Andrew Harrison

Happy to share the final chapter of my PhD @uconnhealth out today in @NatImmunol ! Here we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes #metabolism #Immunology @NaturePortfolio nature.com/articles/s4159… 1/

@DrShrutiNaik Extraordinary work! Congratulations!

Our new Nature study, lead by @yuexing identifies a brief early-life window when skin dendritic cells sense common allergens and trigger inflammation right in the skin without migrating to lymph nodes. We define this in-situ activation state as peripheral immune inducer (pii)DC, and show it emerges because of a still-maturing HPA axis and low systemic glucocorticoids. #Naiklab 👉Key takeaways: 1. Early-life immunity plays by different rules. During this window, innate responses to allergens in skin are heighted. 2. Hormones shape immunity in real time. Developmental neuroendocrine states profoundly tune how the immune system reacts, and can set the stage for inflammatory disease. Thanks our incredible collaborators @niroanandalab @EmmaGuttman @kamalkhanna @Teresalu @Amandalund and others. Our funders @NIAIDNews @NIH @DermalCell @SinaiImmunol @MSHSDerm nature.com/articles/s4158…

@RathinamVA Congrats!!!

Shiga toxin-induced cell death—the underlying cause of a potentially fatal renal disease in children—occurs via pyroptosis, not apoptosis as previously thought, and is driven by an intriguing NLRP1->Caspase-3-> gasdermin E pathway. Congrats to Priya's lab! pnas.org/doi/10.1073/pn…

@RathinamVA @uconnhealth @UConnResearch On a roll! Congratulations to the team and @VinnieViruses on the fabulous work!

Why does RNA undergo glycosylation? Excited to have our new paper out. We in collab w/ Ryan Flynn show N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells. nature.com/articles/s4158… @uconnhealth @UConnResearch

@RathinamVA @UConnResearch @uconnhealth Congratulations team!!

We are excite d to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network. cell.com/cell-reports/f… @uconnresearch @uconnhealth 1/2

@ZhichaoFan On a roll!! Congratulations to everyone!

Congratulations to my postdoc Doulathunnisa Ahamed Younis and many thanks to our amazing collaborators!

We are happy to share that our work on cystic fibrosis and integrin clustering has been published @PNASNews CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation | PNAS pnas.org/doi/10.1073/pn…

@ZhichaoFan Congratulations, Zhichao!!

We are happy to share that our work on kindlin-3 and integrin clustering has been published at Cell Communication and Signaling. link.springer.com/10.1186/s12964…

@DuomengYang @PENGHUAWANG3 Cool!

GLUT4' novel function in antiviral response！News from Uconn Today！@agharrison6 @PENGHUAWANG3

@RathinamVA YES!! So happy to see this out! Congratulations to you all!

Full-text link: authors.elsevier.com/a/1kMQgL7PXqSmX 3/3

So excited to have this paper out now! Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. cell.com/cell/abstract/… @uconnresearch @uconnhealth 1/3

@nandangokhale Fabulous work!

Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology @RamLabUW science.org/doi/10.1126/sc…

@Ella_Maru @uconnhealth @NatImmunol @NaturePortfolio Hi! We tried infecting adipocytes (3t3-glut4) but they were highly susceptible to infection, while myotubes are more resilient so we could study it better. Though, I would expect adipocytes to have faster kinetics b/c they have more GSVs that could be mobilized.

@agharrison6 @uconnhealth @NatImmunol @NaturePortfolio Brilliant work, Andrew! Have you tested if GLUT4’s translocation kinetics differ across adipose vs. muscle cells during infection?

Happy to share the final chapter of my PhD @uconnhealth out today in @NatImmunol ! Here we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes #metabolism #Immunology @NaturePortfolio nature.com/articles/s4159… 1/

@LabWaggoner @NatImmunol @DuomengYang @PENGHUAWANG3 Thanks for the highlight!

UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling @NatImmunol @agharrison6 @DuomengYang @PENGHUAWANG3 nature.com/articles/s4159…

@ZhichaoFan @uconnhealth @NatImmunol @NaturePortfolio Thanks Zhichao! Hope all is well!

@agharrison6 @uconnhealth @NatImmunol @NaturePortfolio Congratulations!

@takarginov @PENGHUAWANG3 It was a privilege to work alongside you, my friend. Thank you for all the memories and our brainstorming sessions!

Check out this awesome article by Andrew during his time in @PENGHUAWANG3 's lab on GLUT4's role in innate immunity - it was a privilege to get to watch this work go from idea to reality during our PhDs in our many "window chats" and contribute to the project!

@dolly_puja @uconnhealth @NatImmunol @NaturePortfolio Thank you so much, Puja! Hope all is well!

@agharrison6 @uconnhealth @NatImmunol @NaturePortfolio Congratulations, Andrew, Dr. Wang and the entire team! So happy to see this published😊

@RathinamVA @DuomengYang @PENGHUAWANG3 @uconnhealth @UConnResearch Thanks for the repost, Vijay! Incredibly grateful for all your help on this & throughout my PhD!

UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling! Exciting findings from our neighbors @agharrison6 @DuomengYang @PENGHUAWANG3 Penghua Wang lab @uconnhealth @UConnResearch

@AUmmarino @uconnhealth @NatImmunol @NaturePortfolio Thanks Aldo!!

@agharrison6 @uconnhealth @NatImmunol @NaturePortfolio Congratulations @agharrison6 !

@Lo_Zanzi @DuomengYang @NatImmunol Thank you so much for the highlight, Ivan!!

#LocationLocationLocation! @agharrison6 @DuomengYang Wang &co show @NatImmunol that in homeostasis GLUT4 is trapped in the Golgi, but upon virus encounter it relocates to the plasma membrane where it segregates & prevents signaling of RIG-I-like receptors! doi.org/10.1038/s41590…

@kjena21 @uconnhealth @NatImmunol @NaturePortfolio Thanks Kautilya!!

@agharrison6 @uconnhealth @NatImmunol @NaturePortfolio Many many congratulations @agharrison6 d

@DuomengYang Thank you, Danny! You were so instrumental in this work and couldn’t have done it without you!

The power of UBXN9-GLUT4 axis to regulate RLRs！Very very happy to see this impressive work out finally！Big congrats to my best friend and lovely colleague Dr. Andrew Harrison！

@connorc110 Thanks Conner!! Appreciate all your help!