Antoneta Granic

Delighted to share our latest review about the Hallmarks of Ageing potentially relevant for skeletal muscle ageing & sarcopenia in women & men doi.org/10.1042/CS2023… #ClinSci @PPPublishing by @NewcastleAGE & collaborators. @NIHRNewcBRC @UniofNewcastle 🥳

🧬 If polyphenols slow aging, they probably aren't doing it by acting purely as antioxidants. They interact with multiple core aging pathways at once: mitochondrial function, inflammation, autophagy, proteostasis, epigenetic regulation, and cellular senescence. That matters because aging is a systems problem, not a single-pathway one. Seen consistently in long-lived populations eating diverse plant-rich diets. 📖 Source: Davinelli et al., Ageing Research Reviews

Delighted to share our latest review about how human Vastus Lateralis muscle ages, a collaborative work between @NewcastleAGE @NIHRNewcBRC @UniofNewcastle, @NorthumbriaUni and @UniversityLeeds. doi.org/10.1016/j.arr.… @ElsevierConnect #AgeingResearchReviews

Excited to share the culmination of all the food weighing, resistance exercise training and muscle prepping as part of my PhD is now available to read online and in a great home in The American Journal of Clinical Nutrition! ajcn.nutrition.org/article/S0002-…

Our new @tilda_tcd @geronsociety paper demonstrates the potential health benefits of regular dog walking in later life: - Better mobility - 40% less Falls - 20% less Fear of Falling pubmed.ncbi.nlm.nih.gov/39798070/ @RoseAnnekenny1 @amandahlavan @TCDGerontology

A new microscopy method integrating mitochondrial function and morphology assessment reveals spatial patterns in oxidative phosphorylation within the muscle fibers of patients with mtDNA deletions. nature.com/articles/s4200… @JuFaitg @AmyV91 @mitomusclelab @EMRSncl @UniofNewcastle

Atlas of the plasma proteome in health and disease in 53,026 adults cell.com/cell/fulltext/…

The various risk factors, present throughout a person's lifetime, which increase a person’s chances of developing dementia. If you are more deprived, you are less likely to have access to quality services and more likely to get a diagnosis of unspecified dementia #BGSconf

Out today in Nature: "The Human Cell Atlas"! In my commentary, I compare the cell atlas to early naturalists exploring South America. Researchers mining this cell atlas can now make big discoveries, just as the next naturalists then discovered evolution. nature.com/articles/d4158…

Three clinical researchers in Newcastle have been awarded highly sought-after Starter Grants for Clinical Lecturers from the Academy of Medical Sciences, with support from NHIP Academy. Read more here: newcastlehealthinnovation.org/news/nhip-acad…

Not all p16-senescent cells are born equal. doi.org/10.1016/j.cell… In this elegant study targeted ablation of p16-positive macrophages or EC cells has the opposite effect on liver injury outcome. The elimination of p16+ Mф diminished fibrosis and the elimination of p16+ ECs augmented it. This study together with other works on the heterogeneity of senescent cells raises the question if non-selective senolysis is an appropriate approach to cure aging. (@LidskyPeter ) Senescent cells slowly turn out not to be pure evil, but like, everything else, partially adaptive and partially maladaptive context-specific respons to a stress. It also explains why senolytics fail to prolong mice's lifespan more than 15-20%.

Excited to share our latest paper published in @NatureComms in which we characterize a novel Foxo-Dependent gene, MYTHO, as a regulator of muscle mass, autophagy and integrity. This was a fantastic collaboration with @LabSandri, S Hussain and more. nature.com/articles/s4146…

GLP-1 receptor agonists are revolutionizing obesity treatment but can cause significant muscle loss. ​ Balancing weight loss with muscle preservation is crucial for overall health. ​ Future research and strategic approaches, including nutrition and exercise, are essential. #Sarcopenia #MuscleHealth #GLP1 #WeightLoss sciencedirect.com/science/articl…

📣 Our most popular BJSM post ever? 🤯 NEW #Infographic❗️This is not one to miss 👀 Muscle-strengthening exercise for older adults: a critical strategy for maintaining health and independence 💪 ✅ Full article ➡️ bit.ly/4eMFLA2

Our latest paper on aging is finally out in @ExpPhysiol. This is a real IHC tour de force on muscle morphology, satellite cells, capillaries and innervation status so if you are into that, check it out! @SebastianEdman @MobergPhD @andyphilp_lab @WiApro physoc.onlinelibrary.wiley.com/doi/full/10.11…

Free scientific illustrations for biologists! 😍 @NIH has released a library of 500+ free scientific illustrations to create figures, presentations, and illustrations! all freely available in the public domain. Retweet and spread the message! bioart.niaid.nih.gov

Each year, @NewcastleAGE supervise student projects and host summer placement students who are interested in ageing research. The research is closely linked to the Ageing, Sarcopenia and Multimorbidity Theme within the @NIHRNewcBRC. Read about their experience 👇

Senescence in the ageing skin: a new focus on mTORC1 and the lysosome febs.onlinelibrary.wiley.com/doi/10.1111/fe…