Michael Weiss

this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get

I’m not an aging biologist, but I have to say — @davidasinclair is one of the clearest science communicators out there. The way he explains aging really stuck with me: it’s not just “damage,” it’s loss of biological information. And in theory, information can be restored. 75% age reversal in animals in 6 weeks. FDA-cleared human trial now underway. Video source : @vitrupo

The recording of history should be a raw data feed of the present. Let the future interpret the data as they see fit.

In the future, we will be shocked people once waited to get a disease before they were treated

Demis is a genius and he should be given all resources in the world to make this happen.

Shift Bio is leading the way in using foundation models for rejuvenation research! Excited to see the breakthroughs they’ll bring in the years ahead!

HOLY SHIT IT'S HAPPENING AI can now write genomes from scratch. Arc Institute an NVIDIA just published Evo-2, the largest AI model for biology, trained on 9.3 trillion DNA base pairs spanning the entire tree of life. it doesn’t just analyze genomes. it creates them 1/

Healing has always been a reactive practice. When someone gets sick or hurt and shows symptoms is when treatment gets applied. The shift to proactive medicine is what longevity biotech / regenerative medicine / aging interventions are all about. The only symptoms humans of the near future should suffer from is a bioclock that says a bit of aging occurred.

Bold statement, but it's great getting more people to attach health and longevity to AI's progress.

It's so cool this happened, let alone 60 years ago... In 1962, Gurdon discovered that the specialization of cells is reversible. He replaced the nucleus of a frog egg cell with the nucleus of a mature intestinal cell, and the egg cell developed into a tadpole.

FT reports from Davos that Isomorphic Labs' co-founder said they'll have an AI-designed drug in trials by end of '25. "We’re looking at oncology, cardiovascular, neurodegeneration, all the big disease areas, & I think by the end of this year, we’ll have our 1st drug." Link: ft.com/content/41b51d…

It’s an incredible time in biomedicine. We’re applying advances in large language models to accelerate research. We recently shared initial cell models that will help researchers discover the cellular basis of health & disease, with lots more to come czi.co/4g1jTSa

sam altman: “we will see diseases get cured at an unprecedented rate … what this will do to cure the diseases at a rapid rapid rate” immortality is not too far ahead. we live in the most incredible of times

That may be the case, but since we can change somatic mutations through epigenetic tinkering (ie oskm), this zinger ain’t so zingy.

1/ 🧵Announcing CORHORT 6 of the Longevity Biotech Fellowship —the most hardcore community of longevity accelerationists! Join 700 members working to SOLVE aging entirely. ⌛️Deadline: Mar 14 Kickoff Retreat: Mar 31 - Apr 4 in Berkeley. 👉Apply: longbiofellowship.org/apply

I’ve allocated $650,000 to longevity. Aging is the world’s largest untapped market...here's why:

OpenAI built a model to improve "reprogramming" of cells by suggesting how to re-engineer Yamanaka factors. Did the work with Retro Bio, longevity company funded by Sam Altman. technologyreview.com/2025/01/17/111…

This tweet just made the @WSJ! @X helping to make news yet again. We’re in a once in a decade, 2 month window for policy change to catalyze a world for longevity interventions to help prevent awful diseases. What do ppl think is most impactful lever that the new admin can pull?!?

Gene editing > epigenome editing > what’s next?