Yimby George

@elonmusk @Cernovich Gurus who are affected by Trump, should recognise that they are merely facing the Angry grotesque Demon from the second temptation of Maara, once they touch grass. The Earth will bear witness to the impermanence of all, and they will be free from suffering.

@mrTeigen @i2cjak Can it look inside body? Emergency hand held scanner?

@i2cjak Things 10 minutes with AI takes you with these 24 GHz presence detectors. x.com/mrteigen/statu…

good thing this technology can only be used for things like uhhh respiration rate that’s it!!!

@robin_j_brooks I think the phrase you are looking for is "Andrew Bailey" blow up.

@TiffaniMarie483 @Hitchslap1 link.springer.com/article/10.100… 6 iq points gained with nicotine - Grok summary.

@Hitchslap1 I hold on to the hope that IQ can be raised through education or maybe gene therapy in the future. Whenever I come across people with obvious low IQs, it almost physically hurts to talk to them.

Most IQ deniers have never meaningfully interacted with an 85 IQ person. It’s nearly impossible to do so and still believe IQ is fake. Think about it.

Seems entirely possible Life on Earth was accidentally seeded by some super advanced nanobot weaponry from the Great Galactic War that made the night sky quiet. Probably a bunch of nascent civilizations about to encounter empty Ark ships and abandoned wormhole networks etc

@RokoMijic Will I lose state disability support and payments?

If you have a lifelong chronic illness that leaves you permanently bedbound or severely restricted, would you pay $100,000 for a cure, assuming it could be paid in installments ($9/day for the rest of your life)?

@mylandsinorder What is the symbolism of the banana?

Just walking back after lunch through my local park, and saw this. Pretty sure it was kids, rather than hardened Italian fascists, but still utterly disgusting behaviour (and yes I tried to break it before leaving but the sticks were too strong all tied together).

@RokoMijic Is there something like quorum sensing in game theory? If Restore makes a good showing, better than reform, even if they don't win - more voters and political operators will identify as restore in the next election.

I think the game theory here is that Restore should not stand. Restore mostly want Starmer to continue to be in charge of Labor. Why? Because he's a disaster. But to keep Keir, we need Andy Burnham to lose the by-election Reform Can beat Labor in the by-election If Restore also stand, it's likely to split the Reform vote.

@NikoMcCarty Now do pcp?

Complete biosynthesis of penicillin in tobacco plants. Every year, farmers in the US harvest about 840 billion pounds of corn. For comparison, there are only a few million liters of bioreactors, by volume, in the US. If we could engineer corn to make insulin at a titer of 1 g per kg of leaves (which is low; researchers previously engineered tobacco plants to express recombinant proteins at titers of 4-5g per kg), then we could make the global supply of insulin in an area of 1,230 acres; or roughly a square measuring 2.2 kilometers on each side. In other words, biomanufacturing with plants (or, recently, chicken eggs; see Neion Bio) feels highly underrated. There is a lot of “spare capacity,” and the farming industry has already built the infrastructure needed to scale! Alas, there are many things we cannot make with plants. Their chemical repertoire is fairly limiting when it comes to making human medicines. Many antibiotics, immunosuppressants, and antifungal medicines are made by enzymes that are missing from the plant kingdom. In particular, plants do not have non-ribosomal peptide synthetases, which are huge proteins that build peptides separately from the ribosome (hence their name). These proteins are used by fungi to make antibiotics, antifungals, and even many anticancer drugs (like bleomycin). For a new preprint, researchers in Texas engineered tobacco plants to make penicillin. They did this by engineering the plants to express seven fungal genes. This is not particularly impressive in terms of the size of the metabolic pathway (I recently wrote about tomato plants engineered to synthesize tobacco, for example, and that also required seven added genes and, arguably, way more work). The penicillin yield is also super low; just 25 micrograms per gram of dry weight, which is waaaayyyy lower than the titers were get from engineered yeast. But that’s not why this paper is important! It’s important because this is the first time that anyone has expressed a non-ribosomal peptide synthetase in a plant, so now we can engineer crops to make lots of other things, too. (The penicillin biosynthesis pathway, if you care, goes like this: The giant non-ribosomal peptide synthetase enzyme is in the cytosol. It grabs onto α-aminoadipate (a side-product when plants break down lysine), cysteine and valine. The enzyme snaps them all together, and also flips the valine from its normal "left-handed" shape to a "right-handed” one. A second enzyme, also in the cytosol, then pinches these amino acids together to make the β-lactam ring. Next, this molecule moves into the plant cells’ peroxisomes, where a third enzyme swaps the α-aminoadipate for a phenyl group, thus creating the active form of penicillin! The authors were worried that these chemical movements between the cytosol and peroxisome would not work by default, and might require engineering, but the proteins went to the appropriate compartments without any coaxing. That was a surprise.)

