 😍

~ memory is a flock of birds ~ i built a hopfield network and taught it the alphabet - then watched it remember in real time by adjusting the temperature. no neuron has the whole picture. the memory is distributed across every neuron’s connections.

AI has stimulated great interests in single-cell cognition and learning. Although AI often drew inspiration from neuroscience, there are only a few cases these models shed light back on biology cell.com/neuron/fulltex…

How can a single cell learn without a brain? We explore this in my new paper with @WallaceUcsf! We discovered that single cells may learn using molecules similar to those that animal brains use to learn, like CaMKII. Cells can also propagate memory states to their progeny! 🧵1/n

@silvirouskin Different NIH institutions were originally created for lobbying for more funding to basic research. Now it created the impossible task for explaining to the public that biology is not divided by these institutions. Talking about false premises.

Apparently my R01 is so interdisciplinary that no known branch of NIH is qualified to review it. I spend months writing it, and it was bounced off 3 different sections until it was WITHDRAWN. We are soon submitting this work to Science. Great support of innovative research. 💀

Very nice paper with a necessary discussion. Also Im glad to see microbiologists taking this step.

"This is not biology! You can't get this in biology!" Medicine laureate May-Britt Moser and artist Olafur Eliasson discuss the intersection of art and science at an event in 2015 at the Nobel Week Dialogue: The Future of Intelligence. Watch the discussion in full: bit.ly/4idW21N #WorldArtDay

We're in this week's Nature! We propose a model of how a cell learns by running an evolutionary algorithm: exploring different gene-regulatory combinations and using feedback responses to stabilize those combinations that reduce stress levels. Full text: nature.com/articles/s4158…

The second recommendation: “Focus on the Mission.” “In 2016, departing from its traditional emphasis on the creation and dissemination of knowledge, Yale expanded its mission statement to include ‘improving the world today,’ educating ‘aspiring leaders worldwide,’ and fostering ‘an ethical, interdependent, and diverse community.’ These are all worthy goals. But they are not what makes a university a university. “We recommend that Yale adopt a focused university-wide mission statement such as the one currently articulated in its own Faculty Handbook: ‘Yale University's mission is to create, disseminate, and preserve knowledge through research and teaching.’ This statement serves as the basis for the recommendations that follow in this report. At a moment when higher education is being buffeted from all sides, it is imperative to understand what we are here for and what universities do best. That requires clarity, not diffusion, of purpose.”

@odoreida @Qivshi1 Mutual inhibition becomes positive feedback

@Qivshi1 tbf i am talking about developmental rather than cell biology. one of these interactions is gonna have to DO SOMETHING!!!

Cell biology is a vast network of negative feedback, how could it not be constantly close to self organized criticality?

a super complex for proteolysis /lipid scrambling assembles like a spiral in its native membrane in e coli — dynamics freezing in time — amazing

Did you think that small gene regulatory networks are only capable of very simple dynamics? Guess again! Even very simple networks are capable of a rich dynamics. Check out our brand new review paper in Current Opinion in Systems Biology: sciencedirect.com/science/articl…

@YongdengZhang The microtubule images are amazing. Congrats!!

We introduce mirror-enhanced 4Pi-SMLM (me4Pi-SMLM), a streamlined single-objective configuration that leverages mirror-based retroreflection of the illumination beam to achieve near-isotropic localization precision of 2–3 nm, resolving diverse ultrastructural features.

@danieldamineli Maria’s talk was so inspiring! Pollen tube is an AMAZING dynamical system

@WUMIN_LAB Hopefully you will meet my long-term collaborator Maria Teresa Portes and our student Arthur Marcusse. I'm so glad to see you talk about Prigogine and Goldbeter, I am a huge fan of their work. Albert was in the last EMBL oscillator meeting I went, it was truly a blast!

Calcium oscillations are one of the most universal signals in biology. Yet we still know surprisingly little about how these periodic (or aperiodic) events arise. Happy to present our lab's latest work: doi.org/10.1098/rsob.2…

We were working on this the day before the first covid lockdown in Singapore. 😷

A decade in the making! Bringing together multiple generations across three countries and time zones. Easily the most meaningful and fun project I’ve ever worked on.