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I’m excited to share our significantly-updated preprint on de novo antibody design, where we now demonstrate the structurally accurate design of scFvs (in addition to VHHs) with RFdiffusion! biorxiv.org/content/10.110…
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Joseph Watson
129 posts
Joseph Watson
@_JosephWatson
Co-Founder @ Xaira Therapeutics Former Baker Lab PostDoc at @UWproteindesign. Interested in generative modelling for molecular design. Views my own.
Katılım Eylül 2020
95 Takip Edilen3K Takipçiler
Finally, for the past year or so, some of us have been working to build the next generation of these tools at Xaira Therapeutics (@Xaira_Thera), with the aim of fully realising the promise of therapeutics design. If you’re interested in being a part of it, do get in touch!
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In particular, thank you to the other lead authors, @naterbennett0, @RobertRagotte, @AndrewJBorst, @dejsee, Connor Weidle, @wanderingriti and Yutong Yu! And thanks as always to David Baker for the leadership and for creating such a vibrant and exciting scientific environment!
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I’m excited to share our significantly-updated preprint on de novo antibody design, where we now demonstrate the structurally accurate design of scFvs (in addition to VHHs) with RFdiffusion! biorxiv.org/content/10.110…
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All the big things happening to all the best Davids!
Congratulations David 😍
David Juergens@DaveJuergens
⚛️ I got a new job ⚛️ After 5 wonderful years at @UWproteindesign and @UWMolES, I’m headed to Palo Alto for a postdoc at @StanfordUChem under Todd Martinez. SUPER excited to dive into deep learning for quantum chemistry and explore the Bay Area!!
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Congratulations to all - incredibly deserved! It was a total and constant honour working with David. His passion for protein design and its applications, as well as his uncanny attention to detail continue to inspire me. And nothing we do today would be possible without AlphaFold
The Nobel Prize@NobelPrize
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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Very exciting to see this work out! It still feels quite amazing that you can take three functional bits of protein and bring them all together with novel scaffolds, all while retaining their native function. Congratulations to @karla_mcastro for leading this super cool project!
Bruno Correia@befcorreia
protein design is getting weird ... and increasingly functional ! These are very weird designs ! biorxiv.org/content/10.110… fun collaboration with @karla_mcastro @_JosephWatson @jueseph @UWproteindesign
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A great day for science!
Congratulations to the teams at @GoogleDeepMind @IsomorphicLabs!!
Google DeepMind@GoogleDeepMind
Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬 Here’s how we built it with @IsomorphicLabs and what it means for biology. 🧵 dpmd.ai/3URDiNo
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Joseph Watson retweetledi
I am pleased to share that I have accepted a position @Stanford to start as an assistant professor in the department of statistics, with an affiliation in @StanfordData, this fall!
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@MathieuEmile @CalSleeper @FlightFreeUK I 100% agree! The sleeper is so great, and incredibly convenient, but since the upgrade it's just way too expensive to get a bed. Shared rooms would still be much more comfortable than the seats!
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@CalSleeper @FlightFreeUK Many nights are fully booked, eg bank holidays weekend, so this would increase capacity without having to change anything! It would also allow more people who currently cannot afford the full cabin price, to be able to travel with the magical experience that the @CalSleeper is 🤩
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Joseph Watson retweetledi
@CalSleeper really love travelling on your sleeper trains! Why not allow for booking 1 berth in cabins whilst keeping the option to book the full cabin? Would increase the number of people who could travel by train instead of flying! Feels quite a waste of berths atm 🤷♂️
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We're extremely grateful and excited to have the backing to try and realise this vision! I'm very excited to work with our growing team of amazing people in the UK and US.
Read more about the project here:
endpts.com/in-biggest-eve…
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I'm excited to announce that I'm part of the team at Xaira Therapeutics!
This project has been some time in the making. I'm convinced that generative modelling, and ML for biology more generally, will play a pivotal role in the next generation of therapeutics. 1/2
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