
Waasay H. Khan
44.1K posts

Waasay H. Khan
@__oldwine
PGY-2 #residencyandchill #POCUS | weightlifter & a wanna be chef 👨🍳 🩺 🫀 #aspiringcardiologist 🇵🇰🇺🇸


As a doctor practicing medicine in the USA for a quarter of a century, I appreciate your thoughtful perspective and commitment to lifestyle changes—lifestyle is indeed foundational for metabolic health, and many patients achieve meaningful improvements in lipid profiles and blood sugar through disciplined diet, exercise, and weight management. That said, robust clinical evidence from large randomized trials and meta-analyses shows that when LDL cholesterol remains elevated despite optimal lifestyle efforts (or in higher-risk individuals), statins significantly reduce cardiovascular events and death. They lower LDL-C effectively and cut major adverse events by 20-30% per 1 mmol/L reduction, including reductions in cardiovascular mortality (often 15-25% relative risk reduction in high-risk groups) and all-cause mortality in many settings. For those needing even more aggressive LDL lowering (e.g., familial hypercholesterolemia or very high residual risk), PCSK9 inhibitors (added to statins) further drop LDL-C by 50-60% and reduce key events like heart attack, stroke, and revascularization by 15-27%, with emerging data showing benefits in cardiovascular death reduction in certain trials. Guidelines prioritize lifestyle first, but evidence-based medications like these are not “masking” symptoms—they target the causal driver (elevated LDL) to prevent plaque progression and events, often saving lives when lifestyle alone isn’t sufficient. Always personalize under medical guidance. Keep up the great work on health!







Over the past month, we (@AdamMeier20, @JTLonsdale) have been working on a state bill that would permit AI to practice medicine - prescribing, diagnosing, referring, and ordering - with some oversight and guard rails. We want the technology community to be able to solve important problems for society, and there are few matters bigger than access and cost of healthcare. We have sought feedback from different groups, but are eager to hear from more builders: does this let you harness AI for the biggest impact on the US healthcare system? We are eager to hear from states as well: what healthcare problems and patient populations are most in need? Done right, this bill should be a win for patients, taxpayers, physicians, and governments. AI should benefit ordinary Americans. Tell us what we got right, what we got wrong, and where we should go from here. We will still need federal clarity on clinical AI, but states will be important stakeholders in any regulatory regime. Reimbursement will be a topic for future discussion too.




When humans conversationally present medical scenarios to #AI chatbots, the accuracy of diagnoses is < 35% sciencenews.org/article/medica… Original article in Nature Medicine nature.com/articles/s4159…






🚨 SAM ALTMAN: “People talk about how much energy it takes to train an AI model … But it also takes a lot of energy to train a human. It takes like 20 years of life and all of the food you eat during that time before you get smart.”

Somewhere, an ID doc just sighed. (Yes, this is real).

Your future doctor is using ChatGPT to pass med school so you better start eating healthy






@DutchRojas It’s fun and exciting for Elon to say Optimus is coming for surgeons and AI will replace cognitive specialties in the blink of an eye…but if even if that’s 1/10th true…we should be able to vaporize the healthcare administrative complex in seconds…


