Harry Wu

And therapeutically, is there an advantage to adding tall receptors versus the above? Also worth comparing with the approach of degrading the glycocalyx, as recently demonstrated by Bertozzi and Paszek labs.

Some thoughts: would simply increasing the affinity/density of the short immunoreceptors also confer a similar kinetic enhancement to that of adding tall receptors?

This is a cool addition to the size-dependent segregation model of immunoreceptor activation! Tall receptors, if at relatively low affinities/densities, can speed up short receptor binding at crowded cell-cell interfaces filled with bulky bystander proteins.

Now online! HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion dlvr.it/TPs7v4

Nature research paper: Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells go.nature.com/4rpIZ3b

Excited to share our newest paper on @nchembio where we present temporal MultiMap for dynamic neighborhood mapping. Our sincere gratitude to all our collaborators @WayneNgo1 , Yu-Ting, @harrychembio , @katherine_susa for their hard work! nature.com/articles/s4158…

@iskander Do you think the pneumonia/influenza vaccine comparisons were useful? And what are your thoughts on the mice model data? Would’ve been nice to have an additional control of LNPs without mRNA to parse out their relative adjuvant effects

A few different people reached out to see if I believe the results of "SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade" (nature.com/articles/s4158…) Answer? Kinda. I think the paper conflates three hard to distinguish effects:

Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors nature.com/articles/s4158…

So you want to change transgene expression: just change your promoter, right? Changing the promoter increases RNA and thus protein levels. What more could be happening? [1/n] Well, promoters don’t just set RNA levels; they uniquely transform how RNAs are transmitted into protein levels. 🧵

@Zhi_Lindsey_Lin @ScienceMagazine @realJimWells Congrats Lindsey! Excited to see a more accessible and probe-agnostic photocatalyst for proximity labeling

Thrilled to share our MultiMap paper is now published online on Science. @ScienceMagazine With @realJimWells, we present a multiscale photocatalytic proximity labeling platform for interactome profiling. science.org/doi/10.1126/sc…

Meet MagLOV: an engineered protein that responds STRONGLY to magnetic fields. This is a fluorescence timelapse of MagLOV in E. coli. We're waving a (small) magnet under the plate. Can you tell where the magnet is? Want some? It's on Addgene now! addgene.org/219957/

Why can RNA only be linear or circular? It can be branched! We made multi-tailed mRNA, and we had fun! Here is our story led by brilliant graduate student @HongyuChenChem: rdcu.be/dB7ck and his cartoon illustration👇@ChemistryMIT @broadinstitute

Structural evidence for a resting state of the T cell receptor in lipid bilayers. Are prior structures in detergent micelles activated? The resting state of the human T-cell receptor biorxiv.org/content/10.110…

What if small molecules could allow you to alter protein localization at will? What if they could allow you to turn on specific transcription factors? Our new manuscript reveals bifunctional molecules to do just that. 🧵

First year of grad school all done! Excited to pass the squeaker and juvenile phases and become pigs of the sounder! @doc_jlmeier @JeffsChemBio @harrychembio @DavidByunCCB @UCSF #chembio

Had a wonderful day at Chemical Biology in the Bay Area conference at Berkeley! Amazing talks from @davidrliu on gene editing and @CarolynBertozzi on bioorthogonal chemistry! Special thanks to great speakers and organizers @UCB_Chemistry!

Delivery of therapeutic molecules is a major bottleneck for treating a wide range of diseases. Today we describe a new modality for delivering proteins based on an engineered contractile injection system @nature nature.com/articles/s4158…

Scientific Fluency as the Greatest Strength of Chemical Biologists (Prescott, Huang) @PrescottNico @HsinCheHuang @TPCB_NYC onlinelibrary.wiley.com/doi/10.1002/cb…

I have been long-awaiting a TOC graphic as legendary as this.