Hannah Alfonsa

"Sleep-wake related changes in intracellular chloride regulate plasticity at glutamatergic cortical synapses" is now out at @CurrentBiology (1/5 )#core-collateral-metrics" target="_blank" rel="nofollow noopener">cell.com/current-biolog…

We conclude that chloride dynamics provide a functional link between changes in a neuron’s physiology that are associated with sleep-wake history and the mechanisms responsible for the induction of glutamatergic synaptic plasticity. (5/5)

This increased depolarization results in increased LTP. Pharmacological manipulation associated with reduced chloride decreases membrane depolarization and LTP level. (4/5)

"Sleep-wake related changes in intracellular chloride regulate plasticity at glutamatergic cortical synapses" is now out at @CurrentBiology (1/5 )#core-collateral-metrics" target="_blank" rel="nofollow noopener">cell.com/current-biolog…

Sleep-wake-related changes in intracellular chloride regulate plasticity at glutamatergic cortical synapses: Current Biology cell.com/current-biolog…

We conclude that chloride dynamics provide a functional link between changes in a neuron’s physiology that are associated with sleep-wake history and the mechanisms responsible for the induction of glutamatergic synaptic plasticity.

This increased depolarization results in increased LTP. Pharmacological manipulation associated with reduced chloride decreases membrane depolarization and LTP level.

"Sleep-wake related changes in intracellular chloride regulate plasticity at glutamatergic cortical synapses" is now out at @CurrentBiology authors.elsevier.com/sd/article/S09…

@NatalieHauglund Many congratulations Natalie!

Great article in Science about our study 🤗🧠🚿 science.org/content/articl…

Working situation today! Only for a quick revision of a manuscript then will go back to full time baby cuddling 🥰

Interesting next step in the cortical reactivation story

Ever wanted to explore the driving forces underlying inhibitory neuronal signalling? We did! So, for my MSc in @JosephRaimondo lab, we developed the all-optical approach ORCHID - all-Optical Reporting of CHloride Ion Driving force. Now out in @NatureComms nature.com/articles/s4146…

@WElgrawani @VVyazovskiy It's nice when different works fit together. Congrats on the paper @WElgrawani

@alfonsahannah @VVyazovskiy Hi Hannah, This was in fact a nice part in my discussion that i had to unfortunately trim due to word counts limits

BDNF-TrkB signaling orchestrates the buildup process of local sleep: Cell Reports cell.com/cell-reports/f…

Somonotate – a new sleep scoring algorithm by twitterless Paul Brodersen tested on @VVyazovskiy lab datasets. Advantages: (1) robust (2) accuracy exceeds expert consensus (3) certainty measure facilitates visual checks and detection of intermediate states journals.plos.org/ploscompbiol/a…

Would be great to try/validate this on other data sets. Please help to share and let us know whether and how this worked for you!

Sleep and circadian rhythmicity as entangled processes serving homeostasis | Nature Reviews Neuroscience nature.com/articles/s4158…