Leiping Zeng

Is SLR effective against the VOCs? SLR injection 4 hours post exposure with P.1, B.1.526, B.1.351 or B.1.1.7 led to significant protection from disease & death. Difference in effectiveness might reflect the IFN-resistance of these variants. biorxiv.org/content/10.110… (8/)

@VirusesImmunity What is SLR?

Latest preprint by @tianyangmao et al shows that a stem-loop RNA RIG-I agonist in mice can 1) Block viral replication and disease when given early after SARS-CoV-2 infection (including VOCs) 2)Eliminate chronic infection in immunodeficient mice 🧵(1/) biorxiv.org/content/10.110…

My 14 yr daughter just made this beautiful illustration for our study on CD36 in CD8 T cells. authors.elsevier.com/a/1dCK33qNrUmR… If you need any artwork for your papers or slides, let me know. She would love to do more!

This is an example of an interactive correlation heatmap by InteractiveComplexHeatmap. Clicking on each cell on heatmap draws a scatterplot of the two corresponding variables. See the live version as well as source code at jokergoooo.shinyapps.io/test_htShiny/.

Article has been retracted but @SpringerNature still charges $40 bucks to read it, without any sign it is retracted. Even worst, Springer charges ANOTHER $40 to read the "Withdrawal" notice. That is a shame. link.springer.com/article/10.138…

Super exciting new study showing SARS-CoV-2 recruits a haem metabolite to evade antibodies to the N-terminal domain of Spike – all started from a curious observation: colour change in purified protein... medrxiv.org/content/10.110…

In the latest issue! Targeting FBXO44 promotes #antiviral #signaling, decreases #tumorigenesis and overcomes resistance to #immune checkpoint blockade bit.ly/396hPby @UCSDMedSchool

Our preprint is now live: biorxiv.org/content/10.110… We can explain Paul Sigler's 1988 "Acid blobs and negative noodles" nature.com/articles/33321… Acidity and disorder keep the hydrophobic motifs exposed so they bind coactivators.

Please check our new paper-Skeletal muscle antagonizes antiviral CD8 T cell exhaustion advances.sciencemag.org/content/6/24/e…

A guide to #Cancer_ImmunoTherapy | Mechanisms of T cell activation and regulation | Michael Lenardo @NIAIDNews @NatRevImmunol buff.ly/3cTfGzn

Review detailing all we know about the effects of #COVID19 on immune health, as well as the steps we're taking to fight it. Research from @SinaiImmunol Find it here, publishing out of @ImmunityCP : bit.ly/2WKFPuz

@jengreitz Wonderful work!

I am excited to share our latest work, in which we tackle the question: How can we predict which enhancers regulate which genes in which cell types? nature.com/articles/s4158… Thread 👇 1/