basilp

@DrCamRx Of course eating right is important, but a lot of disease is a calorie excess and the effectiveness of GLP-1s at treating variety of other metabolic symptoms is a testament to that.

Unpopular Opinion: I'm the biggest advocate of GLP-1s, but I think they're used wrong. They're originally diabetes drugs, their magic is in reversing insulin resistance, yet they're overused for crushing appetite (hell, smoking does that). You still need to learn to eat right…

@edzitron He said this in November 2025.. businessinsider.com/michael-burry-…

Oh hey look it’s exactly what I said back in December 2025 wheresyoured.at/nvidia-isnt-en…

@MyScottbivens66 @elonmusk It is.

@elonmusk Reuters just told me it was jubilant supporters.

Problems in Paris

@KatieMiller so you clearly don't know how LLMs work..

ChatGPT says Charlie Kirk wasn’t assassinated.

@alexisohanian @shaunmmaguire Not about fluency at all. The reason the Dems don’t like AI, is because they don’t like the tech bros and especially their support of Trump.

@shaunmmaguire Agree and I'm absolutely spending more time in DC around this issue. And I agree that Dems are way behind - we can't afford to have only one party be fluent in the issue and why it's so important USA wins.

To everyone in tech AI policy should be one of your top issues And on this issue, the Republicans are vastly better than the Democrats

@parmita @JTLonsdale @precigenetic guy's a fucking loser in my view.

I have no ability to actually block someone as accomplished as @JTLonsdale I don’t plan on it I find it sad that he didn’t engage with a single point of mine seriously and that we are fighting about “estimations” instead of trying to understand what @precigenetic already built

@MartinShkreli @infinite_victim @jamestalarico wow.. simping for Paxton... texastribune.org/2026/05/19/ken… no shame.

@infinite_victim @jamestalarico yes and it is

#AhmaudArbery is the latest American killed by the virus of racism. The virus kills our black neighbors if they’re jogging, playing music, sitting in church, selling CDs, or carrying a bag of Skittles...

@RechterAV @iMiaSanMia Olise pretending to understand French.

@iMiaSanMia Olise obviously doesn’t find that extremely funny.

Marcus Thuram imitating Michael Olise in France training 🇫🇷

@NMowbray23 think about a number you just made up?

85% of the left in NZ have never worked in the private sector. Think about that.....

@thsottiaux @giordanorandone @OpenAI Frustrating little goblins those bugs.

@giordanorandone @OpenAI Nah. The only thing that caught us off guard was a bug we discovered last minute. And we decided to not ship the said bug.

I am relatively sure that @OpenAI was caught off guard by Anthropic today and postponed the release unexpectedly. I cannot really explain it any other way, given how damn quiet it was, even though every Codex Thursday usually comes with announcements, even if they are only small ones. Today, there were a few small updates mentioned on the website, but they were not even properly announced on X. And when you also consider that there was vagueposting by OpenAI staff just yesterday, everything points in that direction for me. Are you guys disappointed, or do you think it is better this way?

@RealColinHudson @NASASpaceflight lol not to politicize? What does the left even have to do with this.

@NASASpaceflight Not to politicize this but ever far left wing loony tune whose been ripping SpaceX because they don’t like Elon’s politics can sit the fuck down.

Blue Origin's New Glenn just blew up at LC-36 while attempting to Static Fire ahead of NG-4. nsf.live/spacecoast

@agingroy @ArtemyShumskiy Why is there not an accelerated path for patients still dying from these cancers. 6 years is a long time.

@ArtemyShumskiy It is. But that BioNTech pancreatic data gives hope. 7 of 8 vaccine responders alive at 6 years, in a cancer that kills 87% within five. We're watching the first real proof that neoantigen vaccines can hold for years, not months.

Five cancers that used to be death sentences. Pancreatic. Glioblastoma. Triple-negative breast. Renal. Melanoma. The median survival for metastatic pancreatic cancer is still 6 months. Glioblastoma, 15 months. Now personalized mRNA vaccines are producing complete remissions in some of these patients. Not responses. Remissions. BioNTech’s pancreatic cancer vaccine has 6-year follow-up data. 8 of 16 patients who mounted an immune response are still alive. For a cancer that kills 95% of patients within 5 years, that's incredible. Topol’s pyramid here maps the trajectory. From broad checkpoint inhibitors at the base to personalized neoantigen vaccines at the peak. The technology is climbing.

@Austen (And Google owns about 15% of Anthropic)

Kind of crazy for Anthropic to be approaching $1 Trillion valuations when all of Google (including search, cloud, Android and by the way Gemini), is pulling in $425 Billion in annual revenue and is only worth $4.7 Trillion

@AWar1586398 @dwlz Even if you’re eventually right about a bubble in the long term you can get wrecked by shorting against it. Since no one knows when a bubble will pop.

@AWar1586398 @dwlz As anyone with a clue knows the market can stay irrational much longer than u can stay solvent.

AI is massively overhyped. There's no way these valuations prove out. Problem is that I have no idea how to position myself. Equities have run up so quickly that volatility premium is insane. You can't short this stuff unless you're willing to go bankrupt. What is the move?

@_PXLWorld_ @dwlz Even if it’s useful what happens if DeepSeek/(random open source model) catches up in 2 years and has token prices 1/10th or 1/100th of Anthropic/OpenAI how do they survive that?

@dwlz How can you think it’s over hyped then , you must see the value ?

