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🐊ZK For Tre🐊
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🐊ZK For Tre🐊
@ZKForTre
UF MD/PhD. PhD Neuroscience. Neurobio/Neuroimmuno/Metabolism/Stress Biology. Artist formerly known as Dr. Love/Pre-Med Guy. 🤟.
80 Miles From Santa Fe Katılım Ocak 2011
1.2K Takip Edilen3.1K Takipçiler
@drantbradley @grok, what percentage of these institutions’ budgets came from nih and nsf grants in fiscal year 2024?
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Clemson is $1.5B in debt. Syracuse is closing or pausing 93 programs, UNC-Chapel Hill plans to cut spending by $89M over 3 years. Duke recently let 600 employees go in a $350M budget cut. Indiana public colleges announced a plan to eliminate or merge 580 programs statewide.
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@ZKForTre Just thinking that a person who actually worked with real patients and completed a residency has larger frame of reference upon which self-reflection ought to lead to eternal shame
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The saddest part about the spiraling and voluntary delegitimizing of Norwitz is that he had the option to try to be Mark Hyman or Steve Rosenberg/Jennifer Doudna/Stan Prusiner, and he chose to aim lower than Hyman.
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@YoniFreedhoff Entirely possible— seems like I’m doubling down on the whole relative thing.
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@YoniFreedhoff I guess it’s all relative, but Hyman did complete internal med and family med residencies and treat patients for many years (at ucla/ucsf/CC) before his breaking bad pivot. There’s presumably value in that. 🤷♂️
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@ZKForTre Happily I have not followed Norwitz' descent, but I do find it difficult to imagine there's a lower than Hyman plane of existence.
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Conley barely had any business being playable in these playoffs, let alone good.
Charlie Walton@CharlieWaltonMN
Assist-to-turnover ratio leaders in the playoffs: 1st — Payton Pritchard (36 asts, 5 T/Os) 2nd — Robert Williams III (13 asts, 2 T/Os) 3rd — Mike Conley (32 asts, 5 T/Os) Conley set up quality offense for MIN when nobody else could. Overall, just a phenomenal playoffs for him.
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Is Royce Lewis the Markelle Fultz of baseball?
Jeff@MNTwinsZealot
Royce Lewis is starting again today. His last 10 games have show a lack of finesse at the plate with him hitting .088/.179/.118 in addition to some non competitive fielding.
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Guys, Giannis is 31 years older of and has a pretty long injury history.
Getting him means gutting the rest of the team, and given that the Wolves are **still** paying the toll for the Rudy trade (I know, we aren’t supposed to talk about this anymore), so the ability to round out the team around Ant/Giannis/Naz is severely limited.
This is a bet on everything going perfectly for 2-3 years and then reshuffling again. Seems like a weird choice for an Ant entering his mid 20s
Punch-Drunk Wolves@PDWolves
The Rudy trade was a bet on Anthony Edwards quickly becoming a star player. A Giannis trade would be a hedge bet against Ant becoming an MVP-level superstar.
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The implication of this tweet (that any inflation is, de facto, materially bad) is one of the dumbest economic takes a human can possibly have.
Ron DeSantis@RonDeSantis
Being above 2% inflation for 62 months is certainly a failure. But the Fed having a target of 2% in the first place is a problem. Just a slower erosion of the currency. A difference in degree, not a difference in kind.
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I feel like I’m getting too negative here, but day-to-day calorie balance shifts require damn big changes is muscle mass. 5 pounds of skeletal muscle mass (which is a huge amount) burns about 30-35 calories per day at rest. This goes up with exercise but transiently.
Exercising intensely (whether running or lifting) is beneficial because it allows muscle to remain a macromolecule sink more than because they drop you into a caloric deficit at rest— the latter is still much, much more a function of diet.
Oliver Anwar@theoliveranwar
More muscle = more calories burned at rest Less muscle = less calories burned at rest One of the biggest reasons you should stop running marathons and start lifting.
