Aaron Ver Heul

LESSONS IN PEER REVIEW. @AnnaMTrier @aaronverheul submitted this paper in 2023 to @jacionline and it was outright rejected due to lack of mechanism. We are big fans of mechanism, but what made this paper so convincing to us was not fancy mechanism. It was ORTHOGONALITY. This is a major component of scientific rigor that reviewers often do not consider. We were able to validate so many aspects of the biology based on existing datasets from both mouse and humans from OTHER labs. This is what gave us tremendous confidence in our own findings. I ran into the Chief Editor in the public restroom at the annual @AAAAI_org and I told him that enhancing mechanism would be great, but it would be costly, and not change the impact. He invited us to resubmit. This paper is now required reading for the maintenance of certification for Allergy and Immunology. 1. Orthogonality is one of the greatest elements of rigor. 2. Data that cuts like hot knife through butter, may not always be fancy, but is a sign of robustness. 3. Editors matter. 4. You know the longterm impact of your own work better than anyone else. 5. Be ready to advocate for your science, even in the restroom.

Had to get in on this action. Spot on, right @itchdoctor?

Please see our new preprint online @biorxivpreprint and under review under the new @eLife model. This project has been going for 10 years after we repeatedly observed that Rag-/- get more severe #type2 #inflammation in the #skin than #adaptive #lymphocyte sufficient wild type mice. We believe this is in part due to intrinsic #ILC2 dysregulation due to #RAG deficiency and why patients with #Omenn syndrome get severe #eczema despite lacking #Tcells. We also think this paper is a perfect paper for the new @elife model. Congrats to @aaronverheul for completing what was started and greatly advanced by @madisonrmack and pushed forward by so many including @tamamamasatti @PhDTing Lydia Zamidar. A true labor of love and pain! One of the most challenging projects! biorxiv.org/content/10.110…

Couldn’t have had a better time at the @aaaai meeting after missing the last few. Great to see my mentor @itchdoctor and catch up on fantastic new science in #allergy. Already looking forward to next meeting in #WashingtonDC, hopefully with more #neuroimmune!

Congrats to Dr. Hu and to the Center!

BIG NEWS today the Mark Lebwohl Center for #Neuroinflammation and #Sensation + @MSHSDerm @SinaiBrain Nash Family Dept #Neuroscience has officially signed Dr. Hongzhen Hu as the new Scientific Director to help build our new Center in the beautiful West Manhattan Campus

@OrchardLab_Rob @JVirology @baldridge_lab Congrats!

Excited for the first paper from the lab published in @JVirology doi.org/10.1128/jvi.00… Great team effort co-led by Linley Pierce in the Orchard lab and Meagan Sullender in @baldridge_lab.

@JasminHerz1 Congrats!

I am thrilled to share our paper with you all today! We unraveled how dural lymphatic vessel dysfunction assists the behavioral response to peripheral inflammation: nature.com/articles/s4358…

@itchdoctor Congrats to Fang! Phenomenal!

Elated to share that former Kim Lab #postdoc Fang Wang was promoted to full #Professor and Vice Director of the Dept of #Dermatology at First Affiliated Hospital of China/Sun Yat-sen University - truly meteoric trajectory that my own trainee has the same seniority as me already!

@itchdoctor @NIH @NIH_NIAMS Many thanks to all my #mentors, #colleagues, and #family who helped get me here, and thanks to the reviewers @NIH_NIAMS for sharing my excitement about my proposal. It’s nice to get some extra wind in my sails from a good score!

The single most enriching experience of being a #PI is watching #trainees from your lab take off towards independence. So proud of #allergy #fellow #postdoc @aaronverheul on getting a fantastic score on his @NIH @NIH_NIAMS K08 grant! Thanks to all #colleagues and #labmates

🧵 I'm terrified thinking about the implications of the #SCOTUS decision for my pregnant patients! I'd like to share some insight from my experience as a high-risk obstetrician with the Justices...

This one hits close to home.

@itchdoctor @lilcham314 Reminiscent of the Seinfeld episode. There must be some mistake, that guy isn’t #therealitchdoctor!

This is not my car with Missouri plates. I really hope my wife @lilcham314 does not leave me for this guy. #therealitchdoctor

Congrats!

And we're published! Happy to see this story about #COPD #exosomes and #il33 out there in the world. @JCI_insight @WUSTLPulmonary @WUSTLdbbs @WUDeptMedicine @WashUDPS @nih_nhlbi @DorisDukeFdn @BWFUND @atscommunity insight.jci.org/articles/view/…

Congrats @carina_dehner everyone talks about how CPUO is #Th2 #type2 #inflammation but very little hard data on this. Great timing on your paper with our recent publication that #dupilumab may work! Thanks for your hard work on this! #itch #neuroimmune #CPUO

Very excited to share our new review on #mrgprs in #mucosal #sensation in @ELSneuroscience with @JuanInclanRico and @IshmailSaboor from @Penn Beyond somatosensation: Mrgprs in mucosal tissues sciencedirect.com/science/articl…

Congrats to Kim Lab postdoc Fang Wang on her paper in @CellCellPress today on #atopic #dermatitis #basophils #IgE #leukotriene and #itch #neuroimmune thk to @WUSTLmed @WUDeptMedicine @WashUDerm @Regeneron @JohnsHopkins @HopkinsNeuro @riken_en #dermtwitter authors.elsevier.com/a/1cPj2L7PXcMTo

Thanks to @NIH_CommonFund for sharing our work on #adipocyte #mitochondria transfer to #macrophages! It’s an honor to be part of the DP5 program. Grateful for the support! #postdoc applicants and #students DM us @BrestoffLab! @wusm_pathology @WUSTLmed @WUSTL @WUSTLdbbs