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🐊ZK For Tre🐊
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🐊ZK For Tre🐊
@ZKForTre
UF MD/PhD. PhD Neuroscience. Neurobio/Neuroimmuno/Metabolism/Stress Biology. Artist formerly known as Dr. Love/Pre-Med Guy. 🤟.
80 Miles From Santa Fe Katılım Ocak 2011
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@sircalebhammer It’s almost like you should read what you’re replying to so you don’t look like a moron.
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Whatttt the thing that has happened every time happen again whattttt
New York Post@nypost
NY sees dramatic exodus of US millionaires - causing nearly $11B loss in tax revenue: study trib.al/XRS6Ndj
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And I appreciate this sentiment. What I am trying to inject back into the discourse (for all my snark and glibness and Debbie Downerism at times) is humility in extrapolating or presenting as fact single studies or small bodies of literature with huge variance.
Sometimes one or a couple of papers can be definitive and revolutionary. Those don’t tend to be the ones that get extrapolated on by scicomm influencers (both good and bad).
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No, it didn’t come across that way.
I think the issue is guys like Max and myself are trying to do the right thing by sharing studies to combat the sci-nonsense being shared by grifters
But reading (and understanding) research is a skill. Been doing it for years and still not great at it because my time is spent working directly with clients and running my biz
So maybe help us do a better job understanding the context, study design, or results we missed
Well, at least I’m open to it
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It’s interesting how many of the health-fluencers have run with this study as gospel despite its obvious flaws, starting with the fact that the reported effect is like swinging from 1.5 SDs above average intelligence to 1.5 SDs below standard intelligence— an effect size that is entirely and completely absurd and should lead you to question anyone who would present it as an honest estimate.
And yet, it’s a parade of the influencer sphere. I almost hope it’s more that they didn’t even read the study— reading it and still going with it is almost worse.
Max Lugavere@maxlugavere
Just telling people they slept poorly led to impaired cognitive function. Telling them they slept fine preserved it.
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That’s fair, and I’m not suggesting here that @maxlugavere was trying to profit here or anything like that (sorry if it came across that way).
I’m even fine saying that I should have put up a big, flashing divider between grifters selling stuff (Brecka, Mercola, etc) and people who are doing scicomm (whether it be well or poorly). I don’t think my original response suggests a valence either way, but I understand things get interpreted in such a way on the internet.
What I will stand by is the need for better epistemic standards on these types of psych/social/behavioral neuroscience papers. How much more evidence to we need of poor design, over-extrapolation, and zero reproducibility in these fields to realize that when the effect size is preposterous and not even consistent within the study, all kinds of red flags need to go up and need to be mentioned in the tweet promotion of some giant social effect.
Clearly this is not a priority given the number of health influencers (note, not even the outright grifters) that jumped all over it.
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@ZKForTre I hear you. But understanding the details of how research is conducted is difficult.
Not to mention the reproducibility crisis with a lot of papers
I think you’re right to add missing context but Max was genuinely trying to help here and has nothing to gain from sharing this
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@Earthshine34 That would be true of several areas of medicine if we went to MfA tomorrow. Maybe that tradeoff is worth it (it probably is), but getting the American consumer ready for that is a huge lift.
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@ZKForTre I have to wait over a month to get orthotics with Health Partners.
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Short commentary on the concept of Medicare for All in this decade (and the failure of politicians and journalists who interview them to wrestle with what it means):
For those proposing it, I want to see white papers on how you are going to stand up the federal infrastructure to manage all of healthcare in this country within 5 years. You can’t pass a bill under President Ossoff (hopefully) in 2029 and say it’s going to be implemented in 2040. You don’t have assurances that the investments can sustain that many administrations’ whims.
Most notably, how are you going to get large providers on board? Are you going to pay Medicare reimbursement rates for all of healthcare? How are you going to prepare the upper half of the income distribution for the changes that will force on their healthcare access? The idea that they will still enjoy their same-week orthopedic appointments is a fantasy. If you allow exceptions, how are you going to make up the funding gaps of the richest Americans paying for swanky private policies?
We have nowhere near the infrastructure to manage this level of bureaucracy at this point, and the notion of standing it up while you pass the legislation is beyond absurd. So where are the white papers?