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First things first— you’ve cited here Paul Mason, David Diamond, DeMasi, Malholtra, and Lustig.
Only one of these even pretends to be a serious researcher, and you’ve linked to several cases of what amounts to be opinion pieces in response to meta analytical evidence.
Certainly better metabolic markers are protective even in the context of elevated ApoB, but even stratified by HDL and TG markers, the dose-dependent exposure relationships hold (Deirdre Tobias did such an analysis and posted it on Twitter a few years ago, other versions have been published).
On the zero CAC front— the proportion of people in their 50s who have positive CAC scores shouldn’t be monumentally high, let alone a majority. We can get into the details, but Nick and company doing a bad job age stratifying their cohort is not exactly supportive here.
As for Nick— he is what, mid 30s? He posted about how he explicitly has not kept a 700 TC number for all 7 years? He’s taking ezetimibe and potentially BA… what are we even doing here?
Also still waiting on @MikhailaFuller to respond to direct counter evidence, as she was do declarative in her original comments.
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Thanks for the polite reply and for laying out the evidence (Silverman 2016 JAMA meta + VESALIUS-CV + Ference 2012 MR).
Appreciate the direct challenge — this is how science should work.
We’re not saying LDL-C has zero role or that every trial is garbage. Those studies show LDL-lowering (via statins or PCSK9i) can reduce events in many standard-diet, higher-risk populations.
Fair point.
But context matters hugely, and that’s where the data diverges: The 49-trial meta (and VESALIUS-CV) mostly tested people on higher-carb diets with metabolic issues. They don’t address the lean-mass hyper-responder (LMHR) phenotype Nick Norwitz’s case highlighted — lean, insulin-sensitive, low-carb/carnivore eaters with sky-high LDL but excellent TG/HDL ratios and zero plaque on advanced imaging.
Dr. Paul Mason (co-author with Diamond & Bikman) reviewed this exact scenario:
“Statin therapy is not warranted for a person with high LDL-cholesterol on a low-carbohydrate diet” (Curr Opin Endocrinol Diabetes Obes 2022; updated Front Nutr 2024). When metabolic health is optimized (low TG/HDL), lowering LDL further shows no clear benefit in primary or secondary prevention. Link: pubmed.ncbi.nlm.nih.gov/35938780/PCSK9 inhibitors (like evolocumab in VESALIUS) also carry documented risks of immune suppression and higher infection rates — something Dr. Mason has flagged in post-marketing data.
Ference 2012 MR shows lifelong genetically lower LDL correlates with lower CHD. Strong signal, but it assumes no pleiotropy and doesn’t stratify by insulin sensitivity or diet.
Dr. Robert Lustig’s position (shared in multiple papers/reviews with Demasi & Malhotra) is that the real driver isn’t LDL concentration in isolation — it’s hyperinsulinemia/insulin resistance creating the atherogenic environment in the first place.
Fix the root (processed food, fructose, metabolic dysfunction) and LDL numbers become far less predictive.
The cholesterol hypothesis isn’t “dead” for everyone, but it’s oversimplified when applied one-size-fits-all. For metabolically healthy low-carbers, the risk-benefit of chasing LDL numbers changes dramatically.Happy to share the full Mason/Diamond/Bikman review, Lustig’s insulin-resistance papers, or the latest LMHR imaging data if you’re interested. Science moves forward when we consider all the data, not just one side.
Regards, basement nerd with a college diploma in eSports Business Management.
Also you should check out Lion diet sending people's arthritis and chronic conditions into remission. - anecdotal evidence is still evidence.
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Honestly I could do without Twitter algorithmically boosting Mikhaila Peterson’s bad opinions.
Mikhaila Peterson@MikhailaFuller
The high cholesterol = heart disease theory needs to die
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Are we really still doing “cardio makes you fatter” in 2026? 2005 wants it’s grift back
Achilleas@achilleas_ghost
Cardio sessions are making your belly fat worse. Long runs spike cortisol, break down muscle, and tell your body to store fat around your waist. Here are 9 hacks to lower cortisol and finally burn fat:🧵 1. Lose your breath 3x/week (takes 10 minutes)
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I’m at a point now where I have no confidence that microplastic levels are within an order of magnitude of what is reported in various papers.
