Anosh Steffin Gomes

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Anosh Steffin Gomes

Anosh Steffin Gomes

@steffingomes

Founder - stealth biotech 🧬 | Obsessed about Mitochondrial Dysfunction ⚡️ | Nullius in verba

Minneapolis, MN Katılım Mayıs 2020
133 Takip Edilen153 Takipçiler
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
2025 has been the most pivotal year of my life. I quit my job to start a biotech company - with the mission to discover & develop medicines that can change people's lives. What I hold in my hands is the first drug that my team and I created, atom by atom, and that could potentially help cancer patients in the future. Earlier this year, when my co-founder and I had a novel idea for a cancer drug, we pitched to investors for funding. The biotech funding environment sucked, and we couldn't raise (AI was sucking up all the oxygen). So we funded it with our own savings. Fast forward 9 months, we have our lead drug + in vivo POC data and more - all without a single dollar in investor funding. Mid-year, we raised a modest sum to further support development. If we pull this off - we will have bootstrapped a biotech company, which is wild to say out loud. Discovering cures for diseases is what I want to do for the rest of my life. I can't believe I get to do this now, and I want to share my journey with all of you. We have some amazing things in store of 2026! LFG 🚀
Anosh Steffin Gomes tweet mediaAnosh Steffin Gomes tweet media
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@elonmusk @jonatanpallesen Worthless having neglected kids grow up into unadjusted adults rather than have 1-2 kids that are provided enough attention, such that they become stellar citizens. I get the population crisis, but it's unfair to birth kids with the intention of solving the population crisis.
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
Both approaches are weak imo. Over indexing on credentials or "my forever person" are the reason why this institution has near 50% failure rates. A better approach is to not assume this is forever, but ask how well you'd partner "in the interim". My wife and I asked this of ourselves and somehow are in year 12, it's glorious.
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signüll
signüll@signulll·
it’s fascinating that today modern humans are still running a credential matching algorithm disguised as attraction. e.g. 6ft, symmetrical face, status markers… these are visible proxies that compress well into a profile or a first impression yet will never tell you whether or not someone will abandon you in times of high variance entropy like if you get sick or something. the latter gets systematically underweighted because it doesn’t resolve until the option period has long expired. only when you’re older you realize that the only thing that survives the death of eros is logos.
signüll tweet media
𑣲@holylipss

imagine connecting so deeply with someone that your dates revolve around walking and talking for hours

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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@parmita I never understood the concept of ghosting. If you're not interested in someone, whether in a romantic or even a business relationship, just say so politely and move on.
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Parmita Mishra
Parmita Mishra@parmita·
i would ban ghosting if I were the queen of California you would be banished to the other states if you ghosted people. once you cleared the backlog you’d be let back in
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@Ben_M_McLeod AI is making it easier to access biology, that's true. Disagree with the gatekeeping part. True gatekeeping is the drug development process itself (going through phase 1–3 trials). Anyone can make an N=1 medicine. It's a whole other ballgame making meds for a population.
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Ben McLeod
Ben McLeod@Ben_M_McLeod·
A 17-year-old is building a lung cancer gene therapy. A billionaire with no biology background just cleared his own osteosarcoma using AI, maximal diagnostics, and founder-mode thinking. The knowledge moat, that once defined who belonged in the biopharma industry, is being filled in fast. BioPharma built its gatekeeping on scientific expertise (that required large amounts of time and money) AI has commoditized that. The tech bros are coming. My post on Substack makes the more in-depth case for why we should welcome them with open arms. Article link: substack.com/home/post/p-19…
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@devahaz It wasn't only about national debt. They all predicted nearly a doubling of growth rates, around 4–5%, inflation coming down, and rates needing to be cut - until Trump pulled a reverse Cramer.
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Deva Hazarika
Deva Hazarika@devahaz·
Elon, Andreesen, Sacks, Ackman, Chamath, Vivek, on and on, I remember when for all these guys it was critical to elect Trump because our national debt was a crisis and existential threat to the future of America only he would tackle. Don’t hear so much about that anymore.
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@ValerieAnne1970 Now flip the question: what adverse events from those infections would Brent have been comfortable risking for his children if they hadn’t been vaccinated?
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Valerie Anne Smith
Valerie Anne Smith@ValerieAnne1970·
“Adverse events from vaccines are far more common than we imagine...my allergy is likely the result of a vaccine adjuvant & I will never be free from it.” ~Bret Weinstein “My kids suffer from allergies. If I had it to do over again, I would not give any vaccines to my children.”
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@odedanilo Yes, back in my early 20s. It was one of the most formative years for me. At that time, I actually didn't appreciate it enough. Now in my mid-30s it's an amazing experience to have my own company.
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Danilo
Danilo@odedanilo·
Have you ever actually lived ALONE? No kids. No roommates. No boyfriend/girlfriend/spouse. No pets. Just you??
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Safi Qadir
Safi Qadir@safizaq·
The Marina is the most confusing part of SF why is everyone always running? sir it’s 2pm, don’t you have shareholder value to maximize
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@NoContextHumans Quite the opposite. The differences in the prices shows what's demanded. If enough people demanded the cup of fruit, it can absolutely come down even more.
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signüll
signüll@signulll·
ditto. for me san francisco started to feel like a time loop. like i was part of some sci fi show or something. i noticed i was having the same conversations, same thoughts around the same damn topics.. everything was just recombined slightly each day like some low variance simulation. it was eerie as hell. there was almost no real diversity of interest besides the current thing. everyone pulled from the same narrow band of ideas, so even new conversations felt preloaded. & then once that got saturated ppl started reaching for contrarian takes which were less from conviction & more cuz differentiation itself became the game. so you end up with this weird artificial counterculture layered on top of an already homogeneous culture. what a fascinating place.
Shaun Maguire@shaunmmaguire