@MartinShkreli @agtrader Vague-posting nonsense is off-brand for you.

@agtrader im sure if you were closer to the situation it would make a little more sense for you. but you focus on other things and other circles, thankfully.

Im sure the Saudi's are reading your tweet and laughing after giving Kushner 2 Billion dollars based on his superior investing ability alone

@PJanL7 @MattWolfgang @bennetthaselton @pmarca A couple, polite of you to ask.

@_basilp @MattWolfgang @bennetthaselton @pmarca Yeah. How many boosters did you have?

@pmarca A bit on the nose, yes, but shouldn’t one be more concerned about what the actual President does and says, rather than a rando audiobook writer? Trump called Somali immigrants “garbage” among about 10 million other things.

@MartinShkreli @richriker Our own eyes and ears confirm it nearly every day.

@richriker and who do you know, first hand, that can confirm this?

You are an idiot if you believe this. This second term is all about lining his pockets. And revenge. He can be bought for a dime.

@ihtesham2005 Sounds to me like she needs to test if it’s just standing and not the walking. Tons of anecdotal evidence of ideas coming through while just standing in the shower.

A Stanford psychologist spent 4 years proving that the simple act of walking generates 60% more creative ideas than sitting, and the experiment she designed to kill every alternative explanation is one of the most decisive findings in modern psychology. Her name is Marily Oppezzo. She got the idea for the study while walking with her advisor at Stanford to discuss her thesis topic, and the paper she eventually published in the Journal of Experimental Psychology in 2014 is sharp enough that it should have ended the seated meeting on the day it came out. She ran 4 experiments on 176 people. Same person tested twice. Once sitting, once walking. The creativity tasks were the standard ones psychologists have used for decades to measure how good a brain is at generating novel useful ideas. The result was almost too clean to publish. 81% of participants in the first experiment produced more creative ideas while walking than while sitting. In the second experiment, 88%. In the third, 100%. Every single person walked into a more creative version of themselves. On average, people generated 60% more novel useful ideas the moment their legs started moving. The skeptical question is the obvious one. Maybe it was the fresh air. Maybe it was the scenery passing by. Maybe it was the change of environment doing the work, not the walking itself. Oppezzo killed every one of those explanations with one experimental decision. She put people on a treadmill facing a blank wall. No scenery. No fresh air. No environmental change. Just legs moving in place while staring at white drywall. The 60% boost held. Then she ran the experiment that closed the case completely. She took participants outside in two conditions. Half of them walked through a Stanford courtyard. The other half were pushed through the exact same courtyard in a wheelchair. Same outdoor stimulation. Same scenery passing at the same speed. The only difference was whether the legs were moving. The walkers produced dramatically more novel high-quality ideas than the wheelchair group. The outdoors did almost nothing on its own. The walking did everything. This is the part of the study that hit hardest when I read it the first time. She also tested the opposite kind of thinking. Convergent thinking. The kind where there is one right answer and you have to narrow down to it. Word puzzles where 3 words share a hidden fourth word that connects them. The seated participants did slightly better on these. Walkers got slightly worse. Walking is not a general intelligence enhancer. It does one specific thing. It opens up the divergent search inside your brain. The part that generates options. The part that produces unexpected connections. The part that takes a problem and finds five ways into it instead of one. When you need to converge on the single right answer, sit down. When you need to find the answer in the first place, get up. The mechanism is now well understood. Walking selectively activates what neuroscientists call the default mode network, the system inside your brain that runs when you are not consciously focused on anything. The DMN is where mind-wandering happens. Where memories cross-reference each other. Where ideas that have been sitting in separate folders inside your head finally bump into each other. When you sit at a desk and force yourself to concentrate, you suppress the DMN. When you walk at a natural pace, the executive part of your brain gets just busy enough handling the walking that the DMN comes online and starts doing the work that focus was blocking. The most useful finding in the entire paper is the one almost nobody quotes. The boost did not turn off the moment people stopped walking. Participants who walked first and then sat back down stayed elevated. Their next round of seated creativity work was still significantly better than people who had been sitting the whole time. The rest lingered for at least several minutes after the legs stopped moving. You do not need to do creative work while walking. You need to walk before the creative work. The brain holds the state. The history of this is the part that should haunt anyone who still does meetings in chairs. Charles Darwin built a gravel loop behind his house in Kent called the Sandwalk and walked it 3 times a day for the rest of his life. The theory of evolution was developed one lap at a time on that path. Nietzsche walked up to 10 hours a day during the years he wrote his most important books and openly said the work was conceived on his feet. Beethoven composed for the morning and walked for 5 hours every afternoon with a pencil in his pocket for when something landed. Kahneman said the best thinking of his Nobel Prize-winning career happened on leisurely walks with Amos Tversky. Steve Jobs refused to take important conversations sitting down. He held them on foot. Every one of them was using the system Oppezzo would not measure until 2014. They just did not know what to call it. The question worth sitting with is the one almost nobody asks. Every meeting you have ever attended sitting around a table was a meeting held at a fraction of the brain power that was actually available to the people in the room. Every brainstorm that got stuck inside a conference room. Every problem you tried to solve at a desk and gave up on. Every idea you could not quite get to. The intervention is the easiest one in modern science. No supplement. No app. No subscription. No training program. Just a pair of legs and 15 minutes. The Stanford lab proved it. The philosophers knew it. The neuroscience explains it. And almost everyone reading this is still trying to think their way out of problems sitting completely still.