Dr. Abdul El-Sayed@AbdulElSayed
Money out of politics. Money in your pocket. Medicare for All.
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This touches on a core truth about the state of AD clinical science as it stands today:
We have a ways to go yet on establishing all the precise mechanisms, but being healthy in middle age is protective against AD later in life. We can be very confident in this at this point.
This is juxtaposed next to the equally accurate statement that our drug candidates are probably being introduced too late, that their effect sizes once MCI is present are relatively small, and we should be looking for drugs that can shield or protect cognitive function in the dementia context alongside disease-modifying AD therapies going forward.
Midlife health + cheap screening + early intervention options for high risk people in their 40s + late stage rescue drugs in the AD playbook. Unfortunately this is social, financially, and scientifically hard.
Steve Magness@stevemagness
A study found a 60% reduction in Alzheimer's risk for people who did at least 4 of the following: -150+ min of exercise -Didn't smoke -Didn't drink heavily -Ate a Mediterranean-style diet -Regularly engaged in cognitively stimulating activities (reading, playing games, etc.)
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@JoseAntonioPhD I think we should view this as a good development with slow social awareness. Up until relatively recently, the women being understudied (and female sex in preclinical research) was absolutely a real thing.
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"Each year, females made up about 55-60% of participants in NIH-funded trials." So much for the oft-repeated fabrication of "women are understudied."
James L. Nuzzo, PhD@JamesLNuzzo
Sex of Participants in NIH-Funded Trials Here is another source confirming data that I have published previously at The Nuzzo Letter. These graphs were published in a 2015 report written by the U.S. Government Accountability Office. The graphs show the sex composition of participants in NIH-funded clinical research between 2005 and 2014. Each year, females made up about 55-60% of participants in NIH-funded trials.
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If you think the health influencersphere is reduced only to sponcon, I don’t really even know what to tell you— we don’t even live in the same universe.
I’d argue this rebuttal is categorically less relevant than any engagement with the data quality here, but this only reinforces my point 🤷♂️.
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@ZKForTre What would be the incentive for influencers? If anything influencers that shill sleep trackers would not want this shared, no?
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Imagine being so lost in the culture war that it prevents you from enjoying what is reportedly one of the great movies of the last few years.
Defiant L’s@DefiantLs
Sage Steele on The Odyssey: I do think the Elliot Page thing is comical.. First of all, she's a she. I'll call you Elliot, but you're still a woman. And a 5'1 female doesn't exactly define a warrior to me.
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@caloriesproper2 Dude I regularly work until 10 or later. I’ll eat when I damn well please.
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Some old school bro-science that might have actual value: no food after sunset
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I saw a graduate student claiming a 4.33 **undergrad** GPA today.
When did we start doing that, and is nothing sacred anymore?
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Reminder: this is based on some truly utopian assumptions.
Rep. Mark Pocan@RepMarkPocan
REMINDER: Medicare for All would save 68,000 lives and $450 billion a year.
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I can’t believe people are taking this premise at face value.
Eric Topol@EricTopol
An inflection point in medicine. Medicine is moving from calendars to clocks — from counting the years you've lived to measuring how fast you're aging. —It's not linear. —It's asynchronous, as seen by organs and cells in our body A "translation" of our review paper this week in the new Ground Truths Simplified image made with ChatGPT
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🐊ZK For Tre🐊 retweetledi
Seeing Gad Saad get treated like a real scholar in the Wall Street Journal is dark. What are we doing here? Are there any standards at all?
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🐊ZK For Tre🐊 retweetledi
Crazy thing is, we did this entirely by getting good at treating /other diseases/.
Richard Hanania@RichardHanania
We’re winning the war on dementia. In the 1980s, 30% of 85-89 year olds had dementia. Now it’s 10%.
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NIH director describes mega top-down control of scientific funding (less reliance on peer-review and more focus on the strong arm or the partisan actors at the top), and the first comment is complaining about COVID vaccines.
1. I don’t think I have to tell anyone that political oversight or funding decisions is a disastrous idea.
2. Why are antivax blatherings (from some random/bit) still getting boosted to the top of the pile? @elonmusk
Sign of our times.
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