Wayne Ngo

I am so excited to share our new paper in @Nature: the first programmable, site-specific integration of a large DNA payload into T cells in vivo. A single IV injection results in therapeutic levels of TRAC-targeted CAR T cells in multiple models. #Ack1" target="_blank" rel="nofollow noopener">nature.com/articles/s4158… a 🧵

Amplified genome editing by in vivo editor production biorxiv.org/content/10.648… #biorxiv_bioeng

Targeted delivery of genome editors in vivo go.nature.com/4qKp6Tb

Excited to share our newest paper on @nchembio where we present temporal MultiMap for dynamic neighborhood mapping. Our sincere gratitude to all our collaborators @WayneNgo1 , Yu-Ting, @harrychembio , @katherine_susa for their hard work! nature.com/articles/s4158…

How do nanoparticles enter the tumour? In our latest study @NatureNano, we found tumour endothelial cells bring NPs in mostly using macropinocytosis & interestingly, macropinocytosis membrane ruffling is elevated in tumour vs healthy vessels 🧐@TheChanLab nature.com/articles/s4156…

🚨🚨New Paper🚨🚨 Ever wonder where EPR came from?👀 Matt et al. describe the history and evidence for the EPR effect and its impact on cancer nanomedicine. They also discuss a new theory termed the Active Transport and Retention (ATR) principle.🌶️🌶️🌶️ nature.com/articles/s4422…

🚨🚨🚨New paper🚨🚨🚨 @Matt___Nguyen et al. found that NPs exit solid tumours through the lymphatics in a size dependent mechanism, and proposed a new mechanism of NP delivery to tumours called the Active Transport and Retention (ATR) principle 🥵🌶️ tinyurl.com/4p7ymkjn

⁦@TheChanLab⁩ ‘s latest commentary - Principles of Nanoparticle Delivery to Solid Tumours | BME Frontiers spj.science.org/doi/10.34133/b…

@Labouta_Lab @TheChanLab @zacplin @DonnellyCentre @bme_uoft @uoftengineering @UofT Thanks Hagar!

@TheChanLab @zacplin @WayneNgo1 @DonnellyCentre @bme_uoft @uoftengineering @UofT Congratulations @WayneNgo1 ... Very interesting work!!

🔥🚨@zacplin and @WayneNgo1 here to post Chan Lab's first paper of 2023🔥🚨 We found that nanoparticles can pick up platelet factor 4 when they pass through injury sites. This enables nanoparticle binding to endothelial cells 🔎 (1) pubs.acs.org/doi/10.1021/ac…

@ShreySindhwani @TheChanLab 🎉🎉🎉 yeehaw!

@WayneNgo1 @TheChanLab 🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳

I defended my PhD (in person) yesterday!!! Thank you @TheChanLab for the wonderful 6 years!

@zclapacs @TheChanLab Thanks!

@WayneNgo1 @TheChanLab Congrats Wayne! Big moves!!

@StephAngers @DonnellyCentre @TheChanLab Thanks!

@DonnellyCentre @WayneNgo1 @TheChanLab Congrats Wayne !

Congratulations to @WayneNgo1 from @TheChanLab on a successful thesis defense! 👏👏👏

@Wilhelm_Lab @wilsonpoon Thanks Stefan!

@wilsonpoon @WayneNgo1 Congratulations Dr. @WayneNgo1 !

BIG BIG congratulations to my good friend, newly minted Dr. @WayneNgo1! So very proud of all your achievements! 👏🏻👏🏻👏🏻

@wilsonpoon Thank you for being a very good friend! ☺️

@wilsonpoon @TheChanLab 🤣

@TheChanLab Reposting one of my favorite nano memes 😅

🤩@WayneNgo1 & @jamielywu are here to share their paper, Identifying cell receptors for the nanoparticle protein corona using genome screens, in @nchembio! 📜:nature.com/articles/s4158… @DonnellyCentre @bme_uoft

Our PhD student @WayneNgo1 is at @KeystoneSymp this weekend - check out his poster and talk if you're there! 👋😎 #KSPrecisionGene22

ADDR in press: "Why nanoparticles prefer liver macrophage cell uptake in vivo" By Warren C.W. Chan & coworkers @bme_uoft @TheChanLab #nanoparticle #macrophages #MononuclearPhagocyteSystem doi.org/10.1016/j.addr…