Aino-Maija Leppä

🚨Thrilled to share our latest work: “Tumor-Infiltrating Clonal Hematopoiesis” @NEJM - we investigated how age-related blood mutations impact cancer when they infiltrate tumors, with @Elsa2Bernard Maria Zagorulya, @PapaemmanuilLab @CharlesSwanton + more nejm.org/doi/full/10.10…

🚨 Paper out in Nature 🚨 Amazing news from the Trumpp Lab @HI_STEM_lab performed by Vera Thiel @VT199104, Simon Renders @SimonRenders and Jasper Panten! Discover how tumors interact with nerve cells! 👇👇👇  nature.com/articles/s4158… #CancerResearch #Neuroscience

After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳 nature.com/articles/s4158… LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space. Some highlights⬇️

I'm very thankful to everyone involved in the study! The project would not have been possible without my co-firsts @KfdG_1236 and @hyobin_jeong and co-lasts Andreas Trumpp, @JanKorbel5 and @ash_d_sanders 🍾🎉🥳 5/5

In another patient with paired pre- and post-treatment samples, two distinct subclones persisted post venetoclax-based treatment. Both had subclone-specific mechanisms to further resistance: a shift toward MEP-like cells and NF1 loss. Go and read more about the other cases! 📜4/5

Extremely proud to see my PhD project exploring intra-tumor heterogeneity in complex karyotype AML finally out in @NatureGenet ! 🎉👩🏻‍🔬 They say that 10,000 hours make you an expert, so I guess after more than five years of work I’m half-way there 😅 ⬇️1/5 nature.com/articles/s4158…

There's a lot of excitement about foundation models and their ability to learn biology 🧬💻 But current tools for perturbation prediction perform worse than simple linear models! We need more careful benchmarking to make progress. biorxiv.org/content/10.110…

Interested in the "Arms-Race" against therapy resistance in Acute Myeloid Leukemia? Read our perspective just published in molecular oncology. febs.onlinelibrary.wiley.com/doi/10.1002/18… @hi_stem_lab @amleppa @SimonRenders

Just uploaded a new version of the LEMUR manuscript biorxiv.org/content/10.110… 🎉🥳 LEMUR disentangles observed and latent factors of multi-condition single-cell data and finds groups of cells with consistent differential expression for each gene. Details on the changes ⬇️

Excited to announce: International Heidelberg Symposium on Stem Cells and Cancer on Sep 10-12, 2023 @DKFZ. Worldwide opinion leaders present latest data on cancer stem cells, tumor heterogeneity, therapy resistance & more! Registration for FREE @ stem-cells-cancer.de. #SCC2023

Incredibly proud to see our benchmark of single-cell preprocessing methods finally published 🥳🥳🎉 We show that despite its theoretical limitations, no other transformation consistently outperforms log(y/s+1). All details at nature.com/articles/s4159… and github.com/const-ae/trans…

Thrilled to share some of the exciting results from my PhD from an amazing collaboration with @AlexWaclawiczek @SimonRenders at Trumpp Lab @hi_stem_lab 🎉🎉