Aniruddha Das

After an enormous effort, finally out! Our biochemical, computational, proteomic, and lipidomic data unravel the regulatory mechanism of CHIP processivity and reveal its role in lipid metabolism. #proteostasis #ubiquitinligase #metabolism doi.org/10.15252/embj.…

Farming arose on multiple continents among populations with radically different cultures and environments and with no means of communicating with each other – how did it crop up independently at about the same time? #Echobox=1741716888-4" target="_blank" rel="nofollow noopener">newscientist.com/article/247154…

Biologists are discovering a world of beings tinier than viruses that appear to be everywhere – even living inside us. We have no idea what most of them are doing, but they raise profound questions about what life is and how it got started. #Echobox=1739833503" target="_blank" rel="nofollow noopener">newscientist.com/article/mg2653…

Join the lab if you're passionate about ubiquitin research and enjoy collaborating with a supportive team, working closely with a PI who personally takes interest in developing the project.

Microplastics have been found just about everywhere scientists have looked. Now scientists are trying to determine their effects on your health go.nature.com/4hT9cS6

Science is under threat.

1/ Excited to share the first preprint from my PhD work co-authored with @alessandrick on how UFMylation and the ribosome-associated quality control (RQC) pathways collaborate to clear stalled ribosomes at the ER! #UFMylation #qualitycontrol #ER biorxiv.org/content/10.110… 🧵(1/8)

Check out our latest review on Regulation of physiological and pathological condensates by molecular chaperones at @FASEBPubs. Thanks to @AkareeNadeen for spearheading, and it was also fun to work with Serena Carra! febs.onlinelibrary.wiley.com/doi/10.1111/fe…

We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵 @LeopoldParts, Pierre Murat

New paper just dropped on @nchembio 🥳 A powerful platform for the rapid discovery of cyclic peptide inhibitors of protein aggregation!!! This is a nice collab with Prof. Tina Wang lab at @UWMadisonChem and congrats to Jingwei @zhjiww 🥳 nature.com/articles/s4158…

Super excited to finally share our new manuscript, out today in @NatureCellBio! This is the culmination of 6 years of work examining a seemingly simple question: What are the metabolic requirements for overcoming mitochondrial stress? nature.com/articles/s4155…

Our new study: science.org/doi/10.1126/sc…. It provides useful tools for studying LLOME lysosomal damage. Plasmids will be available soon on @Addgene.

Elegant use of dTAG to characterize the immediate consequences of ZFN143 loss on transcriptional targets.

Molecular mechanisms underlying p62-dependent secretion of the Alzheimer-associated ubiquitin variant, UBB+1 biorxiv.org/cgi/content/sh… #biorxiv_cellbio

"Scientific breakthroughs do not happen in isolation; progress depends on the collective contributions of many. This prize celebrates the work of large communities of scientists over many years." - chemistry laureate David Baker in his Nobel Prize banquet speech. Read his full speech here: nobelprize.org/prizes/chemist…

If you're thinking about going on the faculty job market, take a look at this advice doc I just shared with helpimascientist.com: I collected my thoughts about the whole dang thing, from finding positions to negotiating a contract, & I hope y'all find it helpful!

Phosphorylation of α-synuclein fibrils at S129 changes DNAJB1 binding as probed by solid-state NMR biorxiv.org/content/10.110…

We are thrilled to share our new preprint around oncoprotein degradation in vivo —a fantastic collaboration with our friends in Salamanca @lab_santamaria @ciccancer! 😃 @IRBBarcelona #TPD #KRAS 👇 biorxiv.org/content/10.110…

Excited to share our latest preprint on @biorxivpreprint: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro". biorxiv.org/content/10.110…

🎉 Researchers from IIMCB, led by @wojtek_pokrzywa , have been honored by the @PAN_akademia for groundbreaking discoveries in proteostasis mechanisms 🌟👏 👉Read more: tinyurl.com/PASaward

Excited to report our discovery of an important component of the oxidative stress response, the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress. biorxiv.org/content/10.110…