HÆDRON

@bryan_johnson @HiddenBullStock Weren't you previously on Epithalon? There's very little evidence supporting it besides the Khavinson studies. (Though personally I found it helped me calibrate my sleep cycles and sleep onset)

@HiddenBullStock The combination is not supported by any published data. Peptides live and breath on anecdotal claims like yours, it is useless without the data.

People mistakenly believe peptides are only good. Peptides can be bad, too. They can cause adverse effects. Some dangerous. I did a peptide experiment and measured its effects in my body. The results are complicated. I tried a peptide called CJC-1295. It pushed my growth hormone up by ~8x. That’s good. That’s what it was supposed to do. But, it also came with adverse effects: > increased my morning fasted blood sugar up 20% > increased stress hormone by 12% > tanked my REM sleep by 23% > made my pancreas work 53% harder and was still losing to rising blood glucose > increased my insulin resistance by 50% These were the most obvious side effects, and I only ran a very narrow panel for this experiment. So I’m sure there’s more. I stopped after two doses, without even reaching the intended target dose. For those of you new to peptides, your body sends instructions to itself using tiny chemical messengers called peptides. There are thousands of them. For example, GLP-1s are drugs that take an existing class of short-lived peptides and modify them to extend their activity duration, which turns them into drugs, following rigorous clinical testing. CJC-1295 is one of those peptide-drugs. It tells your brain to release more growth hormone. Growth hormone is your body's signal to build muscle, repair tissue, and recover. However, and like most grey market peptides, CJC-1295 did not succeed its clinical trial, and hence never became an “official” drug. There is a version called CJC-1295 with DAC. DAC is an attachment glued onto the peptide that makes it last for days in your body instead of hours. One shot, longer effect, just like GLP-1s. Why people use it: more growth hormone could mean better recovery, leaner body, faster healing. The experiment I completed. Two injections a week of CJC-1295 with DAC: > 1.2 mg > 1.8 mg 48 hours after the first injection I was nearly comatose. It felt like severe jet lag, the type you’d feel after traveling nine time zones. My sleep was wrecked and I felt continuously awful. My REM sleep dropped by 23%. REM is when your brain processes memories and repairs itself. Less time for my brain to repair itself. During the experiment, I never felt rested and always fatigued. Why we chose CJC-1295 with DAC. Some will say we picked the wrong peptide. They will say I should have used a different version, CJC-1295 without DAC, mixed with another peptide called Ipamorelin. We went with CJC-1295 with DAC instead as it has the most controlled studies. CJC-1295 with DAC has 2 controlled trials in healthy adults. Ipamorelin alone has 1 controlled trial in healthy adults, plus 1 study that failed when they tried it on bowel surgery patients. The mix of the two has zero controlled trials. On Ipamorelin, it copies a chemical called ghrelin, the one that makes you hungry. On its own it gives you a quick burst of growth hormone that fades fast. It does not keep your longer acting growth signal (called IGF-1) up. Clinics mix Ipamorelin with CJC-1295 no-DAC because the two together are supposed to work better. But we don’t know if that’s accurate because we don’t have trial data. This is a problem with peptides. Almost none of them have been tested properly. We are flying blind. Most of what people use is based on what someone said online, what a clinic claims, or what a friend reports from their subjective feelings. Peptides have the potential to be great when well-studied.

BPC-157 fixed injuries that doctors called permanent. Severed nerves — REGREW. Torn ligaments — REBUILT. Destroyed gut lining — REVERSED. A punctured cornea — HEALED. Parkinson’s tremors — GONE. Not in years. In WEEKS. → regrew SEVERED nerves → reattached tendons to BONE → 90% knee pain relief in HUMANS → reversed gut damage from Advil → healed a PUNCTURED eye → reversed Parkinson’s and prevented DEATH → no lethal dose EVER found A 15-amino-acid peptide from your own stomach juice. Your body makes it. Just not enough to finish the job. That shoulder. That knee. That gut. Every injury you still carry is a repair your body started and never completed. 500+ published studies. Your doctor has never mentioned it. BPC-157 finishes what your body quit on. I take Barrier Health’s oral tablet BPC-157 personally. No injection. No prescription. Code ALFRED saves you 15%. I’ll drop the link below.

@prestonjbyrne You're a good man for offering help pro bono. Here is a boilerplate response you may find helpful.

