
Leo Amigoni
1.1K posts

Leo Amigoni
@amigoni
Engineer & AI Enthusiast | Passionate about systems to help people build & make work more fulfilling, AI, and seamless collaboration.




@diana_dukic What needs to be better?

this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get


Announcing Personal Computer. Personal Computer is an always on, local merge with Perplexity Computer that works for you 24/7. It's personal, secure, and works across your files, apps, and sessions through a continuously running Mac mini.




The implication of that is that there is no formal specification that will suffice to adequately define the product. The only true way to define an AI generated product is to babysit the entire process from beginning to end, and beyond. It means that every new feature you add requires that you also ensure that the AI has not changed something else that used to work, has not voided a test because it failed. This seems like a herculean human task that is even more difficult than having the humans write the code.






I find myself wanting a way to share and collaborate on markdown documents. @github isn't quite right - committing is too heavy, no simultaneous editing, web UI for review and editing isn't easy enough. @NotionHQ isn't quite right - hard to write locally (e.g. claude to edit) and sync easily, editing experience is more annoying than pure markdown. What I want is hosted markdown collaboration that easily let's me edit a file locally, and commits to github with an AI generated commit message regularly. Anyone know of such a tool?


Sneak preview of the new @RepoPrompt agent ux coming soon. Still WIP, and lots more to come










