Aaron Edwards

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Aaron Edwards

Aaron Edwards

@aedwards02

Building noise-cancelling headphones for cell therapies @KiraGenBio starting with glioblastoma @HarvardHBS • @BeamTx • @BluebirdBio

Boston, MA Katılım Mart 2009
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Aaron Edwards
Aaron Edwards@aedwards02·
This is why we built @KiraGenBio. Base editing made CAR-T possible for patients like Alyssa, CURED of T-cell leukemia after every other option failed. We built the U.S. version at @BeamTx. Help us make more stories like Alyssa’s for patients with GBM and other solid tumors!
60 Minutes@60Minutes

After leukemia treatments failed, Alyssa Tapley, at age 13, was told she would die. Then, doctors tried an experimental gene-edited therapy. She became the first human to try the treatment made possible by U.S. federal funding. Now 16, she’s cancer-free and planning her future. cbsn.ws/4ou0OMt

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Aaron Edwards
Aaron Edwards@aedwards02·
Strong thread. We're living this every day at @KiraGenBio — building multiplex-edited CAR-T for solid tumors, protecting across 6 TME pathways where interactions, redundancy, and feedback determine whether a cell therapy works or fails. Single-KO maps miss this entirely. The "virtual cell" will require multiplex, TME-matched, time-resolved functional data, not more single-KO scRNA-seq.
Anshul Kundaje@anshulkundaje

Great to the see the flurry of single gene knockdown Perturb-seq like atlases from cell-lines, mouse brain etc over the last few days. These are undoubtedly very valuable datasets. I just want to re-iterate a few other very important expt. design considerations 1/

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Anshul Kundaje
Anshul Kundaje@anshulkundaje·
Jacob is being very kind here. @garrytan (who has blocked me) & YC seem to be astonishingly uncalibrated & unaware to be funding startups like these. It's just embarrassing at this point.
Anshul Kundaje tweet media
Jacob Schreiber@jmschreiber91

@garrytan It's always nice to see more people in this space, but "barely touched territory" seems exaggerated. To design these enhancers, they use a model from a paper that also does AI-based enhancer design! And they provided wetlab validation of their sequences.

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Aaron Edwards
Aaron Edwards@aedwards02·
Seeing Alex Marson as a guest on the @hubermanlab pod this week was SO COOL. Happy that a T cell guru was given an amazing spotlight to talk about cool work (and highly engineered cell therapies :) )
Andrew D. Huberman, Ph.D.@hubermanlab

The new Huberman Lab episode is out: Avoiding, Treating & Curing Cancer With the Immune System | Dr. Alex Marson 0:00 Alex Marson 2:21 Diseases & Current Biological Landscape; AI & Computational Tools 5:56 Immune System, Innate vs Adaptive Immune System 10:55 Thymus, T Cell Selection; B Cells & Antibodies 13:23 Sponsors: BetterHelp & Helix Sleep 16:11 Immune System Health, Sleep, Diet; Genes 20:56 Childhood Exposure & Allergy Prevention; Autoimmune Reactions 25:27 Whole Body Immune Response, Cytokines & Fever; Antibiotics 30:51 Cancer; Mutations & Cell Regulation; Smoking, BRCA Mutations, Sunlight 38:27 BRAC Mutations, Mutagens, Pesticides 42:33 Sponsor: AG1 43:57 X-Rays & Airport Scanners, Carcinogen vs Mutagen, Charred Meat, Food Dye 49:34 Immune-Based Cancer Treatment, Checkpoint Inhibitors, CAR T-Cell Therapy 59:04 CRISPR, Immunotherapies 1:02:52 Age & Cancer Risk; CAR T-Cells, Targets & Side Effects; Ketogenic Diet 1:08:27 CRISPR Discovery & Mechanism 1:17:06 CRISPR Precision, Risk & Benefit; CRISPR Technology Evolution 1:20:57 Sponsor: LMNT 1:22:17 CRISPR Cell Delivery, Clinical Trials; Treating Early Cancers & Prevention 1:33:47 Liposomes, Engineered Viruses, Lipid Nanoparticles (LNPs), Vaccines 1:39:57 COVID Pandemic & Trust in Science, mRNA Vaccine 1:47:51 Sponsor: Function 1:49:39 Drug Delivery to Cancer, Immunotoxins, T-Cell Engagers; AI Protein Targets 1:55:45 CRISPR Embryo Modification, Ethics; Heritable Gene Editing, Diversity 2:05:42 Deep Sequencing Embryos, Diversity; Overcoming Adversity & Resilience 2:10:44 Upcoming Therapeutics, Autoimmunity & CAR T-Cells, CRISPR & Gene Function 2:17:55 Banking T Cells or iPSCs?, Future of Cell Programming 2:24:41 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Includes paid partnerships.

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Aaron Edwards
Aaron Edwards@aedwards02·
@exosome CAR-T are remarkably modifiable. Have been obsessed for a decade now
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Aaron Edwards
Aaron Edwards@aedwards02·
@steffingomes @DrNeilStone Surely you’ve heard about the underground bunkers where they harvest unvaccinated blood. Think “The Island”, just blood instead of organs.
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@DrNeilStone Set aside scientific reasons (your point is valid) - even practically, how are you going to find "unvaccinated blood"? Practically everyone alive today old enough to donate blood has had some type of vaccination.
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Aaron Edwards retweetledi
Adam Feuerstein ✡️
Adam Feuerstein ✡️@adamfeuerstein·
VInay Prasad is out at the FDA, per the WSJ.
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Aaron Edwards
Aaron Edwards@aedwards02·
It’s appalling that the commercial breaks during The Beauty on @hulu are all smart scales and supplements. Do better yall that’s some predatory shiz.
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Aaron Edwards
Aaron Edwards@aedwards02·
@jrkelly This is even more triggering because I have been binge re-watching the series now that Netflix added to catalogue this week!
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Seth Bannon
Seth Bannon@sethbannon·
Anyone who turns war into a game – a fun adventure with a high energy soundtrack – is poisoning your soul.
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