Verus lost $11.58M dollars just now on a bridge they said had no code to exploit… Their homepage still reads: "No Code to Exploit - Currency, DeFi, identity and data operations are blockchain primitives. Validated by protocol rules, not custom code." That was their entire pitch No smart contracts No audits needed No attack surface One transaction proved how wrong that is sadly Here’s what happened: Details still being confirmed but an attacker called an unknown method on the bridge contract Internal transfers fired and by the time the block confirmed, $11.58M was drained 1,625 ETH 103 tBTC 147,658 USDC Tornado Cash funded the attacker's wallet 13 hours before the exploit so this wasn’t a fluke $11.4M currently sits in the drainer wallet converted to ETH via Uniswap And there has been no statement from the @VerusCoin team yet The craziest part of it all: Two days ago the team pushed v1.2.14-2 emergency update "Urgent, critical, mandatory” were the words they used They found something, supposedly patched it, and then they told the community it was closed The attacker's wallet was funded 11 hours after that announcement 🤨 Kelp DAO lost $292M through a "novel" messaging layer Nomad lost $190M on a "trustless" design Wormhole lost $320M with institutional backing Each one had a specific argument for why the old attack playbook didn't apply Verus had a cleaner argument than most The $11.58M is gone and the “unhackable bridge" claim in DeFi is certainly dead

It’s happening…

WordPress now runs fully onchain on the Internet Computer ($ICP) Frontend, admin, database, no AWS, no Cloudflare. A solo dev shipped it in 7 months. @miadey The path for WordPress builders who care about hosting is now viable 💪♾☁️

@kayicp Very cool! I remember interacting with IC dapps for the first time and freaking out because my balance wasn't showing up, I was so used to how EVM networks handled assets 😭

i've been building ii-powered apps on $ICP for a while & the principal fragmentation problem still drives me nuts every new ii app = new principal. no shared funds. no shared identity. no way to build on top of each other. so i built the fix 🧵

@FrankieDimes @VersanAljarrah @dominic_w My thoughts exactly, I was roasting him on his youtube vid- such an insular take.

Edo & @VersanAljarrah - I’ve followed both your work for years, and when it comes to how DLTs will transform global payments, you’re spot on However, putting $ICP in the D tier is egregious $ICP is the future of cloud computing. Please watch @dominic_w cloud engines demo ☁️

@HealthyAlfred Any chance of international shipping coming any time soon?

I get 50+ DMs a day asking where I get mine. PLEASE check this before you DM me. Barrier Health — enteric-coated tablets, pharmaceutical-grade, third-party tested. Code ALFRED for 15% off. They sell out. Don’t wait. barrier.co/?ref=ALFRED

Scientists DESTROYED rat livers with 90 days of non-stop ALCOHOL. Every marker was failing. BPC-157 REVERSED the damage — key markers back to NORMAL. While they were still drinking. (PMID: 11595456 — foundational study, confirmed across multiple models since) If you drink and pretend your liver is fine: → Bloated after 2 beers → Foggy mornings even after “just a few” → Bloodshot tired eyes every morning → Fatigue that coffee stopped fixing → Pain under your right rib you keep ignoring Ignore it long enough and the scar tissue wins. That’s called cirrhosis. It doesn’t reverse on its own. Alcohol replaces working liver with scar tissue. Every drink makes the scar thicker. Milk thistle doesn’t reverse this. NAC doesn’t. “Taking a break” slows it but doesn’t rebuild what’s destroyed. BPC-157 reversed fatty liver, restored cell size to normal, and fixed portal pressure — in rats still being exposed to daily alcohol. This isn’t a free pass to keep poisoning yourself. It’s a repair signal for people ready to rebuild. ↓

@TutaPrivacy Scumbag move, yes but a 4gb local model isn't going boil the oceans the same way a 10+ trillion parameter model will if queried on a daily basis.

Google Chrome silently installs a 4 GB Gemini Nano AI model on your device. ❌ No consent ❌ No opt-in ❌ No real opt-out for regular users This isn’t a small experiment & it’s on billions of devices. ➡️ Read more: thatprivacyguy.com/blog/chrome-si… 😠 A tactic we've already seen with Gemini on Android. But at least you can disable it here, learn how: tuta.com/blog/how-to-di…