The pattern is correct. Somebody famous once said something very close to "To have good ideas, first have a lot of ideas." But "Be prepared to spend most of your career looking like an idiot" is an exaggeration. This can be avoided with a simple strategy of: don't blab about your big new ideas until you can deliver on them. Under-promise, then over-perform. I have failed many, many times. I will doubtless fail again. As a public figure, I have inevitably attracted some hatred. But my public failures have been few, and I don't have a reputation as an idiot even among the people who hate me. Because I manage my exposure! People don't know about most of my failures. What is true is that you have to not be afraid to fail privately. You have to not be fragile about this; learn from each failure, pick yourself up, and go back at it. And you have to accept the social risk of occasional public failure by not giving too much of a fuck about it. I think that's the hard part for most people, being so hung up on social validation that the fear of public failure paralyzes them. This is not quite the same thing as fear of looking like an idiot, though!

Turns out the microplastics moral panic was a scam

I think I posted this here a while ago but this is so insane to me

@HighyieldHarry Intc is still an opportunity.

What life would be like if you loaded up on semiconductor stocks in 2022

@esrtweet @justalexoki If magic is true then reality is a simulation.

@justalexoki What if the Earth is flat?

what if the Bible is true? what if it's actually true?

@sam_d_1995 @edavidds Farms convert solar energy with lower efficiency?

it’s so cool how these farmers are acting like they’re oppressed because people are voluntarily OFFERING TO PAY THEM MILLIONS OF DOLLARS

@ZahoorAhmed1450 @MedLearnHub It was used in the 1980s surely some progress must have happened since then? What is the underlying cause? Vascular malformations?

Absolutely right Dr ✅️ B) Carbamazepine is the first line treatment for trigeminal neuralgia. It works by blocking voltage gated sodium channels, thereby stabilizing hyperexcitable nerve membranes and reducing the characteristic sudden, lancinating facial pain. Your additional points are excellent especially regarding slow dose titration and monitoring for adverse effects like drowsiness, ataxia, hyponatremia, blood dyscrasias, and hepatotoxicity. The alternatives you mentioned (oxcarbazepine, gabapentin, pregabalin, baclofen, lamotrigine) are also clinically appropriate when carbamazepine is ineffective or poorly tolerated 👍

A patient with trigeminal neuralgia is treated with which drug? A) Valproate B) Carbamazepine C) Diazepam D) Lithium

@PHDcomics Claude can do it for you.

Need a plan

@RupertLowe10 The others in his party are worse. Call elections, but wait till restore has selected Candidates.

The very worst Prime Minister, of the very worst Government. Starmer has disgraced the office, and history will remember him as such. Resign.

@robkhenderson Suicidal empathy is not in the DSM... Can selection for that be measured? @gadsaad

"In genetic terms, it looks like Europeans have been selected for higher IQ, higher educational attainment, and less schizophrenia and bipolar disorder over the last 10,000 years. This is a startling result" thefp.com/p/humanity-is-…

@FCademartiri Cheapest hand held scanner that can make a difference in the field?

🩻⚠️ Radiology is not dying.
It’s becoming electricity. ✅ Invisible. ✅ Everywhere. ✅ Absolutely essential. And most people won’t notice until it fails. This paper makes a provocative argument: 👉 Radiology may stop being a “specialty.” Not because imaging matters less. But because it may become: the operating system of medicine. Honestly? That’s probably already happening. For decades, radiology worked like this: 👉 image acquired 👉 radiologist reads it 👉 report sent back 👉 everyone pretends the PDF is the actual product Classic. But modern medicine broke the old model. Now: - emergency physicians scan at bedside - intensivists use procedural imaging - cardiologists own advanced cardiac imaging - surgeons navigate in real time - AI pre-triages findings before humans even open the study Meanwhile radiologists are still arguing on LinkedIn about who owns ultrasound. The uncomfortable truth Imaging is no longer a location. It is becoming: infrastructure. - Like electricity. - Like Wi-Fi. - Like cloud computing. Nobody says: 👉 “The electricity department diagnosed my patient.” But try running a hospital without it. The paper’s strongest point Radiologists may evolve from: ❌ image interpreters to: 👉 system architects Meaning: - workflow orchestration - AI governance - quality control - imaging pathways - multimodal integration - diagnostic ecosystems Translation The future radiologist may spend less time: 👉 describing a 4 mm cyst And more time: 👉 designing how an entire healthcare system sees disease. And AI accelerates this dramatically Because once AI handles: - triage - segmentation - measurements - prioritization - preliminary pattern recognition …the bottleneck is no longer image interpretation. It becomes: 👉 integration 👉 accountability 👉 orchestration My provocative take Radiology spent years asking: 👉 “Will AI replace radiologists?” Wrong question. The real question is: 👉 “What happens when imaging belongs to everyone?” Because here’s the irony Radiology may become: ❌ less visible but ✅ more central than ever Final thought The most powerful technologies eventually disappear into the background. Nobody talks about: 👉 electricity 👉 TCP/IP 👉 oxygen in the OR They just become essential infrastructure. ⚡ Imaging may be heading there too. And if that happens: Radiology won’t vanish. It will become the invisible nervous system of medicine. #Radiology #AI #MedicalImaging #Healthcare #DigitalHealth #FutureOfMedicine #PhotonCounting #PrecisionMedicine