Soumya Bhattacharyya

Excited to see out in @Nature my postdoc work! “Membrane prewetting by #condensates promotes tight junction belt formation” How do #tightjunctions form a belt in #epithelia sealing our body cavities? @Honigmann_Lab @mpicbg @BIOTEC_TUD w/ #Jülicher @mpi_pks doi.org/10.1038/s41586…

Great Viewpoint from Vivek Malhotra @JCellBiol! COPII proteins, essential for cargo export from the ER, form not only coated small vesicles but also collars at tubule necks and phase-separate into liquid-like condensates, adapting to physiological demand. rupress.org/jcb/article/22…

1/n My postdoc work on the evolution of mitosis in Ichthyosporea @Dey_Gautam @dudin_o @SchwabYannick groups is out @Nature shorturl.at/KPRQw Art by @nirupa_rao contrast fungal-like closed with animal-like open mitosis. Why do cells carry out mitosis in different ways?

#FluorescenceFriday #cellbiology #bioart Three examples of mitochondrial remodeling by lysosomes/late endosomes actively transported along microtubules, as seen by grazing incidence structured illumination microscopy at 1-2 frames/sec. doi.org/10.1016/j.cell…

Happy to share this mini-review that @TPucadyil and I wrote for Biochemical Society Transactions. portlandpress.com/biochemsoctran…

@PNASNews @TPucadyil @IISERPune Thank you all!

Online now @PNASNews! It was fantastic to work with @TPucadyil on this. I learnt so much from him in putting this together and had a fabulous time completing my PhD in his lab @IISERPune. pnas.org/doi/10.1073/pn…

@iam_Mridula @PNASNews @TPucadyil @IISERPune Thanks Mridula!

@afororange @PNASNews @TPucadyil @IISERPune Congrats Soumya! 👏

@ghosharindam_92 @PNASNews @TPucadyil @IISERPune Thank you!

@afororange @PNASNews @TPucadyil @IISERPune Many Congratulations Soumya!

🙌🏿 Congratulations to Vivek Malhotra on his election to the American Academy of Arts and Sciences @americanacad Dr Malhotra, group leader of the Intracellular Compartmentation lab at #CRG, joins a distinguished collection of leaders and professionals across many fields.

@MeghdutSengupta @naacl @roxanneelbaff @miladalsh @AIHannover @trr_318 @webis_de Dónde está el enlace al manuscrito?

Our paper 'Analyzing the use of metaphors in news editorials for political framing' got accepted at the @naacl mains! Congratulations to all the co-authors @roxanneelbaff @miladalsh and Henning Wachsmuth. @AIHannover @trr_318 @webis_de #NLP #NLProc. See you in Mexico!

Our biophysical model in @PNASNews! ER export of collagen driven by a mechanochemical ratchet formed by expansion-contraction of intrinsically disordered regions (IDRs) of TANGO1, and gradients of pH/HSP47. IDR “breathing” produces work with each breath. pnas.org/doi/10.1073/pn…

How can lysosomes, when ruptured, maintain stability allowing for repair? Glad to share @Nature nature.com/articles/s4158… the function of stress granules (SG) as molecular plugs that stabilise damaged membranes @TheCrick @maxgabgut #condensates #lysosomes #TB👇Thread

Collagen transport through inter-compartmental tunnels! Our theoretical model, led by the Pincet group @LP_ENS_, for how molecular gradients between organelles drive cargo transport through a tunnel - even without a cargo receptor. biorxiv.org/content/10.110…

Happy to share with you, our piece on how the molecular membrane fission machine - dynamin is regulated by 'gears' in its membrane binding PH-domain. @TPucadyil and I curated this brief review for Current Opinion in Cell Biology. Now online: authors.elsevier.com/c/1hPJK3PA3sV0…

TransitID is out today in Cell! This is a proximity labeling method for unbiased discovery of endogenous proteins that traffick from a defined “source” location to a defined “destination” location. TransitID uses sequential labeling by TurboID in the source, followed by a chase period (minutes to hours) and then 1-minute APEX tagging in the destination compartment. Proteins tagged by both enzymes are enriched with streptavidin and anti-fluorescein antibody, and identified by mass spec. We explore 4 intracellular and intercellular applications of TransitID: - discovery of locally translated mitochondrial proteins (translated at OMM, then imported into mito matrix) - mapping proteins whose cytoplasm-to-nucleus shuttling is dampened by stress - discovery of proteins that transit between nucleolus & stress granules during stress & stress recovery - analysis of proteins that traffic intercellularly bw tumor cells & macrophages Work of amazingly talented co-first authors @WeiQinChemBio and @CheahJoleen, and collaborators Steve Carr @namude & Paul Taylor authors.elsevier.com/a/1hKLcL7PXmcqA

New on BioRxiv: Adhesion energy controls lipid-binding mediated endocytosis. A group effort lead by @RaluucaG with contributions from our friends @taraskalab @DimovaLab @cmatthaeus2 and Thomas Weikl @MpiciPotsdam @FUBiochemistry @FU_Berlin biorxiv.org/content/10.110…

1/2 Our stressed-out PhD scholars deserve a long-overdue increase in their stipends. The revision was due in 2022 after an already delayed raise in 2019. How can they meet their daily needs & undertake research amid rising inflation? @IndiaDST indiatoday.in/education-toda…

Our work about superPLD is now published! In this paper, we describe how we can harness mammalian cell-based directed evolution to engineer a membrane editor (phospholipase D; PLD) with superior performance in mammalian cells. 1/n nature.com/articles/s4155…