Ruchi Patel

207 posts

Ruchi Patel

@_ruchipatel

Graduated but still working on my thesis project… • NCSU ‘17 • JHU ‘19 • UPenn ‘24

Philadelphia, PA Katılım Şubat 2020

206 Takip Edilen174 Takipçiler

Ruchi Patel retweetledi

Patrizia Porazzi@PatriziaPorazzi·25 Şub

Exciting news: EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models @Cancer_Cell @MarcoRuella @AlbertoCarturan @PuneethGuru_ @_ruchipatel @yunlin_zhang_ @guido_ghilardi and my stellar co-author Siena Nason cell.com/cancer-cell/ab…

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Nicholas Aboreden@ngaboreden·13 Oca

Excited to share our latest work on bioRxiv! Using cell-cycle dynamics and NIPBL depletion, we show that long-range enhancer interactions can form de novo without loop extrusion. Alternative mechanisms, including LDB1 and YY1, may play key roles.biorxiv.org/content/10.110…

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Nicholas Aboreden@ngaboreden·24 Ara

cell.com/molecular-cell… Our paper is now online @MolecularCell. Architectural protein LDB1 drives enhancer connectivity independently of CTCF/cohesin!

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Puneeth Guruprasad@PuneethGuru_·10 Ara

Wild experience to have seen our story shared at the #ASH24 Plenary in San Diego by my wonderful co-lead @Shan_Liu_ ! Looking forward to further proving that we can enhance cancer treatment by modulating readily-actionable patient lifestyle factors.

Penn Medicine@PennMedicine

A simple dietary supplement may provide a new approach to boost #CART cell function – hear more in the #ASH24 Plenary Session today. @MarcoRuella @MaayanLevy_Lab @PuneethGuru_ spr.ly/6015QKswz

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Alberto Carturan@AlbertoCarturan·8 Ara

Grateful to #ASH2024 for the chance to present our work on overcoming the absence of CD2:CD58 co-stimulation using an innovative PD1:iCD2 switch receptor. Thanks to my mentor @MarcoRuella and the @RuellaLab for their invaluable support. Excited to delve deeper into this approach!

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Penn Medicine@PennMedicine·3 Ara

Learn more about the exciting advances in blood cancer and benign hematology research that Penn Medicine and @PennCancer experts will be presenting at the @ASH_hematology Annual Meeting this weekend. #ASH24 spr.ly/6015txypB

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Ruchi Patel retweetledi

Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉@BLLPHD·5 Ara

#ASH24 Energy matters! Ketogenic Diet Enhances CAR T Cell Antitumor Function Via β-Hydroxybutyrate #CARTCell #TCell #tcellrx #immunotherapy @PennMedicine ash.confex.com/ash/2024/webpr…

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Română

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Penn Medicine@PennMedicine·9 Ara

A simple dietary supplement may provide a new approach to boost #CART cell function – hear more in the #ASH24 Plenary Session today. @MarcoRuella @MaayanLevy_Lab @PuneethGuru_ spr.ly/6015QKswz

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Ruchi Patel@_ruchipatel·27 Kas

Looking forward to discussing our latest work on CD5 next week! Register here to join: workcast.com/register?cpak=…

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Kartik Patel@KartikPatel___·3 Eyl

Very excited to share this work that could not have been done without the help of @RaisBahrami and @arnabguonc ! Big thank you to The Oncologist for this opportunity!

The Oncologist@OncJournal

High-sensitivity #ctDNA tests can be used to detect radiologically occult disease or minimal residual disease post-surgery & identify high-risk patients. This review summarizes current evidence, w/ focus on genitourinary tumors. @KartikPatel___ doi.org/10.1093/oncolo…

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Nicholas Aboreden@ngaboreden·25 Ağu

Happy to share my thesis work, now online at bioRxiv. We show that LDB1 organizes Enhancer-Promoter interaction networks and can function independently of cohesin! biorxiv.org/content/10.110…

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Penn Medicine - Abramson Cancer Center@PennCancer·5 Ağu

The effectiveness of #CARTCellTherapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, according to research led by @PennCancer's Dr. @MarcoRuella. spr.ly/6012YGdWi

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Penn Medicine CSO@PennMedCSO·2 Ağu

In a study published in @SciImmunology, @PennMedicine researchers identify #CD5 as an immune checkpoint protein & potential target of future cancer therapies ft. @MarcoRuella (@PennCancer) tinyurl.com/4nzzy3bs

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Ruchi Patel retweetledi

Parker Institute for Cancer Immunotherapy@parkerici·26 Tem

@UCLA @UCSF @cityofhope @DanaFarber A discovery from PICI Investigators @Penn has revealed that deleting the CD5 gene in CAR T cells significantly enhances their antitumor activity across multiple cancer types, opening new avenues for more potent and effective immunotherapies. science.org/doi/10.1126/sc… (5/5)

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ACIR@ACIR_org·1 Ağu

Patel et al. used the CRISPR-Cas9 system to ablate expression of the TCR-associated T cell inhibitory receptor CD5 from CAR T cells of several specificities and TCR-redirected T cells. bit.ly/4cnT9J7 @_ruchipatel @MarcoRuella @PennMedicine

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Ruchi Patel@_ruchipatel·31 Tem

Looking forward to joining @pillar_vc Frequency Bio's Cohort 10 next week! Excited to learn more about the biotech startup community.

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Science Immunology@SciImmunology·23 Tem

Genetic deletion of #CD5 in CAR T cells given to mice led to enhanced expansion, persistence, and anti-tumor effects against a range of preclinical solid and blood #cancer models. Read more in Science #Immunology: scim.ag/7LE

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Ruchi Patel retweetledi

Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉@BLLPHD·23 Tem

NEW -CD5 deletion enhances the antitumor activity of adoptive T cell therapies in vivo (liquid & solid cancer models) by enhancement of T signaling, cytotoxicity, and persistence. Stellar work by @_ruchipatel @MarcoRuella @PennMedicine @SciImmunology science.org/doi/10.1126/sc…

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Penn Medicine@PennMedicine·22 Tem

A @PennCancer research team led by @MarcoRuella has found that CD5 knockout boosts #CARTcell anti-tumor efficacy, in a preclinical study published in @SciImmunology. spr.ly/6013ihrxL

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Ruchi Patel@_ruchipatel·22 Tem

@jaehyukchoimd Thank you!

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Jaehyuk Choi@jaehyukchoimd·22 Tem

Congrats!

Ruchi Patel@_ruchipatel

Our paper is out in Science Immunology! As you can see from the author list, this was truly a team effort and I am so grateful for everyone’s support, especially @MarcoRuella for his mentorship. Next stop: continuing my thesis work into clinical translation at Vittoria Bio 🙂

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Keşfet

@Cancer_Cell @MarcoRuella @AlbertoCarturan @PuneethGuru_ @yunlin_zhang_ @guido_ghilardi @MolecularCell @Shan_Liu_