Jacob Blum retweetledi
Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming: nature.com/articles/s4159…
Philadelphia, PA 🇺🇸 English
Jacob Blum
221 posts
Jacob Blum
@lumberjacob91
Postdoc in the Gitler Lab @Stanford studying motor neurons and ALS. Former @Stanford PhD and @FulbrightIT scholar at La Sapienza in Rome.
Katılım Şubat 2013
171 Takip Edilen141 Takipçiler
Jacob Blum retweetledi
🚨What if we could reliably program macrophage polarization state?🚨
biorxiv.org/content/10.648…
Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)
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Jacob Blum retweetledi
Probably one of the handful of companies in the space of "virtual cells" that IMO has the right strategies, data modalities and models to really show the power of what happens when you deeply couple expt design, ML models to well thought out questions & applications.
Ron Alfa@Ronalfa
What if we could use a foundation model to simulate human biology from mouse data? Today, we're sharing Perturb-MARS, a platform for genetics and drug treatment in vivo at SCALE. ... and we HUMANIZE the read-outs using TARIO-2.
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Jacob Blum retweetledi
Welcome to the scientific revolution. 100s of robots. Zero coffee breaks. America’s largest autonomous lab, open today.
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@adamlewisgreen Beautiful, intuitive, yet contrarian work. Love it!
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The link to our cellular world model paper can be found in bio.
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In 2016, AbbVie acquired Stemcentrx for $5.8B, betting on their DLL3-targeting ADC for small cell lung cancer, Rova-T.
In 2018, the Phase III TAHOE trial was halted due to a higher death rate on Rova-T than on standard-of-care chemotherapy.
Our cellular world model—trained exclusively on RNA, and which has never seen a single drug—would have flagged this target before the first patient was dosed. Here's how:
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Jacob Blum retweetledi
A @Nature study from Rockefeller's @junyue_cao describes a new platform called PerturbFate that reveals how diverse genetic perturbations funnel into shared disease states, a method that could unlock therapeutic targets for complex diseases.
🔗: bit.ly/4thIsRw
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Jacob Blum retweetledi
Very excited to share the fruits of an epic collaboration with @MarkPlitt from @lisa_giocomo lab: doi.org/10.1016/j.neur…
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Jacob Blum retweetledi
A common question is whether non-genetic resistance mechanisms are “pan” resistant. Here’s the answer!
Cell Genomics@CellGenomics
Pre-existing cell states predict resistance to multiple treatments dlvr.it/TRn0Zw
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Jacob Blum retweetledi
@anshulkundaje articulates something the AI-for-biology practitioners (or AI-for-science for that matter) need to hear more: we are far from a stage that scale alone solves biology. Deep domain expertise and principled interpretation (as opposed to cherry-picking of results) is how we actually make progress. There's too much hubris right now in assuming one can brute-force their way through biological complexity without understanding it.
Anshul Kundaje@anshulkundaje
Great to see 2 fabulous papers using model interpretation methods developed in our lab for deep learning models of regulatory DNA being to reveal causal mechanistic role of sequence syntax mediated TF binding, methylation & histone variants in stem cell memory of inflammation 1/
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Jacob Blum retweetledi
The neuroscience of brain cancers: Neuron cell.com/neuron/fulltex…
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What a joy to be friends with such an exceptional scientist. Please read this elegant, simple, and groundbreaking article by @kevinguttenplan and the Freeman lab! It is worth your time.
science.org/doi/10.1126/sc…
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Jacob Blum retweetledi
Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS: nature.com/articles/s4146…
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Jacob Blum retweetledi
In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.
Check it out!
biorxiv.org/content/10.110…
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Steven is, and always has been, the real deal. Apply to his lab! Work with him!
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Jacob Blum retweetledi
A must see at @SfNtweets this year
@kaltschmidt_lab
Wu Tsai Neurosciences Institute@StanfordBrain
This morning at #SfN24: Wu Tsai Neurosciences Institute Faculty Scholar Julia Kaltschmidt (@kaltschmidt_lab @StanfordNsurg) shared recent insights on the development and organization of the enteric nervous system ("second brain") in rodents and humans.
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Jacob Blum retweetledi
AI x life sciences: Hype or hope or inevitability? Our firm (@LumaGroup_ like n follow!) take on this game-changing intersection, its impact, and VC's role in shaping the future. Read our whitepaper: lumagroup.com/wp-content/upl…
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Jacob Blum retweetledi
Let me make it easy for those interested in the truth or who have been denying that these mobs are motivated by anti-Semitism or support for terrorism. Here is a short thread with just some of the direct evidence. I will just focus on the protests at and around Columbia:
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Jacob Blum retweetledi
Very exciting to see brain organoid transplantation reach it's full potential - 1.) the dramatic TS-related dendritic phenotype is revealed only after transplantation 2.) transplantation offers a platform to test therapeutics in vivo within a human genomic context
Sergiu P. Pasca@Sergiu_P_Pasca
Today, I’m thrilled have our lab’s work featured on the cover of @Nature In this article, we have developed a therapeutic approach for a severe condition called Timothy syndrome. This has been a long journey. It started with making hiPS cell-derived neurons in 2D cultures 15 years ago when I was a postdoc and continued with later creating in the lab #organoid and then #assembloid models of this disease caused by a mutation in a calcium channel. Over time, these human cellular models and the biological insights we gained enable us to design a therapeutic strategy, which we validated in vivo following circuit integration of patient-derived organoids into the rat brain. Grateful for the incredible work led by @XiaoyuChenxy and @fikribirey in the lab! And the many close collaborators who participated to this line of research over the years.
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Bravo!
Sergiu P. Pasca@Sergiu_P_Pasca
Today, I’m thrilled have our lab’s work featured on the cover of @Nature In this article, we have developed a therapeutic approach for a severe condition called Timothy syndrome. This has been a long journey. It started with making hiPS cell-derived neurons in 2D cultures 15 years ago when I was a postdoc and continued with later creating in the lab #organoid and then #assembloid models of this disease caused by a mutation in a calcium channel. Over time, these human cellular models and the biological insights we gained enable us to design a therapeutic strategy, which we validated in vivo following circuit integration of patient-derived organoids into the rat brain. Grateful for the incredible work led by @XiaoyuChenxy and @fikribirey in the lab! And the many close collaborators who participated to this line of research over the years.
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