🎯 I first moved to Silicon Valley in 2007 It was a magical and non-consensus time to be there By ~2016 tech was consensus A precursor that led to group think and DEI mania For the last decade I’ve spent ~3 months/year in SV and the rest away It’s hard but fuels creativity

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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@newstart_2024 Dr. Shiong is making it sound like immunotherapy (T cells or NK cells) is something novel. It's not. Keytruda, Opdivo, and countless others have transformed cancer treatment for over a decade. Also - MTD is not the gold standard, that's false, overall survival is.
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Camus
Camus@newstart_2024·
Dr. Patrick Soon-Shiong to Megyn Kelly: For 75 years we've treated cancer like a war—nuking tumors with poisons (chemo) and radiation while simultaneously destroying the immune system's natural killer cells and T-cells. The vicious cycle: Chemo → anemia → give Epogen → more chemo → wipe out neutrophils → give Neupogen → more chemo → destroy more lymphocytes/NK cells. FDA's gold standard? Maximum Tolerated Dose (MTD) — push the poison just below what kills the patient, measure tumor shrinkage (response rate), but ignore overall survival. Soon-Shiong: “The tumor shrinks… but the patient dies. We’re not really interested in overall survival as an endpoint. That is today’s thinking.” Megyn Kelly: “It seems to be a willing choice because we’ve gone so long without making much progress.” Clip from this 2:33 bombshell — the cancer “war” paradigm laid bare. Is MTD + response-rate obsession the reason we’re still losing the fight? Or is this the best we’ve got until something radically better arrives? Your take—seriously, drop it below.
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@WallStreetMav Great job in losing weight and lowering fasting glucose. Just a quick clarification - prediabetes is much easier to reverse and control than diabetes, which is way harder without meds, not impossible but very difficult.
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Wall Street Mav
Wall Street Mav@WallStreetMav·
I was advised by my doctor that I am pre-diabetes. So I started the keto diet a few weeks ago, have lost 20 lbs just eating steaks and eggs, water. Today was my first fasting blood sugar test below 100 mg/dL. It was 96. Keto diet does work to fix diabetes, no medicine required.
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@growing_daniel The primary reason for an RCT even in with a one off MRNA vaccine is to determine if the effect is a true therapeutic effect or placebo driven at a population level. If it is a true therapeutic effect, then you can administer a one off MRNA treatment to a larger population.
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Daniel
Daniel@growing_daniel·
Can someone who knows things tell me why a randomized controlled trial would be relevant to a one-off MRNA vaccine custom made for an individual person
Patrick Heizer@PatrickHeizer

Sorry to be the downer because this is an impressive story in some senses. But it is ~trivially easy to make a single mRNA vaccine. It's not hard. I cure mice of various cancers with various therapeutics all the time. I've made mice lose more weight in a month than tirzepatide does in a year. What is hard and expensive is proving its BOTH safe AND effective **in a randomized and controlled study in humans** while ALSO manufacturing it at clinical scale and grade. I am happy for this man and his dog. It is impressive. But y'all are overhyping it.

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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@ShaanVP I moved to the US back in 2010. Since then, every Sunday morning here/evening there. I called Mom and Dad. 16 years and a family later, I still do. Every single Sunday without fail. They ask me to reschedule sometimes because they're having a date night 🤣
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@Cobratate You just sent your mum "Hi"? Even scammers have a bit more emotional tone in their messages.
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Andrew Tate
Andrew Tate@Cobratate·
Happy Mother's Day ❤️
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@jonathanstea Agreed, but the anti-vax movement is too dumb to understand that vaccinating oneself is actually quite the act of self-interest. You introduce herd immunity to protect yourself AND others. When a lethal virus rips through society, you'll wish you and others were vaccinated.
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@redpillb0t Truly dumb take. Ask yourself - Pharma makes ivermectin and sells it. If it does work as claimed, why wouldn't just ONE pharma company sell ivermectin ANYWHERE in the world, for treating COVID? Because it doesn't work. No regulator around the world will approve it.
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redpillbot
redpillbot@redpillb0t·
Fauci didn’t stop us from taking Ivermectin because it doesn’t work. Fauci stopped us from taking Ivermectin because it does work. They knowingly killed people.
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@ZKForTre It's the unwavering faith in one pharma product (mfg by the same pharma companies they criticize for profiteering) over others. Why wouldn't a pharma that already sells ivermectin, not want to sell more, if it indeed works as these people claim? This bias is truly dumb.
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@donatelli2026 Sir please. Intersection of B2B SAAS and AI is not the same as Renaissance. SF is great, but let's not get ahead of ourselves.
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Don
Don@donatelli2026·
being in san francisco now is the equivalent to being in florence during the renaissance
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Anosh Steffin Gomes
Anosh Steffin Gomes@steffingomes·
@PathOfMen_ Teeth is a remarkable structure, they don't decay even after the organism dies because of enamel, which is largely made up of hydroxyapatite.
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Path of Men
Path of Men@PathOfMen_·
Why don't animals' teeth decay even though they don't brush them?
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Keşfet

@elonmusk @jonatanpallesen @parmita @Ben_M_McLeod @devahaz @ValerieAnne1970 @odedanilo @safizaq