Cosmos Wang

My first work in Xiaowei's lab out as a preprint! I'm so honored to work with Shiwei and Pu @sclerei on revealing cell-type specific chromatin organizations in the motor cortex and contribute to the project by studying the effect of Mecp2 deletion. biorxiv.org/content/10.110…

Zhuang lab reunion at 4DN Annual Meeting

(7/7) Finally, we applied our technology to Mecp2+/- mice. We found that depletion of MeCP2 altered nuclear radial positioning and local A/B compartmentalization of chromatin loci in a radial-position-dependent manner in neurons, similar to its effect on gene transcription.

(6/7) Interestingly, we observed a correlation between nuclear radial positioning and the amount of bound MeCP2. Moreover, MeCP2 regulates gene expression in a radial-position-dependent manner and such effect is the strongest in excitatory neurons.

My first work in Xiaowei's lab out as a preprint! I'm so honored to work with Shiwei and Pu @sclerei on revealing cell-type specific chromatin organizations in the motor cortex and contribute to the project by studying the effect of Mecp2 deletion. biorxiv.org/content/10.110…

Thanks Pu @sclerei and Shiwei for teaching me MERFISH. And I'm also happy to make my own contribution to this project as well.

Charming video of Matt Meselson and Frank Stahl speaking about their 1958 experiment, which truly is the most beautiful experiment, and the beautiful friendship they have, and how playful and free science seemed to be back then youtube.com/watch?v=7-tnuA…

Thrilled to finally share my PhD work, out today as a preprint! 🎉 Q: How do the brain’s dopamine and serotonin systems work together to drive learning? 🧠 Short answer, 🧵 below Long answer: 1/9

@lumberjacob91 neurodegeneration

Have seen two stalled waymo driverless taxis in past two days, middle of the street blocking traffic both times. Never seen before, wonder what has changed?

A Hypothalamic Circuit Underlying the Dynamic Control of Social Homeostasis biorxiv.org/cgi/content/sh… #biorxiv_neursci

Work by @jhowardtrotter, @WangCosmos, @SudhofThomas & colleagues shows that a combinatorial code of neurexin-3 alternative splicing controls inhibitory synapses via a trans-synaptic dystroglycan signaling loop. nature.com/articles/s4146…

Excited to share our preprint from the Ginty lab @harvardmed and Sharma lab @Columbia. Big shoot-out to the co-authors (@MIskols and others whose twitter not known to me). We hope the DRG neuron genetic toolkit can be a useful resource for the field. biorxiv.org/content/10.110…

Thrilled to share our latest work from @JoeEcker lab, using cutting-edge snmC-seq3 and snm3C-seq technologies to generate 301,626 methylomes and 176,003 mC+3C multiome profiles from 117 dissected regions throughout the adult mouse brain. (1/n) biorxiv.org/content/10.110…

The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms biorxiv.org/cgi/content/sh… #bioRxiv

A molecularly defined and spatially resolved cell atlas of the whole mouse brain biorxiv.org/cgi/content/sh… #bioRxiv

Congratulations to Professor @CarolynBertozzi, winner of the 2022 @NobelPrize in Chemistry for her role in the development of bioorthogonal chemistry. stanford.io/3Tf1i9B