NHS HAS A STEP-BY-STEP GUIDE FOR DESTROYING WHISTLEBLOWERS. THEY JUST NEVER WROTE IT DOWN. UNTIL NOW. Peter Gooderham was an academic lawyer and former doctor. He spent most of his working life trying to understand why @NHS staff who raised patient safety concerns kept ending up bankrupt, mentally broken, or both. Before he died in 2011, he sat down with Private Eye (@PrivateEyeNews) and documented the playbook in full. It goes like this. First, cut their secretarial support. Block their merit awards. Briefing against them informally. Tell colleagues they have attitude problems and can't move on. None of this is illegal. All of it is deliberate. Then dig up dirt. Real or invented. Allege mental illness. The stress of the process makes this self-fulfilling, which is convenient. Refuse to disclose documents. Claim it's a local employment matter. The Department of Health will back this up because they always do. Then apply to the Treasury for public money to pay them off and shut them up. Some gagging agreements require the whistleblower to sign statements saying all their concerns have been addressed. Even when they haven't. Even when people are still dying. If they refuse the money, send the lawyers. Threaten libel. Throw public funds at employment tribunals, where NHS trusts are seasoned professionals and the whistleblower is walking in alone. If the trust loses, appeal. Keep appealing until the whistleblower runs out of money. The public purse is unlimited. Their savings are not. And if none of that works, don't worry. Public inquiries are, in Gooderham's own words, belated exercises in grief management that seldom change anything. By the time one arrives, the people responsible have moved on and the problems are dismissed as historical. The Gooderham playbook was not a historical curiosity. A @Channel4 investigation found gagging clauses in 55 of 64 NHS compromise agreements sampled. Over 40 NHS organisations refused to provide information on how many they had signed. One trust wanted over £10,000 just to produce the information. Another argued you couldn't even publish their reasons for refusing. This is a system that was designed, iteratively, over decades, to neutralise whistleblowers. The public funds the mechanism. The mechanism silences the people trying to protect the public. And then a public inquiry happens 15 years later and describes the culture as disappointing. Source: Private Eye (@PrivateEyeNews) Shoot the Messenger, Dr Phil Hammond (@drphilhammond) and Andrew Bousfield

The U.S. federal government has a ghost. His name was Aaron Swartz. At 14 he co-wrote the code that powers every podcast on Earth. At 19 his startup merged into Reddit. At 24 he was a Harvard fellow studying corruption. In 2011 he downloaded 4.8 million academic papers from JSTOR. JSTOR declined to press charges. The federal government did not decline. 13 felony counts. 35 years in prison. $1 million fine. For downloading research. His lawyer warned the prosecutor he was a suicide risk. The prosecutor's response, on the record: "Fine, we'll lock him up." While he waited for trial, he built one last piece of software with two others. A way for any whistleblower in the world to reach any journalist in the world without dying for it. January 11, 2013. Aaron died by suicide in his Brooklyn apartment. He was 26. His father said at the funeral: "Aaron was killed by the government." A Marine named James Dolan kept the code alive. Iraq War veteran. PTSD. He installed it at The New York Times, The Washington Post, The Guardian, The Intercept, ProPublica. December 2017. James died by suicide in a Brooklyn hotel. He was 36. Two of the three creators are dead. Here's the wildest part: The repo's first commit is dated January 11, 2012. Aaron died exactly one year later. To the day. The code is still alive. Last push: today. 3,804 stars. 706 forks. AGPL-3.0. Audited by Bruce Schneier. Used by 65+ newsrooms across the world. Two dead developers vs. the most powerful government in history. But DO NOT use SecureDrop. We should all let the government keep its secrets. 100% Open Source. (Link in the comments)

2 in 3 people silently bled in their gut after JUST 14 DAYS of NSAIDs ONE PEPTIDE reversed it in 3 days. bloating? brain fog? fatigue that won’t quit? joints still aching even with daily ibuprofen? NSAIDs are tearing the lining of your small intestine right now — and they’re: – ripping holes in your gut wall – pumping bacterial endotoxin into your bloodstream – feeding the inflammation the drug is supposed to stop you don’t feel it. your doctor doesn’t test for it. (Maiden 2005, PMID: 15887101) in 1997, a Croatian team gave rats aspirin, indomethacin, and diclofenac. their guts tore apart. then ONE peptide stopped the damage cold. same study, three drugs. (Sikiric, PMID: 9403784) in a 2011 follow-up, the same peptide reversed gastrointestinal, liver, AND brain damage from diclofenac — within the 3-day dosing window. (Ilic, PMID: 21295044) BPC-157. BPC-157 upregulates ZO-1 — the structural protein that builds tight junctions. the wall reseals. endotoxin stops crossing. the fire goes out. if you’ve taken NSAIDs more than weekly for the last three years, your gut wall has accumulated damage you cannot feel. Phase I human safety trial cleared. almost 30 years in the literature. there’s no patent on a 15-amino-acid peptide. so almost no doctor knows. which means your bloating finally calms down, your brain fog clears, and the damage you couldn’t feel finally stops. you aren’t broken you’re leaking. the full protocol (dose, timing, etc) — pinned.