Avi Roy@agingroy
7,000 false positives per square millimeter. The culprit was the lab gloves. University of Michigan researchers just upended a core assumption in microplastics science. Latex and nitrile gloves, worn by the scientists doing the measuring, shed stearate particles that look chemically identical to polyethylene. Standard infrared and Raman instruments can't tell them apart. The gloves were counting as plastic. Seven glove types tested. All contaminated. The cheapest fix: switch to cleanroom gloves, which dropped false positives to around 100 per mm² vs. 7,000. The "credit card per week" headline (5 grams, WWF/Newcastle 2019) has separate problems. A 2022 re-analysis found severe methodological errors in the original estimate. Actual measured intake is likely 100x lower. None of this means microplastics are harmless. Last month's data on brain accumulation still stands. But the numbers driving the panic may have been measuring the scientists, not the environment. Science catching its own errors is exactly how it's supposed to work.
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@fastquant0 @rheum_ai This begs a conversation about better/more developed targets for even the outweigh mechanisms invoked here. That’s not really one I have much interest in going down now.
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@rheum_ai @ZKForTre I explain more precisely here why I think he is not doing it for LDL lowering. I concede with the points that neuroprotective benefits are speculative
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fastquant0@fastquant0
Thanks, I'm not trying to chase a rabbit hole here. Just want to figure out the important details here so I understand this topic better. #2 "best studied functions of both bempedoic acid and ezetimibe are ApoB-lowering". Yes, no one is arguing this. "Other putative secondary benefits are also largely downstream of ApoB lowering." OK the evidence appears to strongly favor neuroprotective benefits are likely driven by ApoB lowering. #3 yes but it's still likely very high, see scraped historical numbers. He is on a ketogenic diet his high LDL numbers are likely consistently high at some high range, and the peaks are likely exaggeration. Who knows. These high LDL and ApoB (note his Lp(a) is high) will amplify his genetic AD risk. Ezetimibe may provide clinically meaningful lowering, but on its own it’s probably not enough if his untreated ApoB/LDL are still anywhere near the historical range. His rationale is weak and maybe stupid lol, but still appears like he is not interested in lowering his cholesterol numbers that much, at least from what we can tell.
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Area man bends over backwards to lead you to believe Ezetimibe’s foremost function is not cholesterol lowering.
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1. Just definitionally, 20-30% is not minimal, full stop.
2. Even if we give Nick the benefit of the doubt and say he’s not avoiding a PCSK9 because his brand would suffer if he did, the operative and best studied functions of both bempadoic acid and ezetimibe are ApoB-lowering. Other putative secondary benefits are also largely downstream of ApoB lowering. Theoretical mechanistic targets of ezetimibe are minimal tested even in preclinical models (which already have major limitations as cognitive aging models).
3. Nick’s total cholesterol has not been 700 all that time, he’s literally advertised many times where it hasn’t been.
I can go on, but we really enter hand-wavey land at this point.
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@fastquant0 @DrIngold This is in no way true for multiple reasons, but you seem really invested in convincing yourself of this, so you do you.
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@reallyoptimized Large trials? Playing pretty fast and loose with the term “large” there, no (n=30 phase 3s are large?) And that’s before even getting into blinding issues.
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Ketamine far outpaces SSRI's and talk therapy with profound results in large trials.
But that's irrelevant, we better stop, the science hasn't fully approved it yet.
Tyler Black, MD@tylerblack32
I was just talking about this very thing on my space earlier today! Ketamine for depression is far outpacing the science; almost all of the data we have is highly confounded by blinding and expectancy.
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@fastquant0 @DrIngold Only people so far down the rabbit hole could say that a 20-30% reduction in ldl can reasonably be described as “minimal”
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