Dr. Antonio Dottore

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Dr. Antonio Dottore

Dr. Antonio Dottore

@aDottore

BoardDirecto. Researcher. Educator. Broadcaster. Loves gardening, baking sourdough bread. INSEAD MBA. PhD in Business Model Entrepreneurship. ComItEs

Adelaide, Australia Katılım Mart 2009
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Dr. Antonio Dottore
Dr. Antonio Dottore@aDottore·
@VanessaPirotta Exposing my ignorance: in what sense 'false'? Presumably, that's the name of the species (?) but why that name?
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Zinger III
Zinger III@oszinger·
@MarkDiStef I think the ECSA “eroded trust” when it incorrectly chose liberals with a 5% primary vote in the 2CP
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Mark Di Stefano
Mark Di Stefano@MarkDiStef·
These grifters are going to do this every election from now on. Monetising conspiracies to erode trust in institutions and the rule of law that are the only reason we aren’t living in some Latin American type backwater. They want to send us there.
John Adams@adamseconomics

🚨 BREAKING 🚨 Cairns News is reporting allegations of possible widespread ELECTION FRAUD in South Australia? What happened to the South Australian Electoral Commission’s official computers? Can we trust the official result? 🤔🤷‍♂️ cairnsnews.org/2026/03/22/sa-…

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Metabolic Uncle
Metabolic Uncle@MetabolicUncle·
If you want a real improvement in muscle endurance, or even sprint endurance for an ability to perform high-intensity tasks, then you would do exactly the opposite. You would essentially start with already higher CO2 levels and then perform the task. This would actually train your system. That would not be a circus trick that might lead to personal bests but doesn’t have any training effect. Then, for performance, you could use the circus trick.
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Chip
Chip@ChipGotIt_·
Wim Hof taught Marlon a new breathing method that led to a new push-up PR 🔥
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Dr. Antonio Dottore
Dr. Antonio Dottore@aDottore·
@MetabolicUncle Is the crux around duration? I think I remember a post where you mention you induce low levels of ketosis via overnight (?) fasting - or something like that.
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Metabolic Uncle
Metabolic Uncle@MetabolicUncle·
STOP SUPPRESSING YOUR METABOLISM The fasting trend rests on a conceptual error. People assume that forcing the body into stress mode produces metabolic benefits. It doesn't. What actually happens is predictable, measurable suppression of thyroid function and a shift toward inefficient cellular respiration. When you stop eating, your body doesn't care whether you're doing it voluntarily. The hormonal response is identical to starvation. Cortisol rises. Adrenaline rises. Insulin drops. Most critically, the conversion of T4 to T3 shuts down. This isn't speculation. Vagenakis showed it in 1977. After 72 hours of fasting, serum T3 dropped by roughly 50 percent. Reverse T3, the inactive form, increased proportionally. The body was actively blocking thyroid function. T4 production stayed normal, but peripheral conversion stopped. During actual famine, this makes sense. During elective fasting in a climate-controlled apartment, it's just damage. The subjective experience misleads. That alert, focused feeling comes from elevated stress hormones. You're running on adrenaline and cortisol, same as any acute stressor. The problem is duration. What works for minutes becomes destructive over weeks. Chronic cortisol wrecks sleep, breaks down muscle, leaches calcium from bone, suppresses immunity. The Randle cycle explains the metabolic shift. When you fast, adipose tissue dumps free fatty acids into the bloodstream. Those fatty acids directly block glucose oxidation at the mitochondrial level. You burn fat not because it's superior fuel but because glucose utilization is inhibited. This matters because glucose metabolism through oxidative phosphorylation is more efficient than fat oxidation. Glucose produces more ATP per oxygen molecule consumed. It generates less oxidative stress. It supports higher metabolic rate. Fat oxidation produces more reactive oxygen species, requires more oxygen for the same energy output, results in lower body temperature. You can measure this. People on prolonged low-carb or fasting regimens consistently show waking temperatures below 97.8°F. Yes, there are exemptions, specifically when people eat a lot of calories. Usually, the reduction in waking body temperature clearly indicates suppressed metabolic rate. Not optimization. Suppression. The autophagy argument needs examination. Yes, fasting upregulates autophagy signaling. But autophagy requires energy. Lysosomal degradation of damaged proteins and organelles needs ATP. When cellular energy production is suppressed through reduced T3 and forced fat metabolism, the cell may signal for autophagy but lack the energy to execute it. You can't run a cleaning program on a dying battery. Autophagy isn't unique to fasting anyway. Exercise activates it. Heat activates it. Adequate sleep activates it. The idea that skipping breakfast produces clinically meaningful autophagy in humans is extrapolated from rodent studies involving severe, prolonged calorie restriction. The dose-response doesn't translate to 16-hour overnight fasts in well-fed humans. Carbon dioxide production is another marker. Efficient glucose oxidation produces CO2, which has protective effects. It stabilizes proteins, improves oxygen delivery to tissues through the Bohr effect, has anti-inflammatory properties. Fat oxidation produces less CO2. The shift away from glucose metabolism during fasting reduces CO2 production, compounding the metabolic suppression. The fasting paradigm assumes periodic stress benefits the organism. But chronic stress pathway activation accelerates aging. Elevated cortisol, reduced thyroid function, increased reliance on fat oxidation, decreased CO2 production, lower body temperature. These are hallmarks of aging itself. Deliberately inducing them is the opposite of longevity optimization. Temperature and pulse reveal the truth. If waking temperature consistently sits below 97.8°F or resting pulse below 70 bpm, metabolic rate is suppressed. Those aren't arbitrary numbers. They're indicators of adequate cellular energy production, proper thyroid function, low stress hormone activity. The body doesn't benefit from chronic energy restriction. It benefits from adequate resources. Regular meals with sufficient carbohydrate keep insulin and thyroid function normal, cortisol low, cells running on preferred fuel. High metabolic rate allows efficient autophagy, proper immune function, optimal hormone production, effective stress response when genuinely needed. Fasting suppresses that rate. The body becomes cold, slow, defensive. That's not optimization. That's deterioration. Part 2 below covers a simplified basic practical nutritional approach to restore and maintain proper metabolic function.
Metabolic Uncle tweet media
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Tziporah Malkah
Tziporah Malkah@TziporahMalkah·
🫢 Looks like the ALP are going to take the seat of Unley in SA I was brought up in Unley Park and omg for them to go Left means that things are really crappy in Adelaide Thank goodness I left Adelaide is cooked 🤡
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Kevin Bonham
Kevin Bonham@kevinbonham·
Can't reply directly because this account has blocked me after I called out its malignant cluelessness re the Goldstein postcount, but the answer is one more than anybody else.
Kevin Bonham tweet media
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Giulio Meotti
Giulio Meotti@giuliomeotti·
Il premier australiano Albanese va in moschea non so a fare cosa. Se non era circondato dalla scorta lo linciavano. Bevessero dal calice amaro del multiculturalismo fallito
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Matt Barrie
Matt Barrie@matt_barrie·
preferential voting is designed to protect the uniparty
Matt Barrie tweet media
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Kevin Bonham
Kevin Bonham@kevinbonham·
Welcoming Morphett to the hall of seats I refused to call for a reason. #savotes
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Michael Atkinson
Michael Atkinson@MickAtko·
Adelaide journalists ought to find out the man behind atypicalthinking.com, which hosted Frances Bedford’s campaign website. Atypical thinking indeed. IMO she must have known.
Michael Atkinson tweet media
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Dr. Antonio Dottore
Dr. Antonio Dottore@aDottore·
Interesting implications re electorate's appetite/tolerance for reform by the @AlboMP Govt ⬇️ "The educated classes are not automatically drifting conservative just because they are middle class."
Kos Samaras@KosSamaras

Davenport is one of the cleanest examples of what has happened tonight in SA. This was once Liberal suburbia. Middle class, mortgage belt, family households, separate homes, multiple cars in the driveway. ABS Census data shows 47.4% of occupied dwellings are owned with a mortgage, 77.6% are family households, 92.9% are separate houses, and 67.1% of households have two or more motor vehicles. It is also more educated than the old Liberal base. And that is exactly why Davenport matters. Labor has now turned a seat it only cracked in 2022 into safe Labor territory. The educated middle has stayed with Labor, while the protest vote on the Right has peeled away to One Nation. The Liberals have been squeezed so badly they are running fourth. In a seat that once represented suburban Liberal stability, they are now barely relevant. This is the new fracture in Australian politics. The educated classes are not automatically drifting conservative just because they are middle class. In places like Davenport, they are proving willing to back Labor, while the angrier, anti-system vote is parking elsewhere. The result is a Liberal Party being hollowed out from both ends: losing educated suburban voters to Labor and losing its harder edge to One Nation. Davenport used to be a Liberal seat. Tonight, it looks like a warning about the future.

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Dr. Antonio Dottore
Dr. Antonio Dottore@aDottore·
@fbongiornoanu @PeterTRoberts I remember reading (as an undergrad) in one of Dean Jaensch's books that reform allowed the vote to reflect SA as being a 'natural' Labor state. My memory might be vague. It was in the previous century.
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Frank Bongiorno
Frank Bongiorno@fbongiornoanu·
Lots of talk on ABC coverage of lack of Liberal success in South Australia this century. In fact, Labor has dominated since 1965. I count just 5 terms for the Liberals in 60 years.
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Michael Atkinson
Michael Atkinson@MickAtko·
Frances Bedford running fifth in Florey with 6.5 p.c. of the vote. And that’s without its being revealed who hosted her campaign website.
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Dr. Antonio Dottore
Dr. Antonio Dottore@aDottore·
@MickAtko @Prakky It 'sounds' fine, used thus. Might need to re-write some grammar/vocabulary texts😉. (I understand 'versus' has become a verb for a substantial part of the population?)
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🍪 🧒 ®©
🍪 🧒 ®©@solo_dio_·
* cracks 5th beer* and ava good weekend folks ☕️☕️☕️☕️🫖🫖🫖🫖
🍪 🧒 ®© tweet media
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Dr. Antonio Dottore
Dr. Antonio Dottore@aDottore·
@regiedeluxe @solo_dio_ It's a 'display' of the yield curve, comparing bond yields at different time-to-maturity. Two main pieces of info: (1) Level of yields (2) Higher/lower yield for longer timeframes (ie upward/downward sloping curve) (2a) Downward sloping curve a good forecaster of recession
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