Just remember, in 2021, June 21 Matt Hancock stated that we were going to be the biggest organ donors in the world… Yes little old 🇬🇧! Did you forget to opt out? You’ve all been opted in and are automatically organ donors unless you opt out. Remember, you cannot take an organ from a cadaver, from a dead body. You are very much alive and they prioritise your organs. You are paralysed but often Awake ! You just don’t live to tell the story. You do however move but they try to tell you these are just spinal reflexes. Total nonsense … take a read and then opt out. This is the stuff of horror movies and many have refused to participate after witnessing this. organdonation.nhs.uk/register-your-…

@limitlesstack I got all of those taking noopept, unfortunately I misjudged how much of a profound stimulant it was and ended up perma-fucking my sleep. Still has given me insane memory recall though years later but my resting heart rate was like 110bpm for like a week straight.

people say life is brighter on meth but have you tried coluracetam? the most visually aesthetic nootropic i've come across - enhanced color saturation and contrast perception - better pattern recognition and spatial depth perception - shapes and edges more defined - retinal and optic nerve repair via increased ChAT activity - increased optical vividness. "HD vision" effect reported it does this by acting on cholinergic pathways which regulate vision, memory, learning, and arousal which means it also has a ton of cognitive enhancing benefits beyond just perception. - faster information processing and learning speed - better reading comprehension - improved working memory at all tested doses - improved abstract reasoning and pattern recognition - enhanced thought connectivity - increased attention span and alertness see the world the way artists see it. without the psychedelics or the schizophrenia. not medical advice.

Palantir run!!!!!

@Pirat_Nation The data breach is the intended point. A world in which everyone has been doxxed is functionally identical to a world with mandatory digital ID. Your every post can be shown to your boss and your bank to punish you for your speech.

Since we're talking about network downtime and @IOHK_Charles is in the thread I believe ADA has had higher uptime than bitcoin, which has stalled twice: one time to reverse an inflation bug in 2013 and another to patch an exploit found by a bitcoin cash developer which was introduced by core in 2016 IIRC. At present, bitcoin has the best Lindy, Metcaffe effect and liquidity depth but it doesn't defacto make it a winner else it's market dominance in the space would be 100% not 65. Bitcoin has higher friction on L2s because of reasons aforementioned and friction on the base layer as a payments tool due to the inherent unpredictability of transaction fees in cases where refunds need to be processed (the reason why steam and newegg no longer accept bitcoin as payment). The reason why altcoins exist is because there are market niches in compute, storage, privacy and governance that bitcoin by design cannot fulfil in a decentralized manner. Having a plurality of different approaches and consensus mechanisms leads to more decentralization, not less.

@_Haedron @IOHK_Charles The market overwhelmingly doesn’t care about decentralization or privacy. The market chooses a protocol that has the most trust, as well as lowest downtime, and which has low friction to build on due to simplicity in design and not being feature rich.

Red Lines x.com/i/broadcasts/1…

@99boosterjabs @IOHK_Charles UDP lives on top of IP in parallel with TCP. TCP has significantly more robust error detection than UDP and wouldn't support UDP's throughput if it were built on top of it. They're both distinct protocols built on top of the IP layer. @grok feel free to fact check.

@_Haedron @IOHK_Charles We aren’t talking about higher level layers like HTTP or Gopher, though. Those are not an apt comparison. The truth is that protocols are winner-take-all. UDP ultimately lives ontop of TCPIP. Bitcoin is TCPIP in this comparison. There’s just no weaseling out of it.

Higher layers always come with drawbacks, the closer the features are implemented to the consensus layer the more decentralized they are: it's easier to create a feature that interfaces with AI/privacy/DEFI on the L1 than it is to do so with several layers of abstraction on a L2 which introduces the possibility for re-entrancy/ timing attacks/ side channel exploits. People who are strong proponents of the bitcoin only philosophy don't realize the irony of how centralized some of their offerings are, liquid for instance requires 11/15 multisig with no witness or signature rotation yet I don't see any criticisms levelled at blockstream. Lightning has its own problems, the developers admitted on page 55 of their whitepaper that it would take 133MB blocks to have the network scale to global adoption (which is verboten to purists). That's before mentioning the cycling attacks, the need to prefund accounts in order to spend your funds, the need for non-custodial lightning network users to rebalance channels periodically. All of these frictions cause user migration to more centralized providers like wallet of Satoshi (app). ARK is probably better than LN, though VTXO's expire so isn't ideal for long term holding. Users are made to perform clinical UTXO management between accounts/ not friendly for onboarding new users. Threshold ECDSA with chain key is a far more elegant solution because (bitcoin) private keys don't exist in isolation and can be bound to the private key of another chain and sharded between trusted execution environments which can be dovetailed with 2FA to spend. You can transact (native, not wrapped) BTC at the consensus speed of the secondary chain. It'd take a consensus failure on the secondary chain, an exploit seldom seen in the industry (most hacks are bridge exploits/ oracle manipulation / flash loan attacks or re-entrancy based) and the malicious party wouldn't be able to reconstruct your bitcoin key to steal it because it doesn't exist in plaintext. But never mind that a bunch of Google and IBM pedigree developers worked on it, it's shit because it's not advertised as a bitcoin only solution right?

@_Haedron @IOHK_Charles Every flashy feature that Shitcoins do at the expense of decentralization or security will occur on higher layers built on Bitcoin. Fedimint, ARK, Lightning, etc and of course many more to come. Those all do what Shitcoins innovates a decade ago. They’re